Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele
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Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele. / Faerch, Kristine; Pilgaard, Kasper; Knop, Filip K; Hansen, Torben; Pedersen, Oluf; Jørgensen, Torben; Holst, Jens J.
In: Diabetes, Obesity and Metabolism Online, Vol. 15, No. 1, 2012, p. 91-95.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele
AU - Faerch, Kristine
AU - Pilgaard, Kasper
AU - Knop, Filip K
AU - Hansen, Torben
AU - Pedersen, Oluf
AU - Jørgensen, Torben
AU - Holst, Jens J
N1 - © 2012 Blackwell Publishing Ltd.
PY - 2012
Y1 - 2012
N2 - We characterised 62 non-diabetic, middle-aged, Caucasians with and without the T risk allele of rs7903146 in TCF7L2 with regard to secretion of insulin, glucagon, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) as well as insulin sensitivity and endogenous glucose production. All participants had a 3-hour oral glucose tolerance test (OGTT), an intravenous glucose tolerance test, and a euglycaemic, hyperinsulinaemic clamp. After adjustment for age and sex, risk T allele carriers had higher HbA(1c) levels (P=0.030), reduced first-phase insulin response (P=0.048), higher peripheral insulin sensitivity (P=0.050) and lower fasting GIP concentrations (P=0.003) than CC allele carriers. The latter was also reflected by lower total GIP secretion during the OGTT (P=0.018). We found no significant differences in endogenous glucose production, hepatic insulin sensitivity or fasting concentrations of glucose, insulin, glucagon, and GLP-1 between the groups. The findings suggest that the effect of TCF7L2 on diabetes risk may include reduced secretion of GIP.
AB - We characterised 62 non-diabetic, middle-aged, Caucasians with and without the T risk allele of rs7903146 in TCF7L2 with regard to secretion of insulin, glucagon, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) as well as insulin sensitivity and endogenous glucose production. All participants had a 3-hour oral glucose tolerance test (OGTT), an intravenous glucose tolerance test, and a euglycaemic, hyperinsulinaemic clamp. After adjustment for age and sex, risk T allele carriers had higher HbA(1c) levels (P=0.030), reduced first-phase insulin response (P=0.048), higher peripheral insulin sensitivity (P=0.050) and lower fasting GIP concentrations (P=0.003) than CC allele carriers. The latter was also reflected by lower total GIP secretion during the OGTT (P=0.018). We found no significant differences in endogenous glucose production, hepatic insulin sensitivity or fasting concentrations of glucose, insulin, glucagon, and GLP-1 between the groups. The findings suggest that the effect of TCF7L2 on diabetes risk may include reduced secretion of GIP.
U2 - 10.1111/j.1463-1326.2012.01675.x
DO - 10.1111/j.1463-1326.2012.01675.x
M3 - Journal article
C2 - 22862926
VL - 15
SP - 91
EP - 95
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
SN - 1462-8902
IS - 1
ER -
ID: 40327055