An introduction to proteoglycans and their localization

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An introduction to proteoglycans and their localization. / Couchman, John R; Pataki, Andreea Csilla.

In: Journal of Histochemistry and Cytochemistry, Vol. 60, No. 12, 12.2012, p. 885-97.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Couchman, JR & Pataki, AC 2012, 'An introduction to proteoglycans and their localization', Journal of Histochemistry and Cytochemistry, vol. 60, no. 12, pp. 885-97. https://doi.org/10.1369/0022155412464638

APA

Couchman, J. R., & Pataki, A. C. (2012). An introduction to proteoglycans and their localization. Journal of Histochemistry and Cytochemistry, 60(12), 885-97. https://doi.org/10.1369/0022155412464638

Vancouver

Couchman JR, Pataki AC. An introduction to proteoglycans and their localization. Journal of Histochemistry and Cytochemistry. 2012 Dec;60(12):885-97. https://doi.org/10.1369/0022155412464638

Author

Couchman, John R ; Pataki, Andreea Csilla. / An introduction to proteoglycans and their localization. In: Journal of Histochemistry and Cytochemistry. 2012 ; Vol. 60, No. 12. pp. 885-97.

Bibtex

@article{097591fb455647e8b8574bcbb6998ca6,
title = "An introduction to proteoglycans and their localization",
abstract = "Proteoglycans comprise a core protein to which one or more glycosaminoglycan chains are covalently attached. Although a small number of proteins have the capacity to be glycanated and become proteoglycans, it is now realized that these macromolecules have a range of functions, dependent on type and in vivo location, and have important roles in invertebrate and vertebrate development, maintenance, and tissue repair. Many biologically potent small proteins can bind glycosaminoglycan chains as a key part of their function in the extracellular matrix, at the cell surface, and also in some intracellular locations. Therefore, the participation of proteoglycans in disease is receiving increased attention. In this short review, proteoglycan structure, function, and localizations are summarized, with reference to accompanying reviews in this issue as well as other recent literature. Included are some remarks on proteoglycan and glycosaminoglycan localization techniques, with reference to the special physicochemical properties of these complex molecules.",
keywords = "Animals, Congenital Abnormalities, Diabetes Mellitus, Embryonic Development, Fibrosis, Glycosaminoglycans, Humans, Mutation, Neoplasms, Organ Specificity, Proteoglycans",
author = "Couchman, {John R} and Pataki, {Andreea Csilla}",
year = "2012",
month = dec,
doi = "10.1369/0022155412464638",
language = "English",
volume = "60",
pages = "885--97",
journal = "Journal of Histochemistry and Cytochemistry",
issn = "0022-1554",
publisher = "SAGE Publications",
number = "12",

}

RIS

TY - JOUR

T1 - An introduction to proteoglycans and their localization

AU - Couchman, John R

AU - Pataki, Andreea Csilla

PY - 2012/12

Y1 - 2012/12

N2 - Proteoglycans comprise a core protein to which one or more glycosaminoglycan chains are covalently attached. Although a small number of proteins have the capacity to be glycanated and become proteoglycans, it is now realized that these macromolecules have a range of functions, dependent on type and in vivo location, and have important roles in invertebrate and vertebrate development, maintenance, and tissue repair. Many biologically potent small proteins can bind glycosaminoglycan chains as a key part of their function in the extracellular matrix, at the cell surface, and also in some intracellular locations. Therefore, the participation of proteoglycans in disease is receiving increased attention. In this short review, proteoglycan structure, function, and localizations are summarized, with reference to accompanying reviews in this issue as well as other recent literature. Included are some remarks on proteoglycan and glycosaminoglycan localization techniques, with reference to the special physicochemical properties of these complex molecules.

AB - Proteoglycans comprise a core protein to which one or more glycosaminoglycan chains are covalently attached. Although a small number of proteins have the capacity to be glycanated and become proteoglycans, it is now realized that these macromolecules have a range of functions, dependent on type and in vivo location, and have important roles in invertebrate and vertebrate development, maintenance, and tissue repair. Many biologically potent small proteins can bind glycosaminoglycan chains as a key part of their function in the extracellular matrix, at the cell surface, and also in some intracellular locations. Therefore, the participation of proteoglycans in disease is receiving increased attention. In this short review, proteoglycan structure, function, and localizations are summarized, with reference to accompanying reviews in this issue as well as other recent literature. Included are some remarks on proteoglycan and glycosaminoglycan localization techniques, with reference to the special physicochemical properties of these complex molecules.

KW - Animals

KW - Congenital Abnormalities

KW - Diabetes Mellitus

KW - Embryonic Development

KW - Fibrosis

KW - Glycosaminoglycans

KW - Humans

KW - Mutation

KW - Neoplasms

KW - Organ Specificity

KW - Proteoglycans

U2 - 10.1369/0022155412464638

DO - 10.1369/0022155412464638

M3 - Journal article

C2 - 23019015

VL - 60

SP - 885

EP - 897

JO - Journal of Histochemistry and Cytochemistry

JF - Journal of Histochemistry and Cytochemistry

SN - 0022-1554

IS - 12

ER -

ID: 49106424