Chest-CT protocol standardization for multicentre trial in cystic fibrosis (CF) infants
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Standard
Chest-CT protocol standardization for multicentre trial in cystic fibrosis (CF) infants. / Ciet, P.; Graniel, K. Gonzalez; Stick, S.; de Bruijne, Marleen; Tiddens, H.; Straten, M. van.
In: Insights into Imaging, Vol. 4, No. Supplement 1, B-0737, 2013.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - ABST
T1 - Chest-CT protocol standardization for multicentre trial in cystic fibrosis (CF) infants
AU - Ciet, P.
AU - Graniel, K. Gonzalez
AU - Stick, S.
AU - de Bruijne, Marleen
AU - Tiddens, H.
AU - Straten, M. van
PY - 2013
Y1 - 2013
N2 - Purpose: To standardise the scan protocol for CT scanners of participating centres in a multi-centre study (clinicaltrials.gov NCT01270074) for the prevention of radiologically defined bronchiectasis in CF infants by ensuring the maximum image quality at the minimum radiation dose. Methods and Materials: Three different sized phantoms (QRM, Germany) were used to assess scanners’ performance of automatic exposure control (AEC). CTDI and DLP were recorded. The phantoms contained various inserts to assess slice-sensitivity-profile, in-plane spatial resolution, noise and the Hounsfield Unit (HU) scale. Scans were made for several dose levels and reconstruction kernels. Images were analysed with custom-made software (MatLab, USA) to obtain the standard deviation of the noise, point-spread-function (PSF) and slice thickness. Results: Eight different scanners with 64 slices or more from 4 manufacturers (GE, Philips, Siemens and Toshiba) were assessed. Despite differences in AEC’s performance, we obtained approximately the same dose level at each center by recommending site and age-specific AEC reference levels. A constant image quality was only possible by matching the different reconstruction kernels measured PSFs at full-width-at-half-maximum. In fact, large part of the differences between scanners was related to reconstruction kernels. The relatively high noise images corresponded with reconstructions using a kernel with edge enhancement such as the Siemens B70 kernel or the GE lung kernel that are routinely used in chest imaging. Conclusion: Objective measurements on CT images allowed for matching of scan protocols among CT scanners of different manufacturers. Use of routine protocols might introduce a bias in the (automated) image analysis.
AB - Purpose: To standardise the scan protocol for CT scanners of participating centres in a multi-centre study (clinicaltrials.gov NCT01270074) for the prevention of radiologically defined bronchiectasis in CF infants by ensuring the maximum image quality at the minimum radiation dose. Methods and Materials: Three different sized phantoms (QRM, Germany) were used to assess scanners’ performance of automatic exposure control (AEC). CTDI and DLP were recorded. The phantoms contained various inserts to assess slice-sensitivity-profile, in-plane spatial resolution, noise and the Hounsfield Unit (HU) scale. Scans were made for several dose levels and reconstruction kernels. Images were analysed with custom-made software (MatLab, USA) to obtain the standard deviation of the noise, point-spread-function (PSF) and slice thickness. Results: Eight different scanners with 64 slices or more from 4 manufacturers (GE, Philips, Siemens and Toshiba) were assessed. Despite differences in AEC’s performance, we obtained approximately the same dose level at each center by recommending site and age-specific AEC reference levels. A constant image quality was only possible by matching the different reconstruction kernels measured PSFs at full-width-at-half-maximum. In fact, large part of the differences between scanners was related to reconstruction kernels. The relatively high noise images corresponded with reconstructions using a kernel with edge enhancement such as the Siemens B70 kernel or the GE lung kernel that are routinely used in chest imaging. Conclusion: Objective measurements on CT images allowed for matching of scan protocols among CT scanners of different manufacturers. Use of routine protocols might introduce a bias in the (automated) image analysis.
U2 - 10.1007/s13244-013-0228-x
DO - 10.1007/s13244-013-0228-x
M3 - Conference abstract in journal
VL - 4
JO - Insights into Imaging
JF - Insights into Imaging
SN - 1869-4101
IS - Supplement 1
M1 - B-0737
Y2 - 7 March 2013 through 11 March 2013
ER -
ID: 169283845