Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men

Research output: Contribution to journalJournal articleResearchpeer-review


  • Thea Emily Benson
  • Anne Gaml-Sorensen
  • Andreas Ernst
  • Nis Brix
  • Karin Sørig Hougaard
  • Katia Keglberg Haervig
  • Jens Peter Ellekilde Bonde
  • Tøttenborg, Sandra Søgaard
  • Christian H. Lindh
  • Cecilia Host Ramlau-Hansen
  • Gunnar Toft

Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross-sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18-20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile-divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre-pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.

Original languageEnglish
Article number1742
JournalInternational Journal of Environmental Research and Public Health
Issue number4
Number of pages12
Publication statusPublished - 2021

    Research areas

  • bisphenol, endocrine disruptor, epidemiology, male fertility, semen quality

Number of downloads are based on statistics from Google Scholar and www.ku.dk

No data available

ID: 258613612