Histone demethylases in development and disease
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Histone demethylases in development and disease. / Pedersen, Marianne Terndrup; Helin, Kristian.
In: Trends in Cell Biology, Vol. 20, No. 11, 01.11.2010, p. 662-71.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Histone demethylases in development and disease
AU - Pedersen, Marianne Terndrup
AU - Helin, Kristian
N1 - Copyright © 2010 Elsevier Ltd. All rights reserved.
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Histone modifications serve as regulatory marks that are instrumental for the control of transcription and chromatin architecture. Strict regulation of gene expression patterns is crucial during development and differentiation, where diverse cell types evolve from common predecessors. Since the first histone lysine demethylase was discovered in 2004, a number of demethylases have been identified and implicated in the control of gene expression programmes and cell fate decisions. Histone demethylases are now emerging as important players in developmental processes and have been linked to human diseases such as neurological disorders and cancer.
AB - Histone modifications serve as regulatory marks that are instrumental for the control of transcription and chromatin architecture. Strict regulation of gene expression patterns is crucial during development and differentiation, where diverse cell types evolve from common predecessors. Since the first histone lysine demethylase was discovered in 2004, a number of demethylases have been identified and implicated in the control of gene expression programmes and cell fate decisions. Histone demethylases are now emerging as important players in developmental processes and have been linked to human diseases such as neurological disorders and cancer.
KW - Animals
KW - Gene Expression Regulation
KW - Histone Demethylases
KW - Humans
KW - Mammals
KW - Neoplasms
KW - Nervous System Diseases
U2 - 10.1016/j.tcb.2010.08.011
DO - 10.1016/j.tcb.2010.08.011
M3 - Journal article
C2 - 20863703
VL - 20
SP - 662
EP - 671
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 11
ER -
ID: 33825214