HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development. / Gauvrit, Sebastien; Villasenor, Alethia; Strilic, Boris; Kitchen, Philip; Collins, Michelle M.; Marin-Juez, Ruben; Guenther, Stefan; Maischein, Hans-Martin; Fukuda, Nana; Canham, Maurice A.; Brickman, Joshua M.; Bogue, Clifford W.; Jayaraman, Padma-Sheela; Stainier, Didier Y. R.

In: Nature Communications, Vol. 9, No. 1, 2704, 2018.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gauvrit, S, Villasenor, A, Strilic, B, Kitchen, P, Collins, MM, Marin-Juez, R, Guenther, S, Maischein, H-M, Fukuda, N, Canham, MA, Brickman, JM, Bogue, CW, Jayaraman, P-S & Stainier, DYR 2018, 'HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.', Nature Communications, vol. 9, no. 1, 2704. https://doi.org/10.1038/s41467-018-05039-1

APA

Gauvrit, S., Villasenor, A., Strilic, B., Kitchen, P., Collins, M. M., Marin-Juez, R., Guenther, S., Maischein, H-M., Fukuda, N., Canham, M. A., Brickman, J. M., Bogue, C. W., Jayaraman, P-S., & Stainier, D. Y. R. (2018). HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development. Nature Communications, 9(1), [2704]. https://doi.org/10.1038/s41467-018-05039-1

Vancouver

Gauvrit S, Villasenor A, Strilic B, Kitchen P, Collins MM, Marin-Juez R et al. HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development. Nature Communications. 2018;9(1). 2704. https://doi.org/10.1038/s41467-018-05039-1

Author

Gauvrit, Sebastien ; Villasenor, Alethia ; Strilic, Boris ; Kitchen, Philip ; Collins, Michelle M. ; Marin-Juez, Ruben ; Guenther, Stefan ; Maischein, Hans-Martin ; Fukuda, Nana ; Canham, Maurice A. ; Brickman, Joshua M. ; Bogue, Clifford W. ; Jayaraman, Padma-Sheela ; Stainier, Didier Y. R. / HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development. In: Nature Communications. 2018 ; Vol. 9, No. 1.

Bibtex

@article{30caccab457349da911843ea49796e79,

title = "HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.",

abstract = "Formation of the lymphatic system requires the coordinated expression of several key regulators: vascular endothelial growth factor C (VEGFC), its receptor FLT4, and a key transcriptional effector, PROX1. Yet, how expression of these signaling components is regulated remains poorly understood. Here, using a combination of genetic and mol. approaches, we identify the transcription factor hematopoietically expressed homeobox (HHEX) as an upstream regulator of VEGFC, FLT4, and PROX1 during angiogenic sprouting and lymphatic formation in vertebrates. By analyzing zebrafish mutants, we found that hhex is necessary for sprouting angiogenesis from the posterior cardinal vein, a process required for lymphangiogenesis. Furthermore, studies of mammalian HHEX using tissue-specific genetic deletions in mouse and knockdowns in cultured human endothelial cells reveal its highly conserved function during vascular and lymphatic development. Our findings that HHEX is essential for the regulation of the VEGFC/FLT4/PROX1 axis provide insights into the mol. regulation of lymphangiogenesis. [on SciFinder(R)]",

author = "Sebastien Gauvrit and Alethia Villasenor and Boris Strilic and Philip Kitchen and Collins, {Michelle M.} and Ruben Marin-Juez and Stefan Guenther and Hans-Martin Maischein and Nana Fukuda and Canham, {Maurice A.} and Brickman, {Joshua M.} and Bogue, {Clifford W.} and Padma-Sheela Jayaraman and Stainier, {Didier Y. R.}",

year = "2018",

doi = "10.1038/s41467-018-05039-1",

language = "English",

volume = "9",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "nature publishing group",

number = "1",

}

RIS

TY - JOUR

T1 - HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.

AU - Gauvrit, Sebastien

AU - Villasenor, Alethia

AU - Strilic, Boris

AU - Kitchen, Philip

AU - Collins, Michelle M.

AU - Marin-Juez, Ruben

AU - Guenther, Stefan

AU - Maischein, Hans-Martin

AU - Fukuda, Nana

AU - Canham, Maurice A.

AU - Brickman, Joshua M.

AU - Bogue, Clifford W.

AU - Jayaraman, Padma-Sheela

AU - Stainier, Didier Y. R.

PY - 2018

Y1 - 2018

N2 - Formation of the lymphatic system requires the coordinated expression of several key regulators: vascular endothelial growth factor C (VEGFC), its receptor FLT4, and a key transcriptional effector, PROX1. Yet, how expression of these signaling components is regulated remains poorly understood. Here, using a combination of genetic and mol. approaches, we identify the transcription factor hematopoietically expressed homeobox (HHEX) as an upstream regulator of VEGFC, FLT4, and PROX1 during angiogenic sprouting and lymphatic formation in vertebrates. By analyzing zebrafish mutants, we found that hhex is necessary for sprouting angiogenesis from the posterior cardinal vein, a process required for lymphangiogenesis. Furthermore, studies of mammalian HHEX using tissue-specific genetic deletions in mouse and knockdowns in cultured human endothelial cells reveal its highly conserved function during vascular and lymphatic development. Our findings that HHEX is essential for the regulation of the VEGFC/FLT4/PROX1 axis provide insights into the mol. regulation of lymphangiogenesis. [on SciFinder(R)]

AB - Formation of the lymphatic system requires the coordinated expression of several key regulators: vascular endothelial growth factor C (VEGFC), its receptor FLT4, and a key transcriptional effector, PROX1. Yet, how expression of these signaling components is regulated remains poorly understood. Here, using a combination of genetic and mol. approaches, we identify the transcription factor hematopoietically expressed homeobox (HHEX) as an upstream regulator of VEGFC, FLT4, and PROX1 during angiogenic sprouting and lymphatic formation in vertebrates. By analyzing zebrafish mutants, we found that hhex is necessary for sprouting angiogenesis from the posterior cardinal vein, a process required for lymphangiogenesis. Furthermore, studies of mammalian HHEX using tissue-specific genetic deletions in mouse and knockdowns in cultured human endothelial cells reveal its highly conserved function during vascular and lymphatic development. Our findings that HHEX is essential for the regulation of the VEGFC/FLT4/PROX1 axis provide insights into the mol. regulation of lymphangiogenesis. [on SciFinder(R)]

U2 - 10.1038/s41467-018-05039-1

DO - 10.1038/s41467-018-05039-1

M3 - Journal article

C2 - 30006544

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 2704

ER -

ID: 202073481

Forskning