Asthma affects time to pregnancy and fertility: a register-based twin study
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Asthma affects time to pregnancy and fertility : a register-based twin study. / Gade, Elisabeth J; Thomsen, Simon F; Lindenberg, Svend; Kyvik, Kirsten O; Lieberoth, Sofie; Backer, Vibeke.
In: European Respiratory Journal, Vol. 43, No. 4, 04.2014, p. 1077-1085.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Asthma affects time to pregnancy and fertility
T2 - a register-based twin study
AU - Gade, Elisabeth J
AU - Thomsen, Simon F
AU - Lindenberg, Svend
AU - Kyvik, Kirsten O
AU - Lieberoth, Sofie
AU - Backer, Vibeke
PY - 2014/4
Y1 - 2014/4
N2 - Coexistence of infertility and asthma has been observed clinically. Therefore, we investigated the association between asthma and delayed pregnancy in a nationwide population-based cohort of twins. A cohort of 15 250 twins living in Denmark (aged 12-41 years) participated in a questionnaire study including questions about the presence of asthma and fertility. Differences in time to pregnancy and pregnancy outcome were analysed in subjects with asthma, allergy and in healthy individuals using multiple regression analysis. Asthma was associated with an increased time to pregnancy, the percentage of asthmatics with a time to pregnancy >1 year was 27% versus 21.6% for non-asthmatics (OR (95% CI) 1.31 (1.1-1.6); p=0.009). The association remained significant after adjustment for age, age at menarche, body mass index and socioeconomic status (OR (95% CI) 1.25 (1.0-1.6); p=0.05), and was more pronounced in those >30 years of age (32.2% versus 24.9%, OR (95% CI) 1.44 (1.1-1.9); p=0.04). Untreated asthmatics had a significant increased risk of prolonged time to pregnancy compared to healthy individuals (OR (95% CI) 1.79 (1.20-2.66); p=0.004), while asthmatics receiving any kind of treatment for asthma tended to have a shorter time to pregnancy than untreated asthmatics (OR 1.40; p=0.134). Asthma prolongs time to pregnancy. The negative effect of asthma on fertility increases with age and with disease intensity, indicating that a systemic disease characterised by systemic inflammation also can involve reproductive processes.
AB - Coexistence of infertility and asthma has been observed clinically. Therefore, we investigated the association between asthma and delayed pregnancy in a nationwide population-based cohort of twins. A cohort of 15 250 twins living in Denmark (aged 12-41 years) participated in a questionnaire study including questions about the presence of asthma and fertility. Differences in time to pregnancy and pregnancy outcome were analysed in subjects with asthma, allergy and in healthy individuals using multiple regression analysis. Asthma was associated with an increased time to pregnancy, the percentage of asthmatics with a time to pregnancy >1 year was 27% versus 21.6% for non-asthmatics (OR (95% CI) 1.31 (1.1-1.6); p=0.009). The association remained significant after adjustment for age, age at menarche, body mass index and socioeconomic status (OR (95% CI) 1.25 (1.0-1.6); p=0.05), and was more pronounced in those >30 years of age (32.2% versus 24.9%, OR (95% CI) 1.44 (1.1-1.9); p=0.04). Untreated asthmatics had a significant increased risk of prolonged time to pregnancy compared to healthy individuals (OR (95% CI) 1.79 (1.20-2.66); p=0.004), while asthmatics receiving any kind of treatment for asthma tended to have a shorter time to pregnancy than untreated asthmatics (OR 1.40; p=0.134). Asthma prolongs time to pregnancy. The negative effect of asthma on fertility increases with age and with disease intensity, indicating that a systemic disease characterised by systemic inflammation also can involve reproductive processes.
KW - Adolescent
KW - Adult
KW - Asthma
KW - Body Mass Index
KW - Child
KW - Denmark
KW - Female
KW - Fertility
KW - Humans
KW - Infertility
KW - Odds Ratio
KW - Pregnancy
KW - Pregnancy Complications
KW - Pregnancy Outcome
KW - Questionnaires
KW - Regression Analysis
KW - Social Class
KW - Time-to-Pregnancy
KW - Young Adult
U2 - 10.1183/09031936.00148713
DO - 10.1183/09031936.00148713
M3 - Journal article
C2 - 24232708
VL - 43
SP - 1077
EP - 1085
JO - The European Respiratory Journal
JF - The European Respiratory Journal
SN - 0903-1936
IS - 4
ER -
ID: 138770236