GABA, a natural immunomodulator of T lymphocytes

Research output: Contribution to journal › Journal article › Research › peer-review

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GABA, a natural immunomodulator of T lymphocytes. / Bjurstöm, Helen; Wang, Junyang; Ericsson, Ida; Bengtsson, Martin; Liu, Yawei; Kumar-Mendu, Suresh; Issazadeh-Navikas, Shohreh; Birnir, Bryndis.

In: Journal of Neuroimmunology, Vol. 205, No. 1-2, 2008, p. 44-50.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bjurstöm, H, Wang, J, Ericsson, I, Bengtsson, M, Liu, Y, Kumar-Mendu, S, Issazadeh-Navikas, S & Birnir, B 2008, 'GABA, a natural immunomodulator of T lymphocytes', Journal of Neuroimmunology, vol. 205, no. 1-2, pp. 44-50. https://doi.org/10.1016/j.jneuroim.2008.08.017

APA

Bjurstöm, H., Wang, J., Ericsson, I., Bengtsson, M., Liu, Y., Kumar-Mendu, S., Issazadeh-Navikas, S., & Birnir, B. (2008). GABA, a natural immunomodulator of T lymphocytes. Journal of Neuroimmunology, 205(1-2), 44-50. https://doi.org/10.1016/j.jneuroim.2008.08.017

Vancouver

Bjurstöm H, Wang J, Ericsson I, Bengtsson M, Liu Y, Kumar-Mendu S et al. GABA, a natural immunomodulator of T lymphocytes. Journal of Neuroimmunology. 2008;205(1-2):44-50. https://doi.org/10.1016/j.jneuroim.2008.08.017

Author

Bjurstöm, Helen ; Wang, Junyang ; Ericsson, Ida ; Bengtsson, Martin ; Liu, Yawei ; Kumar-Mendu, Suresh ; Issazadeh-Navikas, Shohreh ; Birnir, Bryndis. / GABA, a natural immunomodulator of T lymphocytes. In: Journal of Neuroimmunology. 2008 ; Vol. 205, No. 1-2. pp. 44-50.

Bibtex

@article{17e604d0eba311ddbf70000ea68e967b,
title = "GABA, a natural immunomodulator of T lymphocytes",
abstract = "gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 microM), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha1, alpha4, beta2, beta3, gamma1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 microM GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory.",
author = "Helen Bjurst{\"o}m and Junyang Wang and Ida Ericsson and Martin Bengtsson and Yawei Liu and Suresh Kumar-Mendu and Shohreh Issazadeh-Navikas and Bryndis Birnir",
year = "2008",
doi = "10.1016/j.jneuroim.2008.08.017",
language = "English",
volume = "205",
pages = "44--50",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - GABA, a natural immunomodulator of T lymphocytes

AU - Bjurstöm, Helen

AU - Wang, Junyang

AU - Ericsson, Ida

AU - Bengtsson, Martin

AU - Liu, Yawei

AU - Kumar-Mendu, Suresh

AU - Issazadeh-Navikas, Shohreh

AU - Birnir, Bryndis

PY - 2008

Y1 - 2008

N2 - gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 microM), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha1, alpha4, beta2, beta3, gamma1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 microM GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory.

AB - gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 microM), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha1, alpha4, beta2, beta3, gamma1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 microM GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory.

U2 - 10.1016/j.jneuroim.2008.08.017

DO - 10.1016/j.jneuroim.2008.08.017

M3 - Journal article

C2 - 18954912

VL - 205

SP - 44

EP - 50

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -

ID: 9938430