Infliximab dependency is related to decreased surgical rates in adult Crohn's disease patients
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Infliximab dependency is related to decreased surgical rates in adult Crohn's disease patients. / Pedersen, N.; Duricova, D.; Lenicek, M.; Elkjaer, M.; Bortlik, M.; Andersen, P.S.; Vitek, L.; Davidsen, B.; Wewer, V.; Lukas, Manuel Sebastian; Munkholm, P.
In: European Journal of Gastroenterology and Hepatology, Vol. 22, No. 10, 2010, p. 1196-1203.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Infliximab dependency is related to decreased surgical rates in adult Crohn's disease patients
AU - Pedersen, N.
AU - Duricova, D.
AU - Lenicek, M.
AU - Elkjaer, M.
AU - Bortlik, M.
AU - Andersen, P.S.
AU - Vitek, L.
AU - Davidsen, B.
AU - Wewer, V.
AU - Lukas, Manuel Sebastian
AU - Munkholm, P.
PY - 2010
Y1 - 2010
N2 - Background Infliximab dependency in children with Crohn's disease (CD) has recently been described and found to be associated with a decreased surgery rate. Aim To assess infliximab dependency of adult CD patients, evaluate the impact on surgery, and search for possible clinical and genetic predictors. Methods Two hundred and forty-five CD patients treated with infliximab were included from Danish and Czech Crohn Colitis Database (1999-2006). Infliximab response was assessed as immediate outcome, 1 month after infliximab start: complete, partial, and no response. Three months outcome, after last intended infusion: prolonged response (maintenance of complete/partial response), infliximab dependency (relapse requiring repeated infusions to regain complete/partial response or need of infliximab > 12 months to sustain response). Results Forty-seven percent obtained prolonged response, 29% were infliximab dependent and 24% nonresponders. The cumulative probability of surgery 40 months after infliximab start was 20% in prolonged responders, 23% in infliximab-dependent patients and 76% in nonresponders (P <0.001). The cumulative probability of surgery at 40 months in patients on maintenance versus on demand regime was 33 and 31%, respectively (P = 0.63). No relevant clinical or genetic predictors were identified. Conclusion The infliximab dependency response seems to be equivalent to the prolonged response in adult CD patients when comparing surgery rates. Eur J Gastroenterol Hepatol 22: 1196-1203 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins
AB - Background Infliximab dependency in children with Crohn's disease (CD) has recently been described and found to be associated with a decreased surgery rate. Aim To assess infliximab dependency of adult CD patients, evaluate the impact on surgery, and search for possible clinical and genetic predictors. Methods Two hundred and forty-five CD patients treated with infliximab were included from Danish and Czech Crohn Colitis Database (1999-2006). Infliximab response was assessed as immediate outcome, 1 month after infliximab start: complete, partial, and no response. Three months outcome, after last intended infusion: prolonged response (maintenance of complete/partial response), infliximab dependency (relapse requiring repeated infusions to regain complete/partial response or need of infliximab > 12 months to sustain response). Results Forty-seven percent obtained prolonged response, 29% were infliximab dependent and 24% nonresponders. The cumulative probability of surgery 40 months after infliximab start was 20% in prolonged responders, 23% in infliximab-dependent patients and 76% in nonresponders (P <0.001). The cumulative probability of surgery at 40 months in patients on maintenance versus on demand regime was 33 and 31%, respectively (P = 0.63). No relevant clinical or genetic predictors were identified. Conclusion The infliximab dependency response seems to be equivalent to the prolonged response in adult CD patients when comparing surgery rates. Eur J Gastroenterol Hepatol 22: 1196-1203 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins
U2 - http://dx.doi.org/10.1097/MEG.0b013e32833dde2e
DO - http://dx.doi.org/10.1097/MEG.0b013e32833dde2e
M3 - Journal article
VL - 22
SP - 1196
EP - 1203
JO - European Journal of Gastroenterology and Hepatology, Supplement
JF - European Journal of Gastroenterology and Hepatology, Supplement
SN - 0954-691X
IS - 10
ER -
ID: 34047320