Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond

Research output: Contribution to journal › Review › Research › peer-review

Standard

Genetic susceptibility to type 2 diabetes and obesity : from genome-wide association studies to rare variants and beyond. / Grarup, Niels; Sandholt, Camilla H; Hansen, Torben; Pedersen, Oluf.

In: Diabetologia, Vol. 57, No. 8, 08.2014, p. 1528-41.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Grarup, N, Sandholt, CH, Hansen, T & Pedersen, O 2014, 'Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond', Diabetologia, vol. 57, no. 8, pp. 1528-41. https://doi.org/10.1007/s00125-014-3270-4

APA

Grarup, N., Sandholt, C. H., Hansen, T., & Pedersen, O. (2014). Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond. Diabetologia, 57(8), 1528-41. https://doi.org/10.1007/s00125-014-3270-4

Vancouver

Grarup N, Sandholt CH, Hansen T, Pedersen O. Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond. Diabetologia. 2014 Aug;57(8):1528-41. https://doi.org/10.1007/s00125-014-3270-4

Author

Grarup, Niels ; Sandholt, Camilla H ; Hansen, Torben ; Pedersen, Oluf. / Genetic susceptibility to type 2 diabetes and obesity : from genome-wide association studies to rare variants and beyond. In: Diabetologia. 2014 ; Vol. 57, No. 8. pp. 1528-41.

Bibtex

@article{8cd60d27503742cc91a567079409740f,
title = "Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond",
abstract = "During the past 7 years, genome-wide association studies have shed light on the contribution of common genomic variants to the genetic architecture of type 2 diabetes, obesity and related intermediate phenotypes. The discoveries have firmly established more than 175 genomic loci associated with these phenotypes. Despite the tight correlation between type 2 diabetes and obesity, these conditions do not appear to share a common genetic background, since they have few genetic risk loci in common. The recent genetic discoveries do however highlight specific details of the interplay between the pathogenesis of type 2 diabetes, insulin resistance and obesity. The focus is currently shifting towards investigations of data from targeted array-based genotyping and exome and genome sequencing to study the individual and combined effect of low-frequency and rare variants in metabolic disease. Here we review recent progress as regards the concepts, methodologies and derived outcomes of studies of the genetics of type 2 diabetes and obesity, and discuss avenues to be investigated in the future within this research field.",
author = "Niels Grarup and Sandholt, {Camilla H} and Torben Hansen and Oluf Pedersen",
year = "2014",
month = aug,
doi = "10.1007/s00125-014-3270-4",
language = "English",
volume = "57",
pages = "1528--41",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Genetic susceptibility to type 2 diabetes and obesity

T2 - from genome-wide association studies to rare variants and beyond

AU - Grarup, Niels

AU - Sandholt, Camilla H

AU - Hansen, Torben

AU - Pedersen, Oluf

PY - 2014/8

Y1 - 2014/8

N2 - During the past 7 years, genome-wide association studies have shed light on the contribution of common genomic variants to the genetic architecture of type 2 diabetes, obesity and related intermediate phenotypes. The discoveries have firmly established more than 175 genomic loci associated with these phenotypes. Despite the tight correlation between type 2 diabetes and obesity, these conditions do not appear to share a common genetic background, since they have few genetic risk loci in common. The recent genetic discoveries do however highlight specific details of the interplay between the pathogenesis of type 2 diabetes, insulin resistance and obesity. The focus is currently shifting towards investigations of data from targeted array-based genotyping and exome and genome sequencing to study the individual and combined effect of low-frequency and rare variants in metabolic disease. Here we review recent progress as regards the concepts, methodologies and derived outcomes of studies of the genetics of type 2 diabetes and obesity, and discuss avenues to be investigated in the future within this research field.

AB - During the past 7 years, genome-wide association studies have shed light on the contribution of common genomic variants to the genetic architecture of type 2 diabetes, obesity and related intermediate phenotypes. The discoveries have firmly established more than 175 genomic loci associated with these phenotypes. Despite the tight correlation between type 2 diabetes and obesity, these conditions do not appear to share a common genetic background, since they have few genetic risk loci in common. The recent genetic discoveries do however highlight specific details of the interplay between the pathogenesis of type 2 diabetes, insulin resistance and obesity. The focus is currently shifting towards investigations of data from targeted array-based genotyping and exome and genome sequencing to study the individual and combined effect of low-frequency and rare variants in metabolic disease. Here we review recent progress as regards the concepts, methodologies and derived outcomes of studies of the genetics of type 2 diabetes and obesity, and discuss avenues to be investigated in the future within this research field.

U2 - 10.1007/s00125-014-3270-4

DO - 10.1007/s00125-014-3270-4

M3 - Review

C2 - 24859358

VL - 57

SP - 1528

EP - 1541

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 8

ER -

ID: 120783417