Major life events and risk of Parkinson's disease
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Major life events and risk of Parkinson's disease. / Rod, Naja Hulvej; Hansen, Johnni; Schernhammer, Eva; Ritz, Beate.
In: Movement Disorders, Vol. 25, No. 11, 15.08.2010, p. 1639-45.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Major life events and risk of Parkinson's disease
AU - Rod, Naja Hulvej
AU - Hansen, Johnni
AU - Schernhammer, Eva
AU - Ritz, Beate
PY - 2010/8/15
Y1 - 2010/8/15
N2 - Major life events such as divorce, death of a spouse or a child, or long-term unemployment are stressful to most people and animal models have suggested a link between stress and onset of parkinsonian symptoms. In a large case-control study based on nationwide registries, we aim to address whether major life events are risk factors for Parkinson's disease. Between 1986 and 2006, we identified 13,695 patients with a (PD) primary diagnosis of PD in the Danish National Hospital Register. Each case was frequency matched by age and gender to five population controls. Information on major life events before onset of PD was ascertained from national registries. Among men, number of life events was associated with risk of Parkinson's disease in an inverse dose-response manner (P <0.0001). Compared to no events, three or more events were associated with a 42% lower risk of PD (OR = 0.58; 95 % CI: 0.34-0.99). Life events were not associated with PD in women. In contrast, a higher risk of PD was observed among women who had never been married (1.16; 1.04-1.29) and among men (1.47; 1.18-1.82) and women (1.30; 1.05-1.61) who have never been employees. The lower risk of Parkinson's disease among men who had experienced life events was unexpected but might suggest a general "risk avoidance behavior" in Parkinson's patients.
AB - Major life events such as divorce, death of a spouse or a child, or long-term unemployment are stressful to most people and animal models have suggested a link between stress and onset of parkinsonian symptoms. In a large case-control study based on nationwide registries, we aim to address whether major life events are risk factors for Parkinson's disease. Between 1986 and 2006, we identified 13,695 patients with a (PD) primary diagnosis of PD in the Danish National Hospital Register. Each case was frequency matched by age and gender to five population controls. Information on major life events before onset of PD was ascertained from national registries. Among men, number of life events was associated with risk of Parkinson's disease in an inverse dose-response manner (P <0.0001). Compared to no events, three or more events were associated with a 42% lower risk of PD (OR = 0.58; 95 % CI: 0.34-0.99). Life events were not associated with PD in women. In contrast, a higher risk of PD was observed among women who had never been married (1.16; 1.04-1.29) and among men (1.47; 1.18-1.82) and women (1.30; 1.05-1.61) who have never been employees. The lower risk of Parkinson's disease among men who had experienced life events was unexpected but might suggest a general "risk avoidance behavior" in Parkinson's patients.
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and over
KW - Denmark
KW - Female
KW - Humans
KW - Life Change Events
KW - Male
KW - Middle Aged
KW - Parkinson Disease
KW - Retrospective Studies
KW - Risk Factors
KW - Sex Factors
U2 - 10.1002/mds.22850
DO - 10.1002/mds.22850
M3 - Journal article
C2 - 20602449
VL - 25
SP - 1639
EP - 1645
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 11
ER -
ID: 33264321