Do young adults with bipolar disorder benefit from early intervention?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Do young adults with bipolar disorder benefit from early intervention? / Kessing, Lars Vedel; Hansen, Hanne Vibe; Christensen, Ellen Margrethe; Dam, Henrik; Gluud, Christian; Wetterslev, Jørn; Early Intervention Affective Disorders (EIA) Trial Group.

In: Journal of Affective Disorders, Vol. 152-154, 01.2014, p. 403-408.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kessing, LV, Hansen, HV, Christensen, EM, Dam, H, Gluud, C, Wetterslev, J & Early Intervention Affective Disorders (EIA) Trial Group 2014, 'Do young adults with bipolar disorder benefit from early intervention?', Journal of Affective Disorders, vol. 152-154, pp. 403-408. https://doi.org/10.1016/j.jad.2013.10.001

APA

Kessing, L. V., Hansen, H. V., Christensen, E. M., Dam, H., Gluud, C., Wetterslev, J., & Early Intervention Affective Disorders (EIA) Trial Group (2014). Do young adults with bipolar disorder benefit from early intervention? Journal of Affective Disorders, 152-154, 403-408. https://doi.org/10.1016/j.jad.2013.10.001

Vancouver

Kessing LV, Hansen HV, Christensen EM, Dam H, Gluud C, Wetterslev J et al. Do young adults with bipolar disorder benefit from early intervention? Journal of Affective Disorders. 2014 Jan;152-154:403-408. https://doi.org/10.1016/j.jad.2013.10.001

Author

Kessing, Lars Vedel ; Hansen, Hanne Vibe ; Christensen, Ellen Margrethe ; Dam, Henrik ; Gluud, Christian ; Wetterslev, Jørn ; Early Intervention Affective Disorders (EIA) Trial Group. / Do young adults with bipolar disorder benefit from early intervention?. In: Journal of Affective Disorders. 2014 ; Vol. 152-154. pp. 403-408.

Bibtex

@article{6f574fbdac19471097e081d6d160fe76,
title = "Do young adults with bipolar disorder benefit from early intervention?",
abstract = "BACKGROUND: It is unknown whether young adults with bipolar disorder are able to benefit from early intervention combining optimised pharmacological treatment and group psychoeducation. The aim of the present report was to compare the effects of early intervention among patients with bipolar disorder aged 18-25 years to that of patients aged 26 years or older.METHODS: Patients were randomised to early treatment in a specialised outpatient mood disorder clinic versus standard care. The primary outcome was risk of psychiatric re-hospitalisation.RESULTS: A total of 158 patients with mania/bipolar disorder were included among whom 29 (18.4%) were between 18 and 25 years and 129 patients were 26 years or older. For both age groups, the point estimate of the hazard ratio of re-hospitalisation was insignificantly decreased for patients treated in the mood disorder clinic versus standard treatment but more so for patients between 18 and 25 years (HR 0.33, 95% CI 0.10-1.07; p=0.064) than for patients 26 years or older (HR 0.68, 95% CI 0.40-1.14, p=0.14). Younger adults treated in the mood disorder clinic used mood stabilisers and antipsychotics more in contrast to those treated in standard care. The differences between the estimates of effects did not reach significance in tests of interactions (p>0.2).LIMITATIONS: The study was based on a post hoc subgroup analysis and due to the small number of patients aged 18-25 years, type II errors cannot be excluded.CONCLUSIONS: Although not statistically different, the observed differences of the point estimates was surprisingly larger for young adults suggesting that young adults with bipolar disorder may benefit even more than older adults from early intervention combining pharmacological treatment and group psychoeducation.",
keywords = "Adolescent, Adult, Age Factors, Antimanic Agents, Antipsychotic Agents, Bipolar Disorder, Combined Modality Therapy, Early Medical Intervention, Female, Hospitalization, Humans, Male, Psychotherapy, Group, Young Adult",
author = "Kessing, {Lars Vedel} and Hansen, {Hanne Vibe} and Christensen, {Ellen Margrethe} and Henrik Dam and Christian Gluud and J{\o}rn Wetterslev and {Early Intervention Affective Disorders (EIA) Trial Group}",
note = "{\textcopyright} 2013 Elsevier B.V. All rights reserved.",
year = "2014",
month = jan,
doi = "10.1016/j.jad.2013.10.001",
language = "English",
volume = "152-154",
pages = "403--408",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Do young adults with bipolar disorder benefit from early intervention?

