High-Risk and Low-Risk Human Papillomavirus and the Absolute Risk of Cervical Intraepithelial Neoplasia or Cancer

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High-Risk and Low-Risk Human Papillomavirus and the Absolute Risk of Cervical Intraepithelial Neoplasia or Cancer. / Thomsen, Louise T; Frederiksen, Kirsten; Munk, Christian; Junge, Jette; Castle, Philip E; Iftner, Thomas; Kjaer, Susanne K.

In: Obstetrics and Gynecology, Vol. 123, No. 1, 01.2014, p. 57-64.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Thomsen, LT, Frederiksen, K, Munk, C, Junge, J, Castle, PE, Iftner, T & Kjaer, SK 2014, 'High-Risk and Low-Risk Human Papillomavirus and the Absolute Risk of Cervical Intraepithelial Neoplasia or Cancer', Obstetrics and Gynecology, vol. 123, no. 1, pp. 57-64. https://doi.org/10.1097/AOG.0000000000000056

APA

Thomsen, L. T., Frederiksen, K., Munk, C., Junge, J., Castle, P. E., Iftner, T., & Kjaer, S. K. (2014). High-Risk and Low-Risk Human Papillomavirus and the Absolute Risk of Cervical Intraepithelial Neoplasia or Cancer. Obstetrics and Gynecology, 123(1), 57-64. https://doi.org/10.1097/AOG.0000000000000056

Vancouver

Thomsen LT, Frederiksen K, Munk C, Junge J, Castle PE, Iftner T et al. High-Risk and Low-Risk Human Papillomavirus and the Absolute Risk of Cervical Intraepithelial Neoplasia or Cancer. Obstetrics and Gynecology. 2014 Jan;123(1):57-64. https://doi.org/10.1097/AOG.0000000000000056

Author

Thomsen, Louise T ; Frederiksen, Kirsten ; Munk, Christian ; Junge, Jette ; Castle, Philip E ; Iftner, Thomas ; Kjaer, Susanne K. / High-Risk and Low-Risk Human Papillomavirus and the Absolute Risk of Cervical Intraepithelial Neoplasia or Cancer. In: Obstetrics and Gynecology. 2014 ; Vol. 123, No. 1. pp. 57-64.

Bibtex

@article{be257e2660c441bb8cd9f458c8f89641,
title = "High-Risk and Low-Risk Human Papillomavirus and the Absolute Risk of Cervical Intraepithelial Neoplasia or Cancer",
abstract = "OBJECTIVE: To determine the absolute risk of cervical intraepithelial neoplasia (CIN) grade 3 or cervical cancer (CIN 3 or worse) after detection of low-risk human papillomavirus (HPV) and after a negative high-risk HPV test.METHODS: In this prospective cohort study, consecutive liquid-based cervical cytology samples were collected from women screened for cervical cancer in Copenhagen, Denmark, during 2002-2005. Samples were tested with a clinical test for 13 high-risk and five low-risk HPV types. The cohort (N=35,539; aged 14-90 years) was monitored in a nationwide pathology register for up to 10.5 years for development of CIN 3 or worse.RESULTS: The 8-year absolute risk of CIN 3 or worse was 1.1% (95% confidence interval [CI] 1.0-1.3%) for HPV-negative women; 1.7% (0.8-2.6%) for low-risk HPV-positive women without concurrent high-risk HPV; 17.4% (16.4-18.5%) for high-risk HPV-positive women without concurrent low-risk HPV; and 15.9% (13.5-18.3%) for women with concurrent high-risk and low-risk HPV. The 8-year absolute risk of CIN 3 or worse after a negative high-risk HPV test (irrespective of low-risk HPV status) was lower than after a normal cytology result among women aged younger than 30 years (3.5% [95% CI, 2.9-4.0%] compared with 6.9% [6.2-7.5%], P<.001) and women aged 30 years or older (0.7% [95% CI, 0.6-0.9%] compared with 1.8% [95% CI, 1.6-2.0%], P<.001).CONCLUSION: A negative high-risk HPV test provides greater long-term reassurance against CIN 3 or worse than normal cytology. Detection of low-risk HPV does not predict CIN 3 or worse. Cervical cancer screening should not include testing for low-risk HPV types.LEVEL OF EVIDENCE: II.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Cervical Intraepithelial Neoplasia, Cervix Uteri, Denmark, Female, Humans, Middle Aged, Papillomaviridae, Prospective Studies, Risk Assessment, Uterine Cervical Neoplasms, Young Adult",
author = "Thomsen, {Louise T} and Kirsten Frederiksen and Christian Munk and Jette Junge and Castle, {Philip E} and Thomas Iftner and Kjaer, {Susanne K}",
year = "2014",
month = jan,
doi = "10.1097/AOG.0000000000000056",
language = "English",
volume = "123",
pages = "57--64",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams & Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - High-Risk and Low-Risk Human Papillomavirus and the Absolute Risk of Cervical Intraepithelial Neoplasia or Cancer

