Indexing Glomerular Filtration Rate to Body Surface Area: Clinical Consequences
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Indexing Glomerular Filtration Rate to Body Surface Area : Clinical Consequences. / Redal-Baigorri, Belén; Rasmussen, Knud; Heaf, James Goya.
In: Journal of Clinical Laboratory Analysis, Vol. 28, No. 2, 03.2014, p. 83-90.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Indexing Glomerular Filtration Rate to Body Surface Area
T2 - Clinical Consequences
AU - Redal-Baigorri, Belén
AU - Rasmussen, Knud
AU - Heaf, James Goya
N1 - © 2013 Wiley Periodicals, Inc.
PY - 2014/3
Y1 - 2014/3
N2 - BACKGROUND: Kidney function is mostly expressed in terms of glomerular filtration rate (GFR). A common feature is the expression as ml/min per 1.73 m(2) , which represents the adjustment of the individual kidney function to a standard body surface area (BSA) to allow comparison between individuals. We investigated the impact of indexing GFR to BSA in cancer patients, as this BSA indexation might affect the reported individual kidney function.METHODS: Cross-sectional study of 895 adults who had their kidney function measured with (51) chrome ethylene diamine tetraacetic acid. Mean values of BSA-indexed GFR vs. mean absolute GFR were analyzed with a t-test for paired data. Bland-Altman plot was used to analyze agreement between the indexed and absolute GFR values.RESULTS AND CONCLUSION: BSA-GFR in patients with a BSA <1.60 m(2) overestimated GFR with a bias of 10.08 ml/min (11.46%) and underestimated GFR in those with a BSA >2 m(2) with a bias up to -20.76 ml/min (-23.59%). BSA is not a good normalization index (NI) in patients with extreme body sizes. Therefore, until a better NI is found, we recommend clinicians to use the absolute GFR to calculate individual drug chemotherapy dosage as well as express individual kidney function.
AB - BACKGROUND: Kidney function is mostly expressed in terms of glomerular filtration rate (GFR). A common feature is the expression as ml/min per 1.73 m(2) , which represents the adjustment of the individual kidney function to a standard body surface area (BSA) to allow comparison between individuals. We investigated the impact of indexing GFR to BSA in cancer patients, as this BSA indexation might affect the reported individual kidney function.METHODS: Cross-sectional study of 895 adults who had their kidney function measured with (51) chrome ethylene diamine tetraacetic acid. Mean values of BSA-indexed GFR vs. mean absolute GFR were analyzed with a t-test for paired data. Bland-Altman plot was used to analyze agreement between the indexed and absolute GFR values.RESULTS AND CONCLUSION: BSA-GFR in patients with a BSA <1.60 m(2) overestimated GFR with a bias of 10.08 ml/min (11.46%) and underestimated GFR in those with a BSA >2 m(2) with a bias up to -20.76 ml/min (-23.59%). BSA is not a good normalization index (NI) in patients with extreme body sizes. Therefore, until a better NI is found, we recommend clinicians to use the absolute GFR to calculate individual drug chemotherapy dosage as well as express individual kidney function.
KW - Adult
KW - Body Surface Area
KW - Female
KW - Glomerular Filtration Rate
KW - Humans
KW - Male
KW - Middle Aged
KW - Reference Standards
U2 - 10.1002/jcla.21648
DO - 10.1002/jcla.21648
M3 - Journal article
C2 - 24375613
VL - 28
SP - 83
EP - 90
JO - Journal of Clinical Laboratory Analysis
JF - Journal of Clinical Laboratory Analysis
SN - 0887-8013
IS - 2
ER -
ID: 135499363