Glial and neuronal control of brain blood flow

Research output: Contribution to journal › Journal article › Research › peer-review

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Glial and neuronal control of brain blood flow. / Attwell, David; Buchan, Alastair M; Charpak, Serge; Lauritzen, Martin; Macvicar, Brian A; Newman, Eric A.

In: Nature, Vol. 468, No. 7321, 2010, p. 232-243.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Attwell, D, Buchan, AM, Charpak, S, Lauritzen, M, Macvicar, BA & Newman, EA 2010, 'Glial and neuronal control of brain blood flow', Nature, vol. 468, no. 7321, pp. 232-243. https://doi.org/10.1038/nature09613

APA

Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., Macvicar, B. A., & Newman, E. A. (2010). Glial and neuronal control of brain blood flow. Nature, 468(7321), 232-243. https://doi.org/10.1038/nature09613

Vancouver

Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, Newman EA. Glial and neuronal control of brain blood flow. Nature. 2010;468(7321):232-243. https://doi.org/10.1038/nature09613

Author

Attwell, David ; Buchan, Alastair M ; Charpak, Serge ; Lauritzen, Martin ; Macvicar, Brian A ; Newman, Eric A. / Glial and neuronal control of brain blood flow. In: Nature. 2010 ; Vol. 468, No. 7321. pp. 232-243.

Bibtex

@article{2cfef6066bcd4782b5e277e0777577ba,
title = "Glial and neuronal control of brain blood flow",
abstract = "Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.",
author = "David Attwell and Buchan, {Alastair M} and Serge Charpak and Martin Lauritzen and Macvicar, {Brian A} and Newman, {Eric A}",
year = "2010",
doi = "10.1038/nature09613",
language = "English",
volume = "468",
pages = "232--243",
journal = "Nature",
issn = "0028-0836",
publisher = "nature publishing group",
number = "7321",

}

RIS

TY - JOUR

T1 - Glial and neuronal control of brain blood flow

AU - Attwell, David

AU - Buchan, Alastair M

AU - Charpak, Serge

AU - Lauritzen, Martin

AU - Macvicar, Brian A

AU - Newman, Eric A

PY - 2010

Y1 - 2010

N2 - Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.

AB - Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.

U2 - 10.1038/nature09613

DO - 10.1038/nature09613

M3 - Journal article

VL - 468

SP - 232

EP - 243

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7321

ER -

ID: 34181870