A network meta-analysis on randomized trials focusing on the preventive effect of statins on contrast-induced nephropathy

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A network meta-analysis on randomized trials focusing on the preventive effect of statins on contrast-induced nephropathy. / Peruzzi, Mariangela; De Luca, Leonardo; Thomsen, Henrik S; Romagnoli, Enrico; D'Ascenzo, Fabrizio; Mancone, Massimo; Sardella, Gennaro; Lucisano, Luigi; Abbate, Antonio; Frati, Giacomo; Biondi-Zoccai, Giuseppe.

In: Journal of Biomedicine and Biotechnology, Vol. 2014, 2014, p. 1-10.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Peruzzi, M, De Luca, L, Thomsen, HS, Romagnoli, E, D'Ascenzo, F, Mancone, M, Sardella, G, Lucisano, L, Abbate, A, Frati, G & Biondi-Zoccai, G 2014, 'A network meta-analysis on randomized trials focusing on the preventive effect of statins on contrast-induced nephropathy', Journal of Biomedicine and Biotechnology, vol. 2014, pp. 1-10. https://doi.org/10.1155/2014/213239

APA

Peruzzi, M., De Luca, L., Thomsen, H. S., Romagnoli, E., D'Ascenzo, F., Mancone, M., Sardella, G., Lucisano, L., Abbate, A., Frati, G., & Biondi-Zoccai, G. (2014). A network meta-analysis on randomized trials focusing on the preventive effect of statins on contrast-induced nephropathy. Journal of Biomedicine and Biotechnology, 2014, 1-10. https://doi.org/10.1155/2014/213239

Vancouver

Peruzzi M, De Luca L, Thomsen HS, Romagnoli E, D'Ascenzo F, Mancone M et al. A network meta-analysis on randomized trials focusing on the preventive effect of statins on contrast-induced nephropathy. Journal of Biomedicine and Biotechnology. 2014;2014:1-10. https://doi.org/10.1155/2014/213239

Author

Peruzzi, Mariangela ; De Luca, Leonardo ; Thomsen, Henrik S ; Romagnoli, Enrico ; D'Ascenzo, Fabrizio ; Mancone, Massimo ; Sardella, Gennaro ; Lucisano, Luigi ; Abbate, Antonio ; Frati, Giacomo ; Biondi-Zoccai, Giuseppe. / A network meta-analysis on randomized trials focusing on the preventive effect of statins on contrast-induced nephropathy. In: Journal of Biomedicine and Biotechnology. 2014 ; Vol. 2014. pp. 1-10.

Bibtex

@article{b423dc87e05f4b39bc6b64d5ebdad781,
title = "A network meta-analysis on randomized trials focusing on the preventive effect of statins on contrast-induced nephropathy",
abstract = "Contrast-induced nephropathy is a common complication of iodinated contrast administration. Statins may reduce the risk of contrast-induced nephropathy, but data remain inconclusive. We summarized the evidence based on statins for the prevention of contrast-induced nephropathy with a network meta-analysis. Randomized trials focusing on statins were searched and pooled with random-effect odds ratios. A total of 14 trials (6,160 patients) were included, focusing on atorvastatin (high/low dose), rosuvastatin (high dose), simvastatin (high/low dose), and placebo or no statin therapy before contrast administration. The risk of contrast-induced nephropathy was reduced by atorvastatin high dose and rosuvastatin high dose, with no difference between these two agents. Results for atorvastatin low dose and simvastatin (high/low dose) in comparison to placebo were inconclusive. Atorvastatin and rosuvastatin administered at high doses and before iodinated contrast administration have a consistent and beneficial preventive effect on contrast-induced nephropathy and may actually halve its incidence.",
author = "Mariangela Peruzzi and {De Luca}, Leonardo and Thomsen, {Henrik S} and Enrico Romagnoli and Fabrizio D'Ascenzo and Massimo Mancone and Gennaro Sardella and Luigi Lucisano and Antonio Abbate and Giacomo Frati and Giuseppe Biondi-Zoccai",
year = "2014",
doi = "10.1155/2014/213239",
language = "English",
volume = "2014",
pages = "1--10",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - A network meta-analysis on randomized trials focusing on the preventive effect of statins on contrast-induced nephropathy

AU - Peruzzi, Mariangela

AU - De Luca, Leonardo

AU - Thomsen, Henrik S

AU - Romagnoli, Enrico

AU - D'Ascenzo, Fabrizio

AU - Mancone, Massimo

AU - Sardella, Gennaro

AU - Lucisano, Luigi

AU - Abbate, Antonio

AU - Frati, Giacomo

AU - Biondi-Zoccai, Giuseppe

PY - 2014

Y1 - 2014

N2 - Contrast-induced nephropathy is a common complication of iodinated contrast administration. Statins may reduce the risk of contrast-induced nephropathy, but data remain inconclusive. We summarized the evidence based on statins for the prevention of contrast-induced nephropathy with a network meta-analysis. Randomized trials focusing on statins were searched and pooled with random-effect odds ratios. A total of 14 trials (6,160 patients) were included, focusing on atorvastatin (high/low dose), rosuvastatin (high dose), simvastatin (high/low dose), and placebo or no statin therapy before contrast administration. The risk of contrast-induced nephropathy was reduced by atorvastatin high dose and rosuvastatin high dose, with no difference between these two agents. Results for atorvastatin low dose and simvastatin (high/low dose) in comparison to placebo were inconclusive. Atorvastatin and rosuvastatin administered at high doses and before iodinated contrast administration have a consistent and beneficial preventive effect on contrast-induced nephropathy and may actually halve its incidence.

AB - Contrast-induced nephropathy is a common complication of iodinated contrast administration. Statins may reduce the risk of contrast-induced nephropathy, but data remain inconclusive. We summarized the evidence based on statins for the prevention of contrast-induced nephropathy with a network meta-analysis. Randomized trials focusing on statins were searched and pooled with random-effect odds ratios. A total of 14 trials (6,160 patients) were included, focusing on atorvastatin (high/low dose), rosuvastatin (high dose), simvastatin (high/low dose), and placebo or no statin therapy before contrast administration. The risk of contrast-induced nephropathy was reduced by atorvastatin high dose and rosuvastatin high dose, with no difference between these two agents. Results for atorvastatin low dose and simvastatin (high/low dose) in comparison to placebo were inconclusive. Atorvastatin and rosuvastatin administered at high doses and before iodinated contrast administration have a consistent and beneficial preventive effect on contrast-induced nephropathy and may actually halve its incidence.

U2 - 10.1155/2014/213239

DO - 10.1155/2014/213239

M3 - Journal article

C2 - 25276771

VL - 2014

SP - 1

EP - 10

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

ER -

ID: 135227560