Dopamine replacement modulates oscillatory coupling between premotor and motor cortical areas in Parkinson's disease
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Dopamine replacement modulates oscillatory coupling between premotor and motor cortical areas in Parkinson's disease. / Herz, Damian Marc; Florin, Esther; Christensen, Mark Schram; Reck, Christiane; Barbe, Michael Thomas; Tscheuschler, Maike Karoline; Tittgemeyer, Marc; Siebner, Hartwig Roman; Timmermann, Lars.
In: Cerebral Cortex, Vol. 24, No. 11, 2014, p. 2873-2883.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dopamine replacement modulates oscillatory coupling between premotor and motor cortical areas in Parkinson's disease
AU - Herz, Damian Marc
AU - Florin, Esther
AU - Christensen, Mark Schram
AU - Reck, Christiane
AU - Barbe, Michael Thomas
AU - Tscheuschler, Maike Karoline
AU - Tittgemeyer, Marc
AU - Siebner, Hartwig Roman
AU - Timmermann, Lars
N1 - CURIS 2014 NEXS 313
PY - 2014
Y1 - 2014
N2 - Efficient neural communication between premotor and motor cortical areas is critical for manual motor control. Here, we used high-density electroencephalography to study cortical connectivity in patients with Parkinson's disease (PD) and age-matched healthy controls while they performed repetitive movements of the right index finger at maximal repetition rate. Multiple source beamformer analysis and dynamic causal modeling were used to assess oscillatory coupling between the lateral premotor cortex (lPM), supplementary motor area (SMA), and primary motor cortex (M1) in the contralateral hemisphere. Elderly healthy controls showed task-related modulation in connections from lPM to SMA and M1, mainly within the γ-band (>30 Hz). Nonmedicated PD patients also showed task-related γ-γ coupling from lPM to M1, but γ coupling from lPM to SMA was absent. Levodopa reinstated physiological γ-γ coupling from lPM to SMA and significantly strengthened coupling in the feedback connection from M1 to lPM expressed as β-β as well as θ-β coupling. Enhancement in cross-frequency θ-β coupling from M1 to lPM was correlated with levodopa-induced improvement in motor function. The results show that PD is associated with an altered neural communication between premotor and motor cortical areas, which can be modulated by dopamine replacement.
AB - Efficient neural communication between premotor and motor cortical areas is critical for manual motor control. Here, we used high-density electroencephalography to study cortical connectivity in patients with Parkinson's disease (PD) and age-matched healthy controls while they performed repetitive movements of the right index finger at maximal repetition rate. Multiple source beamformer analysis and dynamic causal modeling were used to assess oscillatory coupling between the lateral premotor cortex (lPM), supplementary motor area (SMA), and primary motor cortex (M1) in the contralateral hemisphere. Elderly healthy controls showed task-related modulation in connections from lPM to SMA and M1, mainly within the γ-band (>30 Hz). Nonmedicated PD patients also showed task-related γ-γ coupling from lPM to M1, but γ coupling from lPM to SMA was absent. Levodopa reinstated physiological γ-γ coupling from lPM to SMA and significantly strengthened coupling in the feedback connection from M1 to lPM expressed as β-β as well as θ-β coupling. Enhancement in cross-frequency θ-β coupling from M1 to lPM was correlated with levodopa-induced improvement in motor function. The results show that PD is associated with an altered neural communication between premotor and motor cortical areas, which can be modulated by dopamine replacement.
U2 - 10.1093/cercor/bht140
DO - 10.1093/cercor/bht140
M3 - Journal article
C2 - 23733911
VL - 24
SP - 2873
EP - 2883
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 11
ER -
ID: 46127169