Integrating genomics into evolutionary medicine
Research output: Contribution to journal › Review › Research › peer-review
The application of the principles of evolutionary biology into medicine was suggested long ago and is already providing insight into the ultimate causes of disease. However, a full systematic integration of medical genomics and evolutionary medicine is still missing. Here, we briefly review some cases where the combination of the two fields has proven profitable and highlight two of the main issues hindering the development of evolutionary genomic medicine as a mature field, namely the dissociation between fitness and health and the still considerable difficulties in predicting phenotypes from genotypes. We use publicly available data to illustrate both problems and conclude that new approaches are needed for evolutionary genomic medicine to overcome these obstacles.
Original language | English |
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Journal | Current Opinion in Genetics and Development |
Volume | 29 |
Pages (from-to) | 97-102 |
Number of pages | 6 |
ISSN | 0959-437X |
DOIs | |
Publication status | Published - 2014 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:
© 2014.
ID: 332620550