Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease: a combined [11C]DASB and [18F]altanserin-PET study
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Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease : a combined [11C]DASB and [18F]altanserin-PET study. / Marner, Lisbeth; Frokjaer, Vibe G; Kalbitzer, Jan; Lehel, Szabolcs; Madsen, Karine; Baaré, William F C; Knudsen, Gitte M; Hasselbalch, Steen G.
In: Neurobiology of Aging, Vol. 33, No. 3, 2012, p. 479-87.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease
T2 - a combined [11C]DASB and [18F]altanserin-PET study
AU - Marner, Lisbeth
AU - Frokjaer, Vibe G
AU - Kalbitzer, Jan
AU - Lehel, Szabolcs
AU - Madsen, Karine
AU - Baaré, William F C
AU - Knudsen, Gitte M
AU - Hasselbalch, Steen G
N1 - Copyright © 2010 Elsevier Inc. All rights reserved.
PY - 2012
Y1 - 2012
N2 - In patients with Alzheimer's disease (AD), postmortem and imaging studies have revealed early and prominent reductions in cerebral serotonin 2A (5-HT(2A)) receptors. To establish if this was due to a selective disease process of the serotonin system, we investigated the cerebral 5-HT(2A) receptor and the serotonin transporter binding, the latter as a measure of serotonergic projections and neurons. Twelve patients with AD (average Mini Mental State Examination [MMSE]: 24) and 11 healthy age-matched subjects underwent positron emission tomography (PET) scanning with [(18)F]altanserin and [(11)C]N,N-Dimethyl-2-(2-amino-4-cyanopheylthio)benzylamine ([(11)C]DASB). Overall [(18)F]altanserin binding was markedly reduced in AD by 28%-39% (p = 0.02), whereas the reductions in [(11)C]DASB binding were less prominent and mostly insignificant, except for a marked reduction of 33% in mesial temporal cortex (p = .0005). No change in [(11)C]DASB binding was found in the midbrain. We conclude that the prominent reduction in neocortical 5-HT(2A) receptor binding in early AD is not caused by a primary loss of serotonergic neurons or their projections.
AB - In patients with Alzheimer's disease (AD), postmortem and imaging studies have revealed early and prominent reductions in cerebral serotonin 2A (5-HT(2A)) receptors. To establish if this was due to a selective disease process of the serotonin system, we investigated the cerebral 5-HT(2A) receptor and the serotonin transporter binding, the latter as a measure of serotonergic projections and neurons. Twelve patients with AD (average Mini Mental State Examination [MMSE]: 24) and 11 healthy age-matched subjects underwent positron emission tomography (PET) scanning with [(18)F]altanserin and [(11)C]N,N-Dimethyl-2-(2-amino-4-cyanopheylthio)benzylamine ([(11)C]DASB). Overall [(18)F]altanserin binding was markedly reduced in AD by 28%-39% (p = 0.02), whereas the reductions in [(11)C]DASB binding were less prominent and mostly insignificant, except for a marked reduction of 33% in mesial temporal cortex (p = .0005). No change in [(11)C]DASB binding was found in the midbrain. We conclude that the prominent reduction in neocortical 5-HT(2A) receptor binding in early AD is not caused by a primary loss of serotonergic neurons or their projections.
U2 - 10.1016/j.neurobiolaging.2010.03.023
DO - 10.1016/j.neurobiolaging.2010.03.023
M3 - Journal article
C2 - 20510480
VL - 33
SP - 479
EP - 487
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 3
ER -
ID: 35304438