AU - Thomsen, Louise T

AU - Frederiksen, Kirsten

AU - Munk, Christian

AU - Junge, Jette

AU - Castle, Philip E

AU - Iftner, Thomas

AU - Kjaer, Susanne K

PY - 2014/1

Y1 - 2014/1

N2 - OBJECTIVE: To determine the absolute risk of cervical intraepithelial neoplasia (CIN) grade 3 or cervical cancer (CIN 3 or worse) after detection of low-risk human papillomavirus (HPV) and after a negative high-risk HPV test.METHODS: In this prospective cohort study, consecutive liquid-based cervical cytology samples were collected from women screened for cervical cancer in Copenhagen, Denmark, during 2002-2005. Samples were tested with a clinical test for 13 high-risk and five low-risk HPV types. The cohort (N=35,539; aged 14-90 years) was monitored in a nationwide pathology register for up to 10.5 years for development of CIN 3 or worse.RESULTS: The 8-year absolute risk of CIN 3 or worse was 1.1% (95% confidence interval [CI] 1.0-1.3%) for HPV-negative women; 1.7% (0.8-2.6%) for low-risk HPV-positive women without concurrent high-risk HPV; 17.4% (16.4-18.5%) for high-risk HPV-positive women without concurrent low-risk HPV; and 15.9% (13.5-18.3%) for women with concurrent high-risk and low-risk HPV. The 8-year absolute risk of CIN 3 or worse after a negative high-risk HPV test (irrespective of low-risk HPV status) was lower than after a normal cytology result among women aged younger than 30 years (3.5% [95% CI, 2.9-4.0%] compared with 6.9% [6.2-7.5%], P<.001) and women aged 30 years or older (0.7% [95% CI, 0.6-0.9%] compared with 1.8% [95% CI, 1.6-2.0%], P<.001).CONCLUSION: A negative high-risk HPV test provides greater long-term reassurance against CIN 3 or worse than normal cytology. Detection of low-risk HPV does not predict CIN 3 or worse. Cervical cancer screening should not include testing for low-risk HPV types.LEVEL OF EVIDENCE: II.

AB - OBJECTIVE: To determine the absolute risk of cervical intraepithelial neoplasia (CIN) grade 3 or cervical cancer (CIN 3 or worse) after detection of low-risk human papillomavirus (HPV) and after a negative high-risk HPV test.METHODS: In this prospective cohort study, consecutive liquid-based cervical cytology samples were collected from women screened for cervical cancer in Copenhagen, Denmark, during 2002-2005. Samples were tested with a clinical test for 13 high-risk and five low-risk HPV types. The cohort (N=35,539; aged 14-90 years) was monitored in a nationwide pathology register for up to 10.5 years for development of CIN 3 or worse.RESULTS: The 8-year absolute risk of CIN 3 or worse was 1.1% (95% confidence interval [CI] 1.0-1.3%) for HPV-negative women; 1.7% (0.8-2.6%) for low-risk HPV-positive women without concurrent high-risk HPV; 17.4% (16.4-18.5%) for high-risk HPV-positive women without concurrent low-risk HPV; and 15.9% (13.5-18.3%) for women with concurrent high-risk and low-risk HPV. The 8-year absolute risk of CIN 3 or worse after a negative high-risk HPV test (irrespective of low-risk HPV status) was lower than after a normal cytology result among women aged younger than 30 years (3.5% [95% CI, 2.9-4.0%] compared with 6.9% [6.2-7.5%], P<.001) and women aged 30 years or older (0.7% [95% CI, 0.6-0.9%] compared with 1.8% [95% CI, 1.6-2.0%], P<.001).CONCLUSION: A negative high-risk HPV test provides greater long-term reassurance against CIN 3 or worse than normal cytology. Detection of low-risk HPV does not predict CIN 3 or worse. Cervical cancer screening should not include testing for low-risk HPV types.LEVEL OF EVIDENCE: II.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Cervical Intraepithelial Neoplasia

KW - Cervix Uteri

KW - Denmark

KW - Female

KW - Humans

KW - Middle Aged

KW - Papillomaviridae

KW - Prospective Studies

KW - Risk Assessment

KW - Uterine Cervical Neoplasms

KW - Young Adult

U2 - 10.1097/AOG.0000000000000056

DO - 10.1097/AOG.0000000000000056

M3 - Journal article

C2 - 24463664

VL - 123

SP - 57

EP - 64

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 1

ER -

ID: 138171967