Determinants of iron accumulation in deep grey matter of multiple sclerosis patients
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Determinants of iron accumulation in deep grey matter of multiple sclerosis patients. / Ropele, Stefan; Kilsdonk, Iris D; Wattjes, Mike P; Langkammer, Christian; de Graaf, Wolter L; Frederiksen, Jette L; Larsson, Henrik B; Yiannakas, Marios; Wheeler-Kingshott, Claudia Am; Enzinger, Christian; Khalil, Michael; Rocca, Maria A; Sprenger, Till; Amann, Michael; Kappos, Ludwig; Filippi, Massimo; Rovira, Alex; Ciccarelli, Olga; Barkhof, Frederik; Fazekas, Franz.
In: Multiple Sclerosis, Vol. 20, No. 13, 11.2014, p. 1692-1698.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Determinants of iron accumulation in deep grey matter of multiple sclerosis patients
AU - Ropele, Stefan
AU - Kilsdonk, Iris D
AU - Wattjes, Mike P
AU - Langkammer, Christian
AU - de Graaf, Wolter L
AU - Frederiksen, Jette L
AU - Larsson, Henrik B
AU - Yiannakas, Marios
AU - Wheeler-Kingshott, Claudia Am
AU - Enzinger, Christian
AU - Khalil, Michael
AU - Rocca, Maria A
AU - Sprenger, Till
AU - Amann, Michael
AU - Kappos, Ludwig
AU - Filippi, Massimo
AU - Rovira, Alex
AU - Ciccarelli, Olga
AU - Barkhof, Frederik
AU - Fazekas, Franz
N1 - © The Author(s), 2014.
PY - 2014/11
Y1 - 2014/11
N2 - BACKGROUND: Iron accumulation in deep grey matter (GM) structures is a consistent finding in multiple sclerosis (MS) patients. This study focused on the identification of independent determinants of iron accumulation using R2* mapping.SUBJECTS AND METHODS: Ninety-seven MS patients and 81 healthy controls were included in this multicentre study. R2* mapping was performed on 3T MRI systems. R2*in deep GM was corrected for age and was related to disease duration, disability, T2 lesion load and brain volume.RESULTS: Compared to controls, R2* was increased in all deep GM regions of MS patients except the globus pallidus and the substantia nigra. R2* increase was most pronounced in the progressive stage of the disease and independently predicted by disease duration and disability. Reduced cortical volume was not associated with iron accumulation in the deep GM with the exception of the substantia nigra and the red nucleus. In lesions, R2* was inversely correlated with disease duration and higher total lesion load.CONCLUSION: Iron accumulation in deep GM of MS patients is most strongly and independently associated with duration and severity of the disease. Additional associations between cortical GM atrophy and deep GM iron accumulation appear to exist in a region specific manner.
AB - BACKGROUND: Iron accumulation in deep grey matter (GM) structures is a consistent finding in multiple sclerosis (MS) patients. This study focused on the identification of independent determinants of iron accumulation using R2* mapping.SUBJECTS AND METHODS: Ninety-seven MS patients and 81 healthy controls were included in this multicentre study. R2* mapping was performed on 3T MRI systems. R2*in deep GM was corrected for age and was related to disease duration, disability, T2 lesion load and brain volume.RESULTS: Compared to controls, R2* was increased in all deep GM regions of MS patients except the globus pallidus and the substantia nigra. R2* increase was most pronounced in the progressive stage of the disease and independently predicted by disease duration and disability. Reduced cortical volume was not associated with iron accumulation in the deep GM with the exception of the substantia nigra and the red nucleus. In lesions, R2* was inversely correlated with disease duration and higher total lesion load.CONCLUSION: Iron accumulation in deep GM of MS patients is most strongly and independently associated with duration and severity of the disease. Additional associations between cortical GM atrophy and deep GM iron accumulation appear to exist in a region specific manner.
U2 - 10.1177/1352458514531085
DO - 10.1177/1352458514531085
M3 - Journal article
C2 - 24787429
VL - 20
SP - 1692
EP - 1698
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
SN - 1352-4585
IS - 13
ER -
ID: 138424378