HIV infection and arterial inflammation assessed by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET): A prospective cross-sectional study

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Standard

HIV infection and arterial inflammation assessed by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) : A prospective cross-sectional study. / Knudsen, Andreas; Hag, Anne Mette Fisker; Loft, Annika; von Benzon, Eric; Keller, Sune H; Møller, Holger Jon; Lebech, Anne-Mette; Ripa, Rasmus Sejersten; Kjær, Andreas.

In: Journal of Nuclear Cardiology, Vol. 22, No. 2, 04.2015, p. 372-80.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Knudsen, A, Hag, AMF, Loft, A, von Benzon, E, Keller, SH, Møller, HJ, Lebech, A-M, Ripa, RS & Kjær, A 2015, 'HIV infection and arterial inflammation assessed by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET): A prospective cross-sectional study', Journal of Nuclear Cardiology, vol. 22, no. 2, pp. 372-80. https://doi.org/10.1007/s12350-014-0032-0

APA

Knudsen, A., Hag, A. M. F., Loft, A., von Benzon, E., Keller, S. H., Møller, H. J., Lebech, A-M., Ripa, R. S., & Kjær, A. (2015). HIV infection and arterial inflammation assessed by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET): A prospective cross-sectional study. Journal of Nuclear Cardiology, 22(2), 372-80. https://doi.org/10.1007/s12350-014-0032-0

Vancouver

Knudsen A, Hag AMF, Loft A, von Benzon E, Keller SH, Møller HJ et al. HIV infection and arterial inflammation assessed by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET): A prospective cross-sectional study. Journal of Nuclear Cardiology. 2015 Apr;22(2):372-80. https://doi.org/10.1007/s12350-014-0032-0

Author

Knudsen, Andreas ; Hag, Anne Mette Fisker ; Loft, Annika ; von Benzon, Eric ; Keller, Sune H ; Møller, Holger Jon ; Lebech, Anne-Mette ; Ripa, Rasmus Sejersten ; Kjær, Andreas. / HIV infection and arterial inflammation assessed by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) : A prospective cross-sectional study. In: Journal of Nuclear Cardiology. 2015 ; Vol. 22, No. 2. pp. 372-80.

Bibtex

@article{3aa357692d644820b5a9b64818d3c56f,
title = "HIV infection and arterial inflammation assessed by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET): A prospective cross-sectional study",
abstract = "BACKGROUND: HIV-infected patients are at increased risk of myocardial infarction and arterial inflammation has been suggested as a pathophysiological explanation. We compared the uptake of (18)F-fluorodeoxyglucose (FDG) by PET in four arterial regions, and factors associated with FDG uptake in well-treated HIV-infected patients without cardiovascular disease (CVD) and healthy controls.METHODS AND RESULTS: We prospectively scanned 26 HIV-infected patients on stable antiretroviral therapy and 25 healthy volunteers with FDG PET/CT, measuring standardized uptake values (SUV) in the carotid arteries, the ascending, descending, and abdominal aorta. We performed correlation analyses between FDG uptake and intima-media thickness (IMT), and soluble biomarkers of inflammation. We found no difference in arterial FDG uptake between the HIV-infected patients and healthy controls quantified either as mean SUVmax or target-to background ratio in the carotid region, the ascending aorta, the descending aorta, or the abdominal aorta. Correlations between SUV, IMT, and soluble biomarkers were scarce in both groups.CONCLUSION: In a group of optimally treated HIV-infected patients with full viral suppression, low Framingham risk score and no known CVD, we found no evidence of increased arterial inflammation as assessed by FDG PET/CT compared to healthy volunteers.",
author = "Andreas Knudsen and Hag, {Anne Mette Fisker} and Annika Loft and {von Benzon}, Eric and Keller, {Sune H} and M{\o}ller, {Holger Jon} and Anne-Mette Lebech and Ripa, {Rasmus Sejersten} and Andreas Kj{\ae}r",
year = "2015",
month = apr,
doi = "10.1007/s12350-014-0032-0",
language = "English",
volume = "22",
pages = "372--80",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - HIV infection and arterial inflammation assessed by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)

T2 - A prospective cross-sectional study

AU - Knudsen, Andreas

AU - Hag, Anne Mette Fisker

AU - Loft, Annika

AU - von Benzon, Eric

AU - Keller, Sune H

AU - Møller, Holger Jon

AU - Lebech, Anne-Mette

AU - Ripa, Rasmus Sejersten

AU - Kjær, Andreas

PY - 2015/4

Y1 - 2015/4

N2 - BACKGROUND: HIV-infected patients are at increased risk of myocardial infarction and arterial inflammation has been suggested as a pathophysiological explanation. We compared the uptake of (18)F-fluorodeoxyglucose (FDG) by PET in four arterial regions, and factors associated with FDG uptake in well-treated HIV-infected patients without cardiovascular disease (CVD) and healthy controls.METHODS AND RESULTS: We prospectively scanned 26 HIV-infected patients on stable antiretroviral therapy and 25 healthy volunteers with FDG PET/CT, measuring standardized uptake values (SUV) in the carotid arteries, the ascending, descending, and abdominal aorta. We performed correlation analyses between FDG uptake and intima-media thickness (IMT), and soluble biomarkers of inflammation. We found no difference in arterial FDG uptake between the HIV-infected patients and healthy controls quantified either as mean SUVmax or target-to background ratio in the carotid region, the ascending aorta, the descending aorta, or the abdominal aorta. Correlations between SUV, IMT, and soluble biomarkers were scarce in both groups.CONCLUSION: In a group of optimally treated HIV-infected patients with full viral suppression, low Framingham risk score and no known CVD, we found no evidence of increased arterial inflammation as assessed by FDG PET/CT compared to healthy volunteers.

AB - BACKGROUND: HIV-infected patients are at increased risk of myocardial infarction and arterial inflammation has been suggested as a pathophysiological explanation. We compared the uptake of (18)F-fluorodeoxyglucose (FDG) by PET in four arterial regions, and factors associated with FDG uptake in well-treated HIV-infected patients without cardiovascular disease (CVD) and healthy controls.METHODS AND RESULTS: We prospectively scanned 26 HIV-infected patients on stable antiretroviral therapy and 25 healthy volunteers with FDG PET/CT, measuring standardized uptake values (SUV) in the carotid arteries, the ascending, descending, and abdominal aorta. We performed correlation analyses between FDG uptake and intima-media thickness (IMT), and soluble biomarkers of inflammation. We found no difference in arterial FDG uptake between the HIV-infected patients and healthy controls quantified either as mean SUVmax or target-to background ratio in the carotid region, the ascending aorta, the descending aorta, or the abdominal aorta. Correlations between SUV, IMT, and soluble biomarkers were scarce in both groups.CONCLUSION: In a group of optimally treated HIV-infected patients with full viral suppression, low Framingham risk score and no known CVD, we found no evidence of increased arterial inflammation as assessed by FDG PET/CT compared to healthy volunteers.

U2 - 10.1007/s12350-014-0032-0

DO - 10.1007/s12350-014-0032-0

M3 - Journal article

C2 - 25467249

VL - 22

SP - 372

EP - 380

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

IS - 2

ER -

ID: 131997100