Change in proportional protein intake in a 10-week energy-restricted low- or high-fat diet, in relation to changes in body size and metabolic factors
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Change in proportional protein intake in a 10-week energy-restricted low- or high-fat diet, in relation to changes in body size and metabolic factors. / Stocks, Tanja; Taylor, Moira A; Ängquist, Lars; Macdonald, Ian A; Arner, Peter; Holst, Claus; Oppert, Jean-Michel; Martinez, J Alfredo; Rössner, Stephan; Polak, Jan; Langin, Dominique; Saris, Wim H M; Astrup, Arne; Sørensen, Thorkild I.A.
In: Obesity Facts, Vol. 6, No. 3, 2013, p. 217-227.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Change in proportional protein intake in a 10-week energy-restricted low- or high-fat diet, in relation to changes in body size and metabolic factors
AU - Stocks, Tanja
AU - Taylor, Moira A
AU - Ängquist, Lars
AU - Macdonald, Ian A
AU - Arner, Peter
AU - Holst, Claus
AU - Oppert, Jean-Michel
AU - Martinez, J Alfredo
AU - Rössner, Stephan
AU - Polak, Jan
AU - Langin, Dominique
AU - Saris, Wim H M
AU - Astrup, Arne
AU - Sørensen, Thorkild I.A.
N1 - CURIS 2013 NEXS 120
PY - 2013
Y1 - 2013
N2 - Objective: To investigate in a secondary analysis of a randomised trial the effects of a low-/high-fat diet and reported change from baseline in energy% from protein (prot%), in relation to changes in body size and metabolic factors. Methods: Obese adults (n = 771) were randomised to a 600 kcal energy-deficient low-fat (20-25 fat%) or high-fat (40-45 fat%) diet over 10 weeks. Dietary intake data at baseline and during the intervention were available in 585 completers. We used linear regression to calculate the combined effects of randomised group and groups of prot% change (2) on outcomes. Results: The low-fat group with >2 prot% increase lost 1.1 kg more weight (p = 0.03) and reduced cholesterol by 0.25 mmol/l more (p = 0.003) than the high-fat group with >2 prot% decrease. These differences were 2.5-fold and 1.8-fold greater than the differences between the low-fat and high-fat groups while not considering prot% change. The high-fat group reduced plasma triglycerides more than the low-fat group, but not compared to those in the low-fat group with >2 units prot% increase (p fat-protein interaction = 0.01). Conclusions: Under energy restriction, participants on a low-fat diet who had increased the percentage energy intake from protein showed the greatest reduction in weight and cholesterol, and a triglyceride reduction equally large to that of participants on a high-fat diet. Copyright © 2013 S. Karger GmbH, Freiburg.
AB - Objective: To investigate in a secondary analysis of a randomised trial the effects of a low-/high-fat diet and reported change from baseline in energy% from protein (prot%), in relation to changes in body size and metabolic factors. Methods: Obese adults (n = 771) were randomised to a 600 kcal energy-deficient low-fat (20-25 fat%) or high-fat (40-45 fat%) diet over 10 weeks. Dietary intake data at baseline and during the intervention were available in 585 completers. We used linear regression to calculate the combined effects of randomised group and groups of prot% change (2) on outcomes. Results: The low-fat group with >2 prot% increase lost 1.1 kg more weight (p = 0.03) and reduced cholesterol by 0.25 mmol/l more (p = 0.003) than the high-fat group with >2 prot% decrease. These differences were 2.5-fold and 1.8-fold greater than the differences between the low-fat and high-fat groups while not considering prot% change. The high-fat group reduced plasma triglycerides more than the low-fat group, but not compared to those in the low-fat group with >2 units prot% increase (p fat-protein interaction = 0.01). Conclusions: Under energy restriction, participants on a low-fat diet who had increased the percentage energy intake from protein showed the greatest reduction in weight and cholesterol, and a triglyceride reduction equally large to that of participants on a high-fat diet. Copyright © 2013 S. Karger GmbH, Freiburg.
U2 - 10.1159/000351726
DO - 10.1159/000351726
M3 - Journal article
C2 - 23711745
VL - 6
SP - 217
EP - 227
JO - Obesity Facts
JF - Obesity Facts
SN - 1662-4025
IS - 3
ER -
ID: 45845980