Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro

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Effects of hyperammonemia on brain energy metabolism : controversial findings in vivo and in vitro. / Schousboe, Arne; Waagepetersen, Helle S.; Leke, Renata; Bak, Lasse K.

In: Metabolic Brain Disease, Vol. 29, No. 4, 01.03.2014, p. 913-917.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Schousboe, A, Waagepetersen, HS, Leke, R & Bak, LK 2014, 'Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro', Metabolic Brain Disease, vol. 29, no. 4, pp. 913-917. https://doi.org/10.1007/s11011-014-9513-8

APA

Schousboe, A., Waagepetersen, H. S., Leke, R., & Bak, L. K. (2014). Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro. Metabolic Brain Disease, 29(4), 913-917. https://doi.org/10.1007/s11011-014-9513-8

Vancouver

Schousboe A, Waagepetersen HS, Leke R, Bak LK. Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro. Metabolic Brain Disease. 2014 Mar 1;29(4):913-917. https://doi.org/10.1007/s11011-014-9513-8

Author

Schousboe, Arne ; Waagepetersen, Helle S. ; Leke, Renata ; Bak, Lasse K. / Effects of hyperammonemia on brain energy metabolism : controversial findings in vivo and in vitro. In: Metabolic Brain Disease. 2014 ; Vol. 29, No. 4. pp. 913-917.

Bibtex

@article{41612279a0a546a09da19bb845ae9067,
title = "Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro",
abstract = "The literature related to the effects of elevated plasma ammonia levels on brain energy metabolism is abundant, but heterogeneous in terms of the conclusions. Thus, some studies claim that ammonia has a direct, inhibitory effect on energy metabolism whereas others find no such correlation. In this review, we discuss both recent and older literature related to this controversial topic. We find that it has been consistently reported that hepatic encephalopathy and concomitant hyperammonemia lead to reduced cerebral oxygen consumption. However, this may not be directly linked to an effect of ammonia but related to the fact that hepatic encephalopathy is always associated with reduced brain activity, a condition clearly characterized by a decreased CMRO2. Whether this may be related to changes in GABAergic function remains to be elucidated.",
author = "Arne Schousboe and Waagepetersen, {Helle S.} and Renata Leke and Bak, {Lasse K}",
year = "2014",
month = mar,
day = "1",
doi = "10.1007/s11011-014-9513-8",
language = "English",
volume = "29",
pages = "913--917",
journal = "Metabolic Brain Disease",
issn = "0885-7490",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of hyperammonemia on brain energy metabolism

T2 - controversial findings in vivo and in vitro

AU - Schousboe, Arne

AU - Waagepetersen, Helle S.

AU - Leke, Renata

AU - Bak, Lasse K

PY - 2014/3/1

Y1 - 2014/3/1

N2 - The literature related to the effects of elevated plasma ammonia levels on brain energy metabolism is abundant, but heterogeneous in terms of the conclusions. Thus, some studies claim that ammonia has a direct, inhibitory effect on energy metabolism whereas others find no such correlation. In this review, we discuss both recent and older literature related to this controversial topic. We find that it has been consistently reported that hepatic encephalopathy and concomitant hyperammonemia lead to reduced cerebral oxygen consumption. However, this may not be directly linked to an effect of ammonia but related to the fact that hepatic encephalopathy is always associated with reduced brain activity, a condition clearly characterized by a decreased CMRO2. Whether this may be related to changes in GABAergic function remains to be elucidated.

AB - The literature related to the effects of elevated plasma ammonia levels on brain energy metabolism is abundant, but heterogeneous in terms of the conclusions. Thus, some studies claim that ammonia has a direct, inhibitory effect on energy metabolism whereas others find no such correlation. In this review, we discuss both recent and older literature related to this controversial topic. We find that it has been consistently reported that hepatic encephalopathy and concomitant hyperammonemia lead to reduced cerebral oxygen consumption. However, this may not be directly linked to an effect of ammonia but related to the fact that hepatic encephalopathy is always associated with reduced brain activity, a condition clearly characterized by a decreased CMRO2. Whether this may be related to changes in GABAergic function remains to be elucidated.

U2 - 10.1007/s11011-014-9513-8

DO - 10.1007/s11011-014-9513-8

M3 - Journal article

C2 - 24577633

VL - 29

SP - 913

EP - 917

JO - Metabolic Brain Disease

JF - Metabolic Brain Disease

SN - 0885-7490

IS - 4

ER -

ID: 120585729