Expansion of microsatellite in the thyroid hormone receptor-alpha1 gene linked to increased receptor expression and less aggressive thyroid cancer.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Expansion of microsatellite in the thyroid hormone receptor-alpha1 gene linked to increased receptor expression and less aggressive thyroid cancer. / Onda, Masamitsu; Li, Daisy; Suzuki, Shinichi; Nakamura, Izumi; Takenoshita, Seiichi; Brogren, Carl-Henrik; Stampanoni, Sabina; Rampino, Nicholas.

In: Clinical Cancer Research, Vol. 8, No. 9, 2002, p. 2870-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Onda, M, Li, D, Suzuki, S, Nakamura, I, Takenoshita, S, Brogren, C-H, Stampanoni, S & Rampino, N 2002, 'Expansion of microsatellite in the thyroid hormone receptor-alpha1 gene linked to increased receptor expression and less aggressive thyroid cancer.', Clinical Cancer Research, vol. 8, no. 9, pp. 2870-4.

APA

Onda, M., Li, D., Suzuki, S., Nakamura, I., Takenoshita, S., Brogren, C-H., Stampanoni, S., & Rampino, N. (2002). Expansion of microsatellite in the thyroid hormone receptor-alpha1 gene linked to increased receptor expression and less aggressive thyroid cancer. Clinical Cancer Research, 8(9), 2870-4.

Vancouver

Onda M, Li D, Suzuki S, Nakamura I, Takenoshita S, Brogren C-H et al. Expansion of microsatellite in the thyroid hormone receptor-alpha1 gene linked to increased receptor expression and less aggressive thyroid cancer. Clinical Cancer Research. 2002;8(9):2870-4.

Author

Onda, Masamitsu ; Li, Daisy ; Suzuki, Shinichi ; Nakamura, Izumi ; Takenoshita, Seiichi ; Brogren, Carl-Henrik ; Stampanoni, Sabina ; Rampino, Nicholas. / Expansion of microsatellite in the thyroid hormone receptor-alpha1 gene linked to increased receptor expression and less aggressive thyroid cancer. In: Clinical Cancer Research. 2002 ; Vol. 8, No. 9. pp. 2870-4.

Bibtex

@article{06b7bcc0acac11ddb5e9000ea68e967b,
title = "Expansion of microsatellite in the thyroid hormone receptor-alpha1 gene linked to increased receptor expression and less aggressive thyroid cancer.",
abstract = "PURPOSE: The purpose of this study was to determine whether the length of the THRA1 microsatellite, which resides in a noncoding portion of the thyroid hormone receptor-alpha1 gene, affects receptor expression and is linked to clinicopathological parameters in thyroid cancer. EXPERIMENTAL DESIGN: In 30 cases of surgically resected sporadic thyroid cancer, the length of the THRA1 microsatellite was determined by DNA sequence analysis, and expression of thyroid hormone receptor-alpha1 was assessed immunohistochemically in thin sections cut from tumor blocks. The length of THRA1 and expression of thyroid hormone receptor-alpha1 were also assessed in seven cancer cell lines. Regression analysis was used to gauge the correlation between the size of THRA1 and receptor expression. Multivariate analysis was used to test for links to the clinical parameters of gender, age, histology, stage, nodal involvement, distant metastasis, extrathyroidal invasion and tumor-node-metastasis (TNM) classification. RESULTS: A statistically significant correlation between the length of THRA1 and thyroid hormone receptor-alpha1 expression was observed in both cell lines and primary thyroid cancers. Thyroid tumors that displayed higher than average thyroid hormone receptor-alpha1 expression had expanded THRA1 microsatellites and were less aggressive as judged by TNM ranking. A statistically significant correlation was also found between low thyroid hormone receptor-alpha1 expression and more aggressive thyroid cancer, as judged by extrathyroidal invasion and nodal involvement. CONCLUSIONS: Less aggressive thyroid cancer was found to be linked to increased thyroid hormone receptor-alpha1 expression and an expanded THRA1 microsatellite.",
author = "Masamitsu Onda and Daisy Li and Shinichi Suzuki and Izumi Nakamura and Seiichi Takenoshita and Carl-Henrik Brogren and Sabina Stampanoni and Nicholas Rampino",
note = "Keywords: Adenocarcinoma, Follicular; Carcinoma, Papillary; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Microsatellite Repeats; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Receptors, Thyroid Hormone; Thyroid Neoplasms; Tumor Cells, Cultured",
year = "2002",
language = "English",
volume = "8",
pages = "2870--4",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research (A A C R)",
number = "9",

}

RIS

TY - JOUR

T1 - Expansion of microsatellite in the thyroid hormone receptor-alpha1 gene linked to increased receptor expression and less aggressive thyroid cancer.

