CRP and suPAR are differently related to anthropometry and subclinical organ damage
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CRP and suPAR are differently related to anthropometry and subclinical organ damage. / Lyngbæk, Stig; Sehestedt, Thomas; Marott, Jacob L; Hansen, Tine W; Olsen, Michael H; Andersen, Ove; Linneberg, Allan; Madsbad, Sten; Haugaard, Steen B; Eugen-Olsen, Jesper; Jeppesen, Jørgen.
In: International Journal of Cardiology, Vol. 167, No. 3, 08.2013, p. 781-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - CRP and suPAR are differently related to anthropometry and subclinical organ damage
AU - Lyngbæk, Stig
AU - Sehestedt, Thomas
AU - Marott, Jacob L
AU - Hansen, Tine W
AU - Olsen, Michael H
AU - Andersen, Ove
AU - Linneberg, Allan
AU - Madsbad, Sten
AU - Haugaard, Steen B
AU - Eugen-Olsen, Jesper
AU - Jeppesen, Jørgen
N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
PY - 2013/8
Y1 - 2013/8
N2 - BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects of the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI) (P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CONCLUSIONS: CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis.
AB - BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects of the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI) (P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CONCLUSIONS: CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis.
U2 - 10.1016/j.ijcard.2012.03.040
DO - 10.1016/j.ijcard.2012.03.040
M3 - Journal article
C2 - 22459389
VL - 167
SP - 781
EP - 785
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 3
ER -
ID: 40140020