Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis

Research output: Contribution to journal › Journal article › Research

Standard

Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis. / Sørensen, Torben Lykke; Roed, Hanne; Sellebjerg, Finn.

In: Journal of Neuroimmunology, Vol. 122, No. 1-2, 01.2002, p. 125-31.

Research output: Contribution to journal › Journal article › Research

Harvard

Sørensen, TL, Roed, H & Sellebjerg, F 2002, 'Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis', Journal of Neuroimmunology, vol. 122, no. 1-2, pp. 125-31.

APA

Sørensen, T. L., Roed, H., & Sellebjerg, F. (2002). Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis. Journal of Neuroimmunology, 122(1-2), 125-31.

Vancouver

Sørensen TL, Roed H, Sellebjerg F. Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis. Journal of Neuroimmunology. 2002 Jan;122(1-2):125-31.

Author

Sørensen, Torben Lykke ; Roed, Hanne ; Sellebjerg, Finn. / Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis. In: Journal of Neuroimmunology. 2002 ; Vol. 122, No. 1-2. pp. 125-31.

Bibtex

@article{60abebc0f540418e89c471ab68fe6cf0,
title = "Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis",
abstract = "We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.",
keywords = "Adjuvants, Immunologic, Adult, B-Lymphocytes, Cerebrospinal Fluid, Demyelinating Diseases, Female, Flow Cytometry, Humans, Interferon-beta, Male, Middle Aged, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting, Receptors, CCR5, Receptors, CXCR3, Receptors, CXCR5, Receptors, Chemokine, Receptors, Cytokine",
author = "S{\o}rensen, {Torben Lykke} and Hanne Roed and Finn Sellebjerg",
year = "2002",
month = jan,
language = "English",
volume = "122",
pages = "125--31",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis

AU - Sørensen, Torben Lykke

AU - Roed, Hanne

AU - Sellebjerg, Finn

PY - 2002/1

Y1 - 2002/1

N2 - We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.

AB - We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.

KW - Adjuvants, Immunologic

KW - Adult

KW - B-Lymphocytes

KW - Cerebrospinal Fluid

KW - Demyelinating Diseases

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Interferon-beta

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis, Chronic Progressive

KW - Multiple Sclerosis, Relapsing-Remitting

KW - Receptors, CCR5

KW - Receptors, CXCR3

KW - Receptors, CXCR5

KW - Receptors, Chemokine

KW - Receptors, Cytokine

M3 - Journal article

C2 - 11777551

VL - 122

SP - 125

EP - 131

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -

ID: 111410738