Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample

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Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample. / Tesli, Martin; Athanasiu, Lavinia; Mattingsdal, Morten; Kähler, Anna K; Gustafsson, Omar; Andreassen, Bettina K; Werge, Thomas; Hansen, Thomas; Mors, Ole; Mellerup, Erling; Koefoed, Pernille; Jönsson, Erik G; Agartz, Ingrid; Melle, Ingrid; Morken, Gunnar; Djurovic, Srdjan; Andreassen, Ole A.

In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Vol. 153B, No. 7, 10.2010, p. 1276-82.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tesli, M, Athanasiu, L, Mattingsdal, M, Kähler, AK, Gustafsson, O, Andreassen, BK, Werge, T, Hansen, T, Mors, O, Mellerup, E, Koefoed, P, Jönsson, EG, Agartz, I, Melle, I, Morken, G, Djurovic, S & Andreassen, OA 2010, 'Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 153B, no. 7, pp. 1276-82. https://doi.org/10.1002/ajmg.b.31098

APA

Tesli, M., Athanasiu, L., Mattingsdal, M., Kähler, A. K., Gustafsson, O., Andreassen, B. K., Werge, T., Hansen, T., Mors, O., Mellerup, E., Koefoed, P., Jönsson, E. G., Agartz, I., Melle, I., Morken, G., Djurovic, S., & Andreassen, O. A. (2010). Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 153B(7), 1276-82. https://doi.org/10.1002/ajmg.b.31098

Vancouver

Tesli M, Athanasiu L, Mattingsdal M, Kähler AK, Gustafsson O, Andreassen BK et al. Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 2010 Oct;153B(7):1276-82. https://doi.org/10.1002/ajmg.b.31098

Author

Tesli, Martin ; Athanasiu, Lavinia ; Mattingsdal, Morten ; Kähler, Anna K ; Gustafsson, Omar ; Andreassen, Bettina K ; Werge, Thomas ; Hansen, Thomas ; Mors, Ole ; Mellerup, Erling ; Koefoed, Pernille ; Jönsson, Erik G ; Agartz, Ingrid ; Melle, Ingrid ; Morken, Gunnar ; Djurovic, Srdjan ; Andreassen, Ole A. / Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample. In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 2010 ; Vol. 153B, No. 7. pp. 1276-82.

Bibtex

@article{b272d217c44541aa802adc04cd5afd32,
title = "Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample",
abstract = "A recent genome-wide association study (GWAS) found significant association between the PALB2 SNP rs420259 and bipolar disorder (BD). The intracellular functions of the expressed proteins from the breast cancer risk genes PALB2 and BRCA2 are closely related. Therefore, we investigated the relation between genetic variants in PALB2 and BRCA2 and BD. Due to increasing evidence of genetic overlap between BD and schizophrenia (SCZ), we also investigated association with SCZ. In a Scandinavian case-control sample (n¿=¿686/2,538) we found the BRCA2 SNP rs9567552 to be significantly associated with BD (Nominal P¿=¿0.00043). Additionally, we replicated the association between PALB2 SNP rs420259 and BD (Nominal P¿=¿0.025). We then combined our sample with another Nordic case-control sample (n¿=¿435/11,491) from Iceland, and added results from the Wellcome Trust Case Control Consortium (WTCCC) (n¿=¿1,868/2,938) and the STEP-UCL/ED-DUB-STEP2 study (n¿=¿2,558/3,274) in a meta-analysis which revealed a P-value of 1.2¿×¿10(-5) for association between PALB2 SNP rs420259 and BD (n¿=¿5,547/20,241). Neither the PALB2 SNP rs420259 nor the BRCA2 SNP rs9567552 were nominally significantly associated with the SCZ phenotype in our Scandinavian sample (n¿=¿781/2,839). Our findings support PALB2 and BRCA2 as risk genes specifically for BD, and suggest that altered DNA repair related to neurogenesis may be involved in BD pathophysiology. {\textcopyright} 2010 Wiley-Liss, Inc.",
keywords = "BRCA2 Protein, Bipolar Disorder, Case-Control Studies, DNA Repair, Genetic Predisposition to Disease, Humans, Iceland, Neurogenesis, Nuclear Proteins, Polymorphism, Single Nucleotide, Scandinavia, Schizophrenia, Tumor Suppressor Proteins",
author = "Martin Tesli and Lavinia Athanasiu and Morten Mattingsdal and K{\"a}hler, {Anna K} and Omar Gustafsson and Andreassen, {Bettina K} and Thomas Werge and Thomas Hansen and Ole Mors and Erling Mellerup and Pernille Koefoed and J{\"o}nsson, {Erik G} and Ingrid Agartz and Ingrid Melle and Gunnar Morken and Srdjan Djurovic and Andreassen, {Ole A}",
year = "2010",
month = oct,
doi = "10.1002/ajmg.b.31098",
language = "English",
volume = "153B",
pages = "1276--82",
journal = "American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "JohnWiley & Sons, Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample

AU - Tesli, Martin

AU - Athanasiu, Lavinia

AU - Mattingsdal, Morten

AU - Kähler, Anna K

AU - Gustafsson, Omar

AU - Andreassen, Bettina K

AU - Werge, Thomas

AU - Hansen, Thomas

AU - Mors, Ole

AU - Mellerup, Erling

AU - Koefoed, Pernille

AU - Jönsson, Erik G

AU - Agartz, Ingrid

AU - Melle, Ingrid

AU - Morken, Gunnar

AU - Djurovic, Srdjan

AU - Andreassen, Ole A

PY - 2010/10

Y1 - 2010/10

N2 - A recent genome-wide association study (GWAS) found significant association between the PALB2 SNP rs420259 and bipolar disorder (BD). The intracellular functions of the expressed proteins from the breast cancer risk genes PALB2 and BRCA2 are closely related. Therefore, we investigated the relation between genetic variants in PALB2 and BRCA2 and BD. Due to increasing evidence of genetic overlap between BD and schizophrenia (SCZ), we also investigated association with SCZ. In a Scandinavian case-control sample (n¿=¿686/2,538) we found the BRCA2 SNP rs9567552 to be significantly associated with BD (Nominal P¿=¿0.00043). Additionally, we replicated the association between PALB2 SNP rs420259 and BD (Nominal P¿=¿0.025). We then combined our sample with another Nordic case-control sample (n¿=¿435/11,491) from Iceland, and added results from the Wellcome Trust Case Control Consortium (WTCCC) (n¿=¿1,868/2,938) and the STEP-UCL/ED-DUB-STEP2 study (n¿=¿2,558/3,274) in a meta-analysis which revealed a P-value of 1.2¿×¿10(-5) for association between PALB2 SNP rs420259 and BD (n¿=¿5,547/20,241). Neither the PALB2 SNP rs420259 nor the BRCA2 SNP rs9567552 were nominally significantly associated with the SCZ phenotype in our Scandinavian sample (n¿=¿781/2,839). Our findings support PALB2 and BRCA2 as risk genes specifically for BD, and suggest that altered DNA repair related to neurogenesis may be involved in BD pathophysiology. © 2010 Wiley-Liss, Inc.

AB - A recent genome-wide association study (GWAS) found significant association between the PALB2 SNP rs420259 and bipolar disorder (BD). The intracellular functions of the expressed proteins from the breast cancer risk genes PALB2 and BRCA2 are closely related. Therefore, we investigated the relation between genetic variants in PALB2 and BRCA2 and BD. Due to increasing evidence of genetic overlap between BD and schizophrenia (SCZ), we also investigated association with SCZ. In a Scandinavian case-control sample (n¿=¿686/2,538) we found the BRCA2 SNP rs9567552 to be significantly associated with BD (Nominal P¿=¿0.00043). Additionally, we replicated the association between PALB2 SNP rs420259 and BD (Nominal P¿=¿0.025). We then combined our sample with another Nordic case-control sample (n¿=¿435/11,491) from Iceland, and added results from the Wellcome Trust Case Control Consortium (WTCCC) (n¿=¿1,868/2,938) and the STEP-UCL/ED-DUB-STEP2 study (n¿=¿2,558/3,274) in a meta-analysis which revealed a P-value of 1.2¿×¿10(-5) for association between PALB2 SNP rs420259 and BD (n¿=¿5,547/20,241). Neither the PALB2 SNP rs420259 nor the BRCA2 SNP rs9567552 were nominally significantly associated with the SCZ phenotype in our Scandinavian sample (n¿=¿781/2,839). Our findings support PALB2 and BRCA2 as risk genes specifically for BD, and suggest that altered DNA repair related to neurogenesis may be involved in BD pathophysiology. © 2010 Wiley-Liss, Inc.

KW - BRCA2 Protein

KW - Bipolar Disorder

KW - Case-Control Studies

KW - DNA Repair

KW - Genetic Predisposition to Disease

KW - Humans

KW - Iceland

KW - Neurogenesis

KW - Nuclear Proteins

KW - Polymorphism, Single Nucleotide

KW - Scandinavia

KW - Schizophrenia

KW - Tumor Suppressor Proteins

U2 - 10.1002/ajmg.b.31098

DO - 10.1002/ajmg.b.31098

M3 - Journal article

C2 - 20872766

VL - 153B

SP - 1276

EP - 1282

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 7

ER -

ID: 32398153