Findings on the atopic triad from a Danish twin registry

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Standard

Findings on the atopic triad from a Danish twin registry. / Thomsen, SF; Ulrik, Charlotte Suppli; Kyvik, KO; Skadhauge, LR; Steffensen, I; Backer, V.

In: International Journal of Tuberculosis and Lung Disease, Vol. 10, No. 11, 2006, p. 1268-72.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Thomsen, SF, Ulrik, CS, Kyvik, KO, Skadhauge, LR, Steffensen, I & Backer, V 2006, 'Findings on the atopic triad from a Danish twin registry', International Journal of Tuberculosis and Lung Disease, vol. 10, no. 11, pp. 1268-72. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17131787&query_hl=10&itool=pubmed_docsum>

APA

Thomsen, SF., Ulrik, C. S., Kyvik, KO., Skadhauge, LR., Steffensen, I., & Backer, V. (2006). Findings on the atopic triad from a Danish twin registry. International Journal of Tuberculosis and Lung Disease, 10(11), 1268-72. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17131787&query_hl=10&itool=pubmed_docsum

Vancouver

Thomsen SF, Ulrik CS, Kyvik KO, Skadhauge LR, Steffensen I, Backer V. Findings on the atopic triad from a Danish twin registry. International Journal of Tuberculosis and Lung Disease. 2006;10(11):1268-72.

Author

Thomsen, SF ; Ulrik, Charlotte Suppli ; Kyvik, KO ; Skadhauge, LR ; Steffensen, I ; Backer, V. / Findings on the atopic triad from a Danish twin registry. In: International Journal of Tuberculosis and Lung Disease. 2006 ; Vol. 10, No. 11. pp. 1268-72.

Bibtex

@article{3c96e16f42db4b8f842776c24cc89a6a,
title = "Findings on the atopic triad from a Danish twin registry",
abstract = "OBJECTIVE: To estimate to what extent the same genetic and environmental risk factors influence asthma, hay fever and eczema. DESIGN: From the nationwide Danish Twin Registry, twin cohorts born between 1953 and 1982 were contacted for a questionnaire survey, and a total of 29 183 twin individuals (86%) responded. Subjects were classified as cases when responding affirmatively to three questions about the lifetime occurrence of asthma, hay fever and eczema. Variance components twin analysis was conducted using maximum likelihood methods. RESULTS: The phenotypic (within-subject) correlations in liability between the different diseases were 0.57 (95% CI 0.54-0.59) for asthma and hay fever, 0.40 (95% CI 0.36-0.42) for asthma and eczema, and 0.33 (95% CI 0.29-0.36) for hay fever and eczema. Decomposition of these correlations into their genetic and environmental contributions showed that shared genes explained between 70% and 85% of the correlation between the different diseases. The remaining parts were explained by environmental factors shared between the diseases. CONCLUSION: To a large extent, atopic diseases share a common genetic background, although disease-specific genes also play a considerable role. These results can prove informative when counselling families with atopy, and may furthermore be used to guide the search for pleiotropic genes of importance for these diseases.",
author = "SF Thomsen and Ulrik, {Charlotte Suppli} and KO Kyvik and LR Skadhauge and I Steffensen and V Backer",
year = "2006",
language = "English",
volume = "10",
pages = "1268--72",
journal = "International Journal of Tuberculosis and Lung Disease",
issn = "1027-3719",
publisher = "International Union against Tuberculosis and Lung Disease (I U A T L D)",
number = "11",

}

RIS

TY - JOUR

T1 - Findings on the atopic triad from a Danish twin registry

AU - Thomsen, SF

AU - Ulrik, Charlotte Suppli

AU - Kyvik, KO

AU - Skadhauge, LR

AU - Steffensen, I

AU - Backer, V

PY - 2006

Y1 - 2006

N2 - OBJECTIVE: To estimate to what extent the same genetic and environmental risk factors influence asthma, hay fever and eczema. DESIGN: From the nationwide Danish Twin Registry, twin cohorts born between 1953 and 1982 were contacted for a questionnaire survey, and a total of 29 183 twin individuals (86%) responded. Subjects were classified as cases when responding affirmatively to three questions about the lifetime occurrence of asthma, hay fever and eczema. Variance components twin analysis was conducted using maximum likelihood methods. RESULTS: The phenotypic (within-subject) correlations in liability between the different diseases were 0.57 (95% CI 0.54-0.59) for asthma and hay fever, 0.40 (95% CI 0.36-0.42) for asthma and eczema, and 0.33 (95% CI 0.29-0.36) for hay fever and eczema. Decomposition of these correlations into their genetic and environmental contributions showed that shared genes explained between 70% and 85% of the correlation between the different diseases. The remaining parts were explained by environmental factors shared between the diseases. CONCLUSION: To a large extent, atopic diseases share a common genetic background, although disease-specific genes also play a considerable role. These results can prove informative when counselling families with atopy, and may furthermore be used to guide the search for pleiotropic genes of importance for these diseases.

AB - OBJECTIVE: To estimate to what extent the same genetic and environmental risk factors influence asthma, hay fever and eczema. DESIGN: From the nationwide Danish Twin Registry, twin cohorts born between 1953 and 1982 were contacted for a questionnaire survey, and a total of 29 183 twin individuals (86%) responded. Subjects were classified as cases when responding affirmatively to three questions about the lifetime occurrence of asthma, hay fever and eczema. Variance components twin analysis was conducted using maximum likelihood methods. RESULTS: The phenotypic (within-subject) correlations in liability between the different diseases were 0.57 (95% CI 0.54-0.59) for asthma and hay fever, 0.40 (95% CI 0.36-0.42) for asthma and eczema, and 0.33 (95% CI 0.29-0.36) for hay fever and eczema. Decomposition of these correlations into their genetic and environmental contributions showed that shared genes explained between 70% and 85% of the correlation between the different diseases. The remaining parts were explained by environmental factors shared between the diseases. CONCLUSION: To a large extent, atopic diseases share a common genetic background, although disease-specific genes also play a considerable role. These results can prove informative when counselling families with atopy, and may furthermore be used to guide the search for pleiotropic genes of importance for these diseases.

M3 - Journal article

VL - 10

SP - 1268

EP - 1272

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

SN - 1027-3719

IS - 11

ER -

ID: 34149176