Reflux oesophagitis in heavy drinkers: Effect of ranitidine and alginate/metoclopramide

Research output: Contribution to journalJournal articleResearchpeer-review

Of 1, 400 consecutive patients applying to an outpatient clinic for treatment of alcoholism, 477 complained of upper abdominal dyspepsia. After 2 weeks of abstinence, 78 had persisting complaints; of these, 72% had oesophagitis at endoscopy. The 53 patients with oesophagitis as the sole diagnosis were randomized to treatment with either ranitidine or a combination of alginate/antacid chewing tablets and metoclopramide for 6 weeks in a double-blind, double-dummy design. Twenty-five patients left the study during the observation time due to relapse of alcoholism, and were only observed until then. No significant differences were found between the treatment groups concerning the course of symptoms and endoscopic or histological improvement.

Original languageEnglish
Issue number2
Pages (from-to)69-73
Number of pages5
Publication statusPublished - 1987
Externally publishedYes

    Research areas

  • Alcoholism, Alginate, Metoclopramide, Oesophagitis, Ranitidine

ID: 251991841