Simulating haplotype blocks in the human genome
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Simulating haplotype blocks in the human genome. / Posada, David; Wiuf, Carsten.
In: Bioinformatics, Vol. 19, No. 2, 01.02.2003, p. 289-290.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Simulating haplotype blocks in the human genome
AU - Posada, David
AU - Wiuf, Carsten
PY - 2003/2/1
Y1 - 2003/2/1
N2 - A bioinformatic tool was written to simulate haplotypes and SNPs under a modified coalescent with recombination. The most important feature of this program is that it allows for the specification of non-homogeneous recombination rates, which results in the formation of the so-called 'haplotype blocks' of the human genome. The program also implements different mutation models and flexible demographic histories. The samples generated can be very useful to better understand the architecture of the human genome and to investigate its impact in association studies searching for disease genes.
AB - A bioinformatic tool was written to simulate haplotypes and SNPs under a modified coalescent with recombination. The most important feature of this program is that it allows for the specification of non-homogeneous recombination rates, which results in the formation of the so-called 'haplotype blocks' of the human genome. The program also implements different mutation models and flexible demographic histories. The samples generated can be very useful to better understand the architecture of the human genome and to investigate its impact in association studies searching for disease genes.
UR - http://www.scopus.com/inward/record.url?scp=0037314075&partnerID=8YFLogxK
U2 - 10.1093/bioinformatics/19.2.289
DO - 10.1093/bioinformatics/19.2.289
M3 - Journal article
C2 - 12538254
AN - SCOPUS:0037314075
VL - 19
SP - 289
EP - 290
JO - Bioinformatics (Online)
JF - Bioinformatics (Online)
SN - 1367-4811
IS - 2
ER -
ID: 203902757