AU - Kessing, Lars Vedel

AU - Hansen, Hanne Vibe

AU - Christensen, Ellen Margrethe

AU - Dam, Henrik

AU - Gluud, Christian

AU - Wetterslev, Jørn

AU - Early Intervention Affective Disorders (EIA) Trial Group

N1 - © 2013 Elsevier B.V. All rights reserved.

PY - 2014/1

Y1 - 2014/1

N2 - BACKGROUND: It is unknown whether young adults with bipolar disorder are able to benefit from early intervention combining optimised pharmacological treatment and group psychoeducation. The aim of the present report was to compare the effects of early intervention among patients with bipolar disorder aged 18-25 years to that of patients aged 26 years or older.METHODS: Patients were randomised to early treatment in a specialised outpatient mood disorder clinic versus standard care. The primary outcome was risk of psychiatric re-hospitalisation.RESULTS: A total of 158 patients with mania/bipolar disorder were included among whom 29 (18.4%) were between 18 and 25 years and 129 patients were 26 years or older. For both age groups, the point estimate of the hazard ratio of re-hospitalisation was insignificantly decreased for patients treated in the mood disorder clinic versus standard treatment but more so for patients between 18 and 25 years (HR 0.33, 95% CI 0.10-1.07; p=0.064) than for patients 26 years or older (HR 0.68, 95% CI 0.40-1.14, p=0.14). Younger adults treated in the mood disorder clinic used mood stabilisers and antipsychotics more in contrast to those treated in standard care. The differences between the estimates of effects did not reach significance in tests of interactions (p>0.2).LIMITATIONS: The study was based on a post hoc subgroup analysis and due to the small number of patients aged 18-25 years, type II errors cannot be excluded.CONCLUSIONS: Although not statistically different, the observed differences of the point estimates was surprisingly larger for young adults suggesting that young adults with bipolar disorder may benefit even more than older adults from early intervention combining pharmacological treatment and group psychoeducation.

AB - BACKGROUND: It is unknown whether young adults with bipolar disorder are able to benefit from early intervention combining optimised pharmacological treatment and group psychoeducation. The aim of the present report was to compare the effects of early intervention among patients with bipolar disorder aged 18-25 years to that of patients aged 26 years or older.METHODS: Patients were randomised to early treatment in a specialised outpatient mood disorder clinic versus standard care. The primary outcome was risk of psychiatric re-hospitalisation.RESULTS: A total of 158 patients with mania/bipolar disorder were included among whom 29 (18.4%) were between 18 and 25 years and 129 patients were 26 years or older. For both age groups, the point estimate of the hazard ratio of re-hospitalisation was insignificantly decreased for patients treated in the mood disorder clinic versus standard treatment but more so for patients between 18 and 25 years (HR 0.33, 95% CI 0.10-1.07; p=0.064) than for patients 26 years or older (HR 0.68, 95% CI 0.40-1.14, p=0.14). Younger adults treated in the mood disorder clinic used mood stabilisers and antipsychotics more in contrast to those treated in standard care. The differences between the estimates of effects did not reach significance in tests of interactions (p>0.2).LIMITATIONS: The study was based on a post hoc subgroup analysis and due to the small number of patients aged 18-25 years, type II errors cannot be excluded.CONCLUSIONS: Although not statistically different, the observed differences of the point estimates was surprisingly larger for young adults suggesting that young adults with bipolar disorder may benefit even more than older adults from early intervention combining pharmacological treatment and group psychoeducation.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Antimanic Agents

KW - Antipsychotic Agents

KW - Bipolar Disorder

KW - Combined Modality Therapy

KW - Early Medical Intervention

KW - Female

KW - Hospitalization

KW - Humans

KW - Male

KW - Psychotherapy, Group

KW - Young Adult

U2 - 10.1016/j.jad.2013.10.001

DO - 10.1016/j.jad.2013.10.001

M3 - Journal article

C2 - 24268595

VL - 152-154

SP - 403

EP - 408

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -

ID: 138777937