Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients. / Jespersen, Jakob G; Nedergaard, Anders; Reitelseder, Søren; Mikkelsen, Ulla R; Dideriksen, Kasper J; Agergaard, Jakob; Kreiner, Frederik; Pott, Frank C; Schjerling, Peter; Kjaer, Michael.

In: P L o S One, Vol. 6, No. 3, 2011, p. e18090.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jespersen, JG, Nedergaard, A, Reitelseder, S, Mikkelsen, UR, Dideriksen, KJ, Agergaard, J, Kreiner, F, Pott, FC, Schjerling, P & Kjaer, M 2011, 'Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients', P L o S One, vol. 6, no. 3, pp. e18090. https://doi.org/10.1371/journal.pone.0018090

APA

Jespersen, J. G., Nedergaard, A., Reitelseder, S., Mikkelsen, U. R., Dideriksen, K. J., Agergaard, J., Kreiner, F., Pott, F. C., Schjerling, P., & Kjaer, M. (2011). Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients. P L o S One, 6(3), e18090. https://doi.org/10.1371/journal.pone.0018090

Vancouver

Jespersen JG, Nedergaard A, Reitelseder S, Mikkelsen UR, Dideriksen KJ, Agergaard J et al. Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients. P L o S One. 2011;6(3):e18090. https://doi.org/10.1371/journal.pone.0018090

Author

Jespersen, Jakob G ; Nedergaard, Anders ; Reitelseder, Søren ; Mikkelsen, Ulla R ; Dideriksen, Kasper J ; Agergaard, Jakob ; Kreiner, Frederik ; Pott, Frank C ; Schjerling, Peter ; Kjaer, Michael. / Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients. In: P L o S One. 2011 ; Vol. 6, No. 3. pp. e18090.

Bibtex

@article{350e94a1d6754e74b790563373b09e6d,
title = "Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients",
abstract = "Skeletal muscle mass is controlled by myostatin and Akt-dependent signaling on mammalian target of rapamycin (mTOR), glycogen synthase kinase 3{\ss} (GSK3{\ss}) and forkhead box O (FoxO) pathways, but it is unknown how these pathways are regulated in critically ill human muscle. To describe factors involved in muscle mass regulation, we investigated the phosphorylation and expression of key factors in these protein synthesis and breakdown signaling pathways in thigh skeletal muscle of critically ill intensive care unit (ICU) patients compared with healthy controls.",
author = "Jespersen, {Jakob G} and Anders Nedergaard and S{\o}ren Reitelseder and Mikkelsen, {Ulla R} and Dideriksen, {Kasper J} and Jakob Agergaard and Frederik Kreiner and Pott, {Frank C} and Peter Schjerling and Michael Kjaer",
year = "2011",
doi = "http://dx.doi.org/10.1371/journal.pone.0018090",
language = "English",
volume = "6",
pages = "e18090",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients

AU - Jespersen, Jakob G

AU - Nedergaard, Anders

AU - Reitelseder, Søren

AU - Mikkelsen, Ulla R

AU - Dideriksen, Kasper J

AU - Agergaard, Jakob

AU - Kreiner, Frederik

AU - Pott, Frank C

AU - Schjerling, Peter

AU - Kjaer, Michael

PY - 2011

Y1 - 2011

N2 - Skeletal muscle mass is controlled by myostatin and Akt-dependent signaling on mammalian target of rapamycin (mTOR), glycogen synthase kinase 3ß (GSK3ß) and forkhead box O (FoxO) pathways, but it is unknown how these pathways are regulated in critically ill human muscle. To describe factors involved in muscle mass regulation, we investigated the phosphorylation and expression of key factors in these protein synthesis and breakdown signaling pathways in thigh skeletal muscle of critically ill intensive care unit (ICU) patients compared with healthy controls.

AB - Skeletal muscle mass is controlled by myostatin and Akt-dependent signaling on mammalian target of rapamycin (mTOR), glycogen synthase kinase 3ß (GSK3ß) and forkhead box O (FoxO) pathways, but it is unknown how these pathways are regulated in critically ill human muscle. To describe factors involved in muscle mass regulation, we investigated the phosphorylation and expression of key factors in these protein synthesis and breakdown signaling pathways in thigh skeletal muscle of critically ill intensive care unit (ICU) patients compared with healthy controls.

U2 - http://dx.doi.org/10.1371/journal.pone.0018090

DO - http://dx.doi.org/10.1371/journal.pone.0018090

M3 - Journal article

VL - 6

SP - e18090

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 3

ER -

ID: 40170843