Collagenous sprue: a coeliac disease look-alike with different treatment strategy
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Collagenous sprue : a coeliac disease look-alike with different treatment strategy. / Soendergaard, Christoffer; Riis, Lene Buhl; Nielsen, Ole Haagen.
In: BMJ Case Reports, Vol. 2014, 2014.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Collagenous sprue
T2 - a coeliac disease look-alike with different treatment strategy
AU - Soendergaard, Christoffer
AU - Riis, Lene Buhl
AU - Nielsen, Ole Haagen
PY - 2014
Y1 - 2014
N2 - Collagenous sprue is a rare clinicopathological condition of the small bowel. It is characterised by abnormal subepithelial collagen deposition and is typically associated with malabsorption, diarrhoea and weight loss. The clinical features of collagenous sprue often resemble those of coeliac disease and together with frequent histological findings like mucosal thinning and intraepithelial lymphocytosis the diagnosis may be hard to reach without awareness of this condition. While coeliac disease is treated using gluten restriction, collagenous sprue is, however, not improved by this intervention. In cases of diet-refractory 'coeliac disease' it is therefore essential to consider collagenous sprue to initiate treatment at an early stage to prevent the fibrotic progression. Here, we report a case of a 78-year-old man with collagenous sprue and present the clinical and histological manifestations as well as the successful treatment course that he underwent.
AB - Collagenous sprue is a rare clinicopathological condition of the small bowel. It is characterised by abnormal subepithelial collagen deposition and is typically associated with malabsorption, diarrhoea and weight loss. The clinical features of collagenous sprue often resemble those of coeliac disease and together with frequent histological findings like mucosal thinning and intraepithelial lymphocytosis the diagnosis may be hard to reach without awareness of this condition. While coeliac disease is treated using gluten restriction, collagenous sprue is, however, not improved by this intervention. In cases of diet-refractory 'coeliac disease' it is therefore essential to consider collagenous sprue to initiate treatment at an early stage to prevent the fibrotic progression. Here, we report a case of a 78-year-old man with collagenous sprue and present the clinical and histological manifestations as well as the successful treatment course that he underwent.
KW - Aged
KW - Budesonide
KW - Calcium
KW - Celiac Disease
KW - Collagenous Sprue
KW - Diagnosis, Differential
KW - Dietary Supplements
KW - Glucocorticoids
KW - Humans
KW - Male
KW - Vitamin D
KW - Vitamins
U2 - 10.1136/bcr-2014-203721
DO - 10.1136/bcr-2014-203721
M3 - Journal article
C2 - 24682141
VL - 2014
JO - BMJ Case Reports
JF - BMJ Case Reports
SN - 1757-790X
ER -
ID: 138619004