AU - Onda, Masamitsu

AU - Li, Daisy

AU - Suzuki, Shinichi

AU - Nakamura, Izumi

AU - Takenoshita, Seiichi

AU - Brogren, Carl-Henrik

AU - Stampanoni, Sabina

AU - Rampino, Nicholas

N1 - Keywords: Adenocarcinoma, Follicular; Carcinoma, Papillary; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Microsatellite Repeats; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Receptors, Thyroid Hormone; Thyroid Neoplasms; Tumor Cells, Cultured

PY - 2002

Y1 - 2002

N2 - PURPOSE: The purpose of this study was to determine whether the length of the THRA1 microsatellite, which resides in a noncoding portion of the thyroid hormone receptor-alpha1 gene, affects receptor expression and is linked to clinicopathological parameters in thyroid cancer. EXPERIMENTAL DESIGN: In 30 cases of surgically resected sporadic thyroid cancer, the length of the THRA1 microsatellite was determined by DNA sequence analysis, and expression of thyroid hormone receptor-alpha1 was assessed immunohistochemically in thin sections cut from tumor blocks. The length of THRA1 and expression of thyroid hormone receptor-alpha1 were also assessed in seven cancer cell lines. Regression analysis was used to gauge the correlation between the size of THRA1 and receptor expression. Multivariate analysis was used to test for links to the clinical parameters of gender, age, histology, stage, nodal involvement, distant metastasis, extrathyroidal invasion and tumor-node-metastasis (TNM) classification. RESULTS: A statistically significant correlation between the length of THRA1 and thyroid hormone receptor-alpha1 expression was observed in both cell lines and primary thyroid cancers. Thyroid tumors that displayed higher than average thyroid hormone receptor-alpha1 expression had expanded THRA1 microsatellites and were less aggressive as judged by TNM ranking. A statistically significant correlation was also found between low thyroid hormone receptor-alpha1 expression and more aggressive thyroid cancer, as judged by extrathyroidal invasion and nodal involvement. CONCLUSIONS: Less aggressive thyroid cancer was found to be linked to increased thyroid hormone receptor-alpha1 expression and an expanded THRA1 microsatellite.

AB - PURPOSE: The purpose of this study was to determine whether the length of the THRA1 microsatellite, which resides in a noncoding portion of the thyroid hormone receptor-alpha1 gene, affects receptor expression and is linked to clinicopathological parameters in thyroid cancer. EXPERIMENTAL DESIGN: In 30 cases of surgically resected sporadic thyroid cancer, the length of the THRA1 microsatellite was determined by DNA sequence analysis, and expression of thyroid hormone receptor-alpha1 was assessed immunohistochemically in thin sections cut from tumor blocks. The length of THRA1 and expression of thyroid hormone receptor-alpha1 were also assessed in seven cancer cell lines. Regression analysis was used to gauge the correlation between the size of THRA1 and receptor expression. Multivariate analysis was used to test for links to the clinical parameters of gender, age, histology, stage, nodal involvement, distant metastasis, extrathyroidal invasion and tumor-node-metastasis (TNM) classification. RESULTS: A statistically significant correlation between the length of THRA1 and thyroid hormone receptor-alpha1 expression was observed in both cell lines and primary thyroid cancers. Thyroid tumors that displayed higher than average thyroid hormone receptor-alpha1 expression had expanded THRA1 microsatellites and were less aggressive as judged by TNM ranking. A statistically significant correlation was also found between low thyroid hormone receptor-alpha1 expression and more aggressive thyroid cancer, as judged by extrathyroidal invasion and nodal involvement. CONCLUSIONS: Less aggressive thyroid cancer was found to be linked to increased thyroid hormone receptor-alpha1 expression and an expanded THRA1 microsatellite.

M3 - Journal article

C2 - 12231529

VL - 8

SP - 2870

EP - 2874

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 9

ER -

ID: 8463140