Association between a genetic variant in the serotonin transporter gene (SLC6A4) and suicidal behavior in patients with schizophrenia
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Association between a genetic variant in the serotonin transporter gene (SLC6A4) and suicidal behavior in patients with schizophrenia. / Lindholm Carlstrom, Eva; Saetre, Peter; Rosengren, Anders; Thygesen, Johan H; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole A; Werge, Thomas; Agartz, Ingrid; Hall, Håkan; Terenius, Lars; Jönsson, Erik G.
In: Behavioral and Brain Functions, Vol. 8, No. 1, 05.2012.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Association between a genetic variant in the serotonin transporter gene (SLC6A4) and suicidal behavior in patients with schizophrenia
AU - Lindholm Carlstrom, Eva
AU - Saetre, Peter
AU - Rosengren, Anders
AU - Thygesen, Johan H
AU - Djurovic, Srdjan
AU - Melle, Ingrid
AU - Andreassen, Ole A
AU - Werge, Thomas
AU - Agartz, Ingrid
AU - Hall, Håkan
AU - Terenius, Lars
AU - Jönsson, Erik G
PY - 2012/5
Y1 - 2012/5
N2 - ABSTRACT: BACKGROUND: The serotonin (5-hydroxytryptamin; 5-HT) system has a central role in the circuitry of cognition and emotions. Multiple lines of evidence suggest that genetic variation in the serotonin transporter gene (SLC6A4; 5-HTT) is associated with schizophrenia and suicidal behavior. In this study, we wanted to elucidate whether SLC6A4 variations is involved in attempted suicide among patients with schizophrenia in a Scandinavian case-control sample. METHODS: Patients diagnosed with schizophrenia from three Scandinavian samples were assessed for presence or absence of suicide attempts, based on record reviews and interview data. Seven SLC6A4 single nucleotide polymorphisms (SNPs) were genotyped in 837 schizophrenia patients and 1,473 control individuals. Association analyses and statistical evaluations were performed with the program UNPHASED (version 3.0.9). RESULTS: We observed an allele association between the SNP rs16965628, located in intron one of SLC6A4, and attempted suicide (adjusted P-value = 0.04), among patients with schizophrenia. No association was found to a diagnosis of schizophrenia, when patients were compared to healthy control individuals. CONCLUSION: The gene SLC6A4 appears to be involved in suicidal ideation among patients with schizophrenia. Independent replication is needed before more firm conclusions can be drawn.
AB - ABSTRACT: BACKGROUND: The serotonin (5-hydroxytryptamin; 5-HT) system has a central role in the circuitry of cognition and emotions. Multiple lines of evidence suggest that genetic variation in the serotonin transporter gene (SLC6A4; 5-HTT) is associated with schizophrenia and suicidal behavior. In this study, we wanted to elucidate whether SLC6A4 variations is involved in attempted suicide among patients with schizophrenia in a Scandinavian case-control sample. METHODS: Patients diagnosed with schizophrenia from three Scandinavian samples were assessed for presence or absence of suicide attempts, based on record reviews and interview data. Seven SLC6A4 single nucleotide polymorphisms (SNPs) were genotyped in 837 schizophrenia patients and 1,473 control individuals. Association analyses and statistical evaluations were performed with the program UNPHASED (version 3.0.9). RESULTS: We observed an allele association between the SNP rs16965628, located in intron one of SLC6A4, and attempted suicide (adjusted P-value = 0.04), among patients with schizophrenia. No association was found to a diagnosis of schizophrenia, when patients were compared to healthy control individuals. CONCLUSION: The gene SLC6A4 appears to be involved in suicidal ideation among patients with schizophrenia. Independent replication is needed before more firm conclusions can be drawn.
U2 - 10.1186/1744-9081-8-24
DO - 10.1186/1744-9081-8-24
M3 - Journal article
C2 - 22594806
VL - 8
JO - Behavioral and Brain Functions
JF - Behavioral and Brain Functions
SN - 1744-9081
IS - 1
ER -
ID: 48611292