TY - JOUR

T1 - BCG protects against tuberculosis irrespective of HIV status

T2 - a matched case-control study in Mwanza, Tanzania

AU - Faurholt-Jepsen, Daniel

AU - Range, Nyagosya

AU - PrayGod, George

AU - Jeremiah, Kidola

AU - Faurholt-Jepsen, Maria

AU - Aabye, Martine G

AU - Grewal, Harleen M S

AU - Changalucha, John

AU - Witte, Daniel R

AU - Andersen, Aase B

AU - Friis, Henrik

N1 - CURIS 2013 NEXS 044

PY - 2013

Y1 - 2013

N2 - While BCG vaccine protects against severe tuberculosis (TB) in children, its effect against adult TB is questionable. Furthermore, it is not known if HIV co-infection modifies the effect of BCG. Among 352 pairs of Tanzanian TB cases and matched controls, the BCG scar was associated with a reduced risk of TB (OR 0.3, 95% CI 0.2 to 0.7, p=0.005), irrespective of HIV status (interaction, p=0.623). BCG vaccination considerably reduced the risk of TB, both among individuals with and without HIV infection.

AB - While BCG vaccine protects against severe tuberculosis (TB) in children, its effect against adult TB is questionable. Furthermore, it is not known if HIV co-infection modifies the effect of BCG. Among 352 pairs of Tanzanian TB cases and matched controls, the BCG scar was associated with a reduced risk of TB (OR 0.3, 95% CI 0.2 to 0.7, p=0.005), irrespective of HIV status (interaction, p=0.623). BCG vaccination considerably reduced the risk of TB, both among individuals with and without HIV infection.

U2 - 10.1136/thoraxjnl-2012-201971

DO - 10.1136/thoraxjnl-2012-201971

M3 - Letter

C2 - 22923459

VL - 68

SP - 288

EP - 289

JO - Thorax

JF - Thorax

SN - 0040-6376

IS - 3

ER -