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Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. / Young, William J; Haessler, Jeffrey; Benjamins, Jan-Walter; Repetto, Linda; Yao, Jie; Isaacs, Aaron; Harper, Andrew R; Ramirez, Julia; Garnier, Sophie; van Duijvenboden, Stefan; Baldassari, Antoine R; Concas, Maria Pina; Duong, ThuyVy; Foco, Luisa; Isaksen, Jonas L; Mei, Hao; Noordam, Raymond; Nursyifa, Casia; Richmond, Anne; Santolalla, Meddly L; Sitlani, Colleen M; Soroush, Negin; Thériault, Sébastien; Trompet, Stella; Aeschbacher, Stefanie; Ahmadizar, Fariba; Alonso, Alvaro; Brody, Jennifer A; Campbell, Archie; Correa, Adolfo; Darbar, Dawood; De Luca, Antonio; Deleuze, Jean-François; Ellervik, Christina; Fuchsberger, Christian; Goel, Anuj; Grace, Christopher; Guo, Xiuqing; Hansen, Torben; Heckbert, Susan R; Jackson, Rebecca D.; Kors, Jan A; Lima-Costa, Maria Fernanda; Linneberg, Allan; Macfarlane, Peter W; Morrison, Alanna C; Navarro, Pau; Porteous, David J; Pramstaller, Peter P; Reiner, Alexander P; Risch, Lorenz; Schotten, Ulrich; Shen, Xia; Sinagra, Gianfranco; Soliman, Elsayed Z; Stoll, Monika; Tarazona-Santos, Eduardo; Tinker, Andrew; Trajanoska, Katerina; Villard, Eric; Warren, Helen R; Whitsel, Eric A; Wiggins, Kerri L; Arking, Dan E; Avery, Christy L; Conen, David; Girotto, Giorgia; Grarup, Niels; Hayward, Caroline; Jukema, J Wouter; Mook-Kanamori, Dennis O; Olesen, Morten Salling; Padmanabhan, Sandosh; Psaty, Bruce M; Pattaro, Cristian; Ribeiro, Antonio Luiz P; Rotter, Jerome I; Stricker, Bruno H; van der Harst, Pim; van Duijn, Cornelia M; Verweij, Niek; Wilson, James G; Orini, Michele; Charron, Philippe; Watkins, Hugh; Kooperberg, Charles; Lin, Henry J; Wilson, James F; Kanters, Jørgen K; Sotoodehnia, Nona; Mifsud, Borbala; Lambiase, Pier D; Tereshchenko, Larisa G; Munroe, Patricia B.
In:
Nature Communications, Vol. 14, No. 1, 1411, 14.03.2023.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Young, WJ, Haessler, J, Benjamins, J-W, Repetto, L, Yao, J, Isaacs, A, Harper, AR, Ramirez, J, