Immunological effects of methylprednisolone pulse treatment in progressive multiple sclerosis
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Immunological effects of methylprednisolone pulse treatment in progressive multiple sclerosis. / Ratzer, R; Romme Christensen, J; Romme Nielsen, B; Sørensen, P S; Börnsen, L; Sellebjerg, F.
In: Journal of Neuroimmunology, Vol. 276, No. 1-2, 15.11.2014, p. 195-201.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Immunological effects of methylprednisolone pulse treatment in progressive multiple sclerosis
AU - Ratzer, R
AU - Romme Christensen, J
AU - Romme Nielsen, B
AU - Sørensen, P S
AU - Börnsen, L
AU - Sellebjerg, F
N1 - Copyright © 2014 Elsevier B.V. All rights reserved.
PY - 2014/11/15
Y1 - 2014/11/15
N2 - OBJECTIVE: To investigate the effect of monthly oral methylprednisolone pulse treatment in progressive MS.METHODS: 30 progressive MS patients were treated with oral methylprednisolone every month. Peripheral blood mononuclear cells were analyzed by flow cytometry.RESULTS: Out of 102 leukocyte phenotypes investigated, 25 changed at nominal significance from baseline to week 12 (p<0.05). After correction for multiple comparisons, we found 5 subpopulations that changed compared to baseline. No pattern were suggesting modulation of Th17 or TFH cells.CONCLUSION: Methylprednisolone pulse treatment has some effects on circulating immune cells but does not modulate markers of Th17 and TFH cell activity in progressive MS.
AB - OBJECTIVE: To investigate the effect of monthly oral methylprednisolone pulse treatment in progressive MS.METHODS: 30 progressive MS patients were treated with oral methylprednisolone every month. Peripheral blood mononuclear cells were analyzed by flow cytometry.RESULTS: Out of 102 leukocyte phenotypes investigated, 25 changed at nominal significance from baseline to week 12 (p<0.05). After correction for multiple comparisons, we found 5 subpopulations that changed compared to baseline. No pattern were suggesting modulation of Th17 or TFH cells.CONCLUSION: Methylprednisolone pulse treatment has some effects on circulating immune cells but does not modulate markers of Th17 and TFH cell activity in progressive MS.
KW - Adult
KW - Anti-Inflammatory Agents
KW - Female
KW - Flow Cytometry
KW - Humans
KW - Leukocytes, Mononuclear
KW - Male
KW - Methylprednisolone
KW - Middle Aged
KW - Multiple Sclerosis
KW - Severity of Illness Index
U2 - 10.1016/j.jneuroim.2014.08.623
DO - 10.1016/j.jneuroim.2014.08.623
M3 - Journal article
C2 - 25218212
VL - 276
SP - 195
EP - 201
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -
ID: 137740406