Intraoperative platelet and plasma improves survival in patients operated for a rAAA: a follow-up evaluation
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Intraoperative platelet and plasma improves survival in patients operated for a rAAA: a follow-up evaluation. / Johansson, Per Ingemar; Swiatek, F.; Jorgensen, L.; Jensen, Leif Pandora; Secher, N.H.
In: European Journal of Vascular and Endovascular Surgery, Vol. 36, No. 4, 2008, p. 397-400.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Intraoperative platelet and plasma improves survival in patients operated for a rAAA: a follow-up evaluation
AU - Johansson, Per Ingemar
AU - Swiatek, F.
AU - Jorgensen, L.
AU - Jensen, Leif Pandora
AU - Secher, N.H.
PY - 2008
Y1 - 2008
N2 - OBJECTIVES: Continued haemorrhage remains a significant contributor to mortality in massively transfused patients. We found that early administration of platelets and plasma reduced mortality from 54% to 36% in rAAA patients. The aim of the present evaluation was to evaluate whether reduced mortality in rAAA patients related to a pro-active transfusion therapy is maintained. DESIGN: Single-centre observational study. METHODS: Mortality of patients operated for rAAA 2006-07 was compared to that of patients operated 2004-05 (intervention group; n=50) and 2002-04 (control group, n=82). RESULTS: 64 consecutive patients with rAAA received, similar to the intervention group, more platelets (5 and 4 vs. 0 units, P<0.05) and plasma (12 and 11 vs. 7 units, P<0.05) intraoperatively and had a higher platelet count (158 and 155 vs. 69 x 10(9)/L, P<0.0001) upon arrival at the intensive care unit and the 30-day mortality remained reduced (24% and 36% vs. 56%, P<0.01 and P=0.02, respectively) as compared to the control patients. CONCLUSIONS: Early administration of platelets and plasma, together with red blood cells maintained reduced mortality in patients operated for rAAAin a 18 month period Udgivelsesdato: 2008/10
AB - OBJECTIVES: Continued haemorrhage remains a significant contributor to mortality in massively transfused patients. We found that early administration of platelets and plasma reduced mortality from 54% to 36% in rAAA patients. The aim of the present evaluation was to evaluate whether reduced mortality in rAAA patients related to a pro-active transfusion therapy is maintained. DESIGN: Single-centre observational study. METHODS: Mortality of patients operated for rAAA 2006-07 was compared to that of patients operated 2004-05 (intervention group; n=50) and 2002-04 (control group, n=82). RESULTS: 64 consecutive patients with rAAA received, similar to the intervention group, more platelets (5 and 4 vs. 0 units, P<0.05) and plasma (12 and 11 vs. 7 units, P<0.05) intraoperatively and had a higher platelet count (158 and 155 vs. 69 x 10(9)/L, P<0.0001) upon arrival at the intensive care unit and the 30-day mortality remained reduced (24% and 36% vs. 56%, P<0.01 and P=0.02, respectively) as compared to the control patients. CONCLUSIONS: Early administration of platelets and plasma, together with red blood cells maintained reduced mortality in patients operated for rAAAin a 18 month period Udgivelsesdato: 2008/10
M3 - Journal article
VL - 36
SP - 397
EP - 400
JO - European Journal of Vascular and Endovascular Surgery
JF - European Journal of Vascular and Endovascular Surgery
SN - 1078-5884
IS - 4
ER -
ID: 10906472