TY - JOUR

T1 - Functional body composition and related aspects in research on obesity and cachexia

T2 - report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany

AU - Müller, M J

AU - Baracos, V

AU - Bosy-Westphal, A

AU - Dulloo, A G

AU - Eckel, J

AU - Fearon, K C H

AU - Hall, K D

AU - Pietrobelli, A

AU - Sørensen, T I A

AU - Speakman, J

AU - Trayhurn, P

AU - Visser, M

AU - Heymsfield, S B

N1 - © 2014 The Authors. obesity reviews © 2014 World Obesity.

PY - 2014/8

Y1 - 2014/8

N2 - The 12th Stock Conference addressed body composition and related functions in two extreme situations, obesity and cancer cachexia. The concept of 'functional body composition' integrates body components into regulatory systems relating the mass of organs and tissues to corresponding in vivo functions and metabolic processes. This concept adds to an understanding of organ/tissue mass and function in the context of metabolic adaptations to weight change and disease. During weight gain and loss, there are associated changes in individual body components while the relationships between organ and tissue mass are fixed. Thus an understanding of body weight regulation involves an examination of the relationships between organs and tissues rather than individual organ and tissue masses only. The between organ/tissue mass relationships are associated with and explained by crosstalks between organs and tissues mediated by cytokines, hormones and metabolites that are coupled with changes in body weight, composition and function as observed in obesity and cancer cachexia. In addition to established roles in intermediary metabolism, cell function and inflammation, organ-tissue crosstalk mediators are determinants of body composition and its change with weight gain and loss. The 12th Stock Conference supported Michael Stocks' concept of gaining new insights by integrating research ideas from obesity and cancer cachexia. The conference presentations provide an in-depth understanding of body composition and metabolism.

AB - The 12th Stock Conference addressed body composition and related functions in two extreme situations, obesity and cancer cachexia. The concept of 'functional body composition' integrates body components into regulatory systems relating the mass of organs and tissues to corresponding in vivo functions and metabolic processes. This concept adds to an understanding of organ/tissue mass and function in the context of metabolic adaptations to weight change and disease. During weight gain and loss, there are associated changes in individual body components while the relationships between organ and tissue mass are fixed. Thus an understanding of body weight regulation involves an examination of the relationships between organs and tissues rather than individual organ and tissue masses only. The between organ/tissue mass relationships are associated with and explained by crosstalks between organs and tissues mediated by cytokines, hormones and metabolites that are coupled with changes in body weight, composition and function as observed in obesity and cancer cachexia. In addition to established roles in intermediary metabolism, cell function and inflammation, organ-tissue crosstalk mediators are determinants of body composition and its change with weight gain and loss. The 12th Stock Conference supported Michael Stocks' concept of gaining new insights by integrating research ideas from obesity and cancer cachexia. The conference presentations provide an in-depth understanding of body composition and metabolism.

KW - Adipokines

KW - Adipose Tissue

KW - Animals

KW - Body Composition

KW - Body Weight

KW - Cachexia

KW - Congresses as Topic

KW - Disease Models, Animal

KW - Energy Metabolism

KW - Germany

KW - Humans

KW - Muscle, Skeletal

KW - Obesity

U2 - 10.1111/obr.12187

DO - 10.1111/obr.12187

M3 - Review

C2 - 24835453

VL - 15

SP - 640

EP - 656

JO - Obesity Reviews

JF - Obesity Reviews

SN - 1467-7881

IS - 8

ER -