Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals
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- Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals
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Serological response to treatment of syphilis with orally administered doxycycline or intramuscularly administered penicillin was assessed in patients with concurrent HIV. All HIV-infected individuals diagnosed with syphilis attending 3 hospitals in Copenhagen, Denmark were included. Odds ratios (ORs) with 95% confidence intervals (CI) associated with serological outcome were modelled using propensity-score-adjusted logistic regression analysis. In total, 202 cases were treated with doxycycline or intramuscular penicillin. At 12 months, serological failure was observed in 12 cases (15%) treated with doxycycline and in 8 cases (17%) treated with penicillin (OR 0.78 (95% CI 0.16-3.88), p = 0.76). The serological cure rate at 12 months was highest in patients with primary syphilis (100%), followed by patients with secondary (89%), early latent (71%) and late latent (67%) syphilis (p = 0.006). In conclusion, this study provides evidence for the use of doxycycline as a treatment option when treating a HIV-infected population for syphilis.
Original language | English |
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Journal | Acta Dermatovenereologica |
Volume | 96 |
Issue number | 6 |
Pages (from-to) | 807-811 |
Number of pages | 5 |
ISSN | 0001-5555 |
DOIs | |
Publication status | Published - 2016 |
- Administration, Oral, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Denmark, Doxycycline, Female, HIV Seropositivity, Humans, Injections, Male, Middle Aged, Penicillins, Retrospective Studies, Syphilis, Treatment Outcome, Comparative Study
Research areas
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