Geminin: a major DNA replication safeguard in higher eukaryotes.
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Geminin: a major DNA replication safeguard in higher eukaryotes. / Melixetian, Marina; Helin, Kristian.
In: Cell Cycle, Vol. 3, No. 8, 2004, p. 1002-4.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Geminin: a major DNA replication safeguard in higher eukaryotes.
AU - Melixetian, Marina
AU - Helin, Kristian
N1 - Keywords: Animals; Cell Cycle Proteins; DNA Replication; Eukaryotic Cells; Humans
PY - 2004
Y1 - 2004
N2 - Eukaryotes have evolved multiple mechanisms to restrict DNA replication to once per cell cycle. These mechanisms prevent relicensing of origins of replication after initiation of DNA replication in S phase until the end of mitosis. Most of our knowledge of mechanisms controlling prereplication complex (preRC) formation are based on studies from yeast and Xenopus, while much less is known for mammalian cells. Here we discuss our recent data demonstrating that Geminin is required for preventing rereplication in human normal and cancer cells.
AB - Eukaryotes have evolved multiple mechanisms to restrict DNA replication to once per cell cycle. These mechanisms prevent relicensing of origins of replication after initiation of DNA replication in S phase until the end of mitosis. Most of our knowledge of mechanisms controlling prereplication complex (preRC) formation are based on studies from yeast and Xenopus, while much less is known for mammalian cells. Here we discuss our recent data demonstrating that Geminin is required for preventing rereplication in human normal and cancer cells.
M3 - Review
C2 - 15280663
VL - 3
SP - 1002
EP - 1004
JO - Cell Cycle
JF - Cell Cycle
SN - 1538-4101
IS - 8
ER -
ID: 5035464