An update of human mesenchymal stem cell biology and their clinical uses

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An update of human mesenchymal stem cell biology and their clinical uses. / Zaher, Walid; Harkness, Linda; Kermani, Abbas Jafari; Kassem, Moustapha.

In: Archives of Toxicology, Vol. 88, No. 5, 2014, p. 1069-82.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Zaher, W, Harkness, L, Kermani, AJ & Kassem, M 2014, 'An update of human mesenchymal stem cell biology and their clinical uses', Archives of Toxicology, vol. 88, no. 5, pp. 1069-82. https://doi.org/10.1007/s00204-014-1232-8

APA

Zaher, W., Harkness, L., Kermani, A. J., & Kassem, M. (2014). An update of human mesenchymal stem cell biology and their clinical uses. Archives of Toxicology, 88(5), 1069-82. https://doi.org/10.1007/s00204-014-1232-8

Vancouver

Zaher W, Harkness L, Kermani AJ, Kassem M. An update of human mesenchymal stem cell biology and their clinical uses. Archives of Toxicology. 2014;88(5):1069-82. https://doi.org/10.1007/s00204-014-1232-8

Author

Zaher, Walid ; Harkness, Linda ; Kermani, Abbas Jafari ; Kassem, Moustapha. / An update of human mesenchymal stem cell biology and their clinical uses. In: Archives of Toxicology. 2014 ; Vol. 88, No. 5. pp. 1069-82.

Bibtex

@article{8a0eb2fb11644a40b92f85937a31c4e1,
title = "An update of human mesenchymal stem cell biology and their clinical uses",
abstract = "In the past decade, an increasing urge to develop new and novel methods for the treatment of degenerative diseases where there is currently no effective therapy has lead to the emerging of the cell therapy or cellular therapeutics approach for the management of those conditions where organ functions are restored through transplantation of healthy and functional cells. Stem cells, because of their nature, are currently considered among the most suitable cell types for cell therapy. There are an increasing number of studies that have tested the stromal stem cell functionality both in vitro and in vivo. Consequently, stromal (mesenchymal) stem cells (MSCs) are being introduced into many clinical trials due to their ease of isolation and efficacy in treating a number of disease conditions in animal preclinical disease models. The aim of this review is to revise MSC biology, their potential translation in therapy, and the challenges facing their adaptation in clinical practice.",
keywords = "Adipocytes, Cell Differentiation, Chondrocytes, Graft vs Host Disease, Humans, Mesenchymal Stromal Cells, Osteoblasts, Pluripotent Stem Cells, Regeneration, Stem Cell Transplantation",
author = "Walid Zaher and Linda Harkness and Kermani, {Abbas Jafari} and Moustapha Kassem",
year = "2014",
doi = "10.1007/s00204-014-1232-8",
language = "English",
volume = "88",
pages = "1069--82",
journal = "Archives of Toxicology",
issn = "0340-5761",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - An update of human mesenchymal stem cell biology and their clinical uses

AU - Zaher, Walid

AU - Harkness, Linda

AU - Kermani, Abbas Jafari

AU - Kassem, Moustapha

PY - 2014

Y1 - 2014

N2 - In the past decade, an increasing urge to develop new and novel methods for the treatment of degenerative diseases where there is currently no effective therapy has lead to the emerging of the cell therapy or cellular therapeutics approach for the management of those conditions where organ functions are restored through transplantation of healthy and functional cells. Stem cells, because of their nature, are currently considered among the most suitable cell types for cell therapy. There are an increasing number of studies that have tested the stromal stem cell functionality both in vitro and in vivo. Consequently, stromal (mesenchymal) stem cells (MSCs) are being introduced into many clinical trials due to their ease of isolation and efficacy in treating a number of disease conditions in animal preclinical disease models. The aim of this review is to revise MSC biology, their potential translation in therapy, and the challenges facing their adaptation in clinical practice.

AB - In the past decade, an increasing urge to develop new and novel methods for the treatment of degenerative diseases where there is currently no effective therapy has lead to the emerging of the cell therapy or cellular therapeutics approach for the management of those conditions where organ functions are restored through transplantation of healthy and functional cells. Stem cells, because of their nature, are currently considered among the most suitable cell types for cell therapy. There are an increasing number of studies that have tested the stromal stem cell functionality both in vitro and in vivo. Consequently, stromal (mesenchymal) stem cells (MSCs) are being introduced into many clinical trials due to their ease of isolation and efficacy in treating a number of disease conditions in animal preclinical disease models. The aim of this review is to revise MSC biology, their potential translation in therapy, and the challenges facing their adaptation in clinical practice.

KW - Adipocytes

KW - Cell Differentiation

KW - Chondrocytes

KW - Graft vs Host Disease

KW - Humans

KW - Mesenchymal Stromal Cells

KW - Osteoblasts

KW - Pluripotent Stem Cells

KW - Regeneration

KW - Stem Cell Transplantation

U2 - 10.1007/s00204-014-1232-8

DO - 10.1007/s00204-014-1232-8

M3 - Review

C2 - 24691703

VL - 88

SP - 1069

EP - 1082

JO - Archives of Toxicology

JF - Archives of Toxicology

SN - 0340-5761

IS - 5

ER -

ID: 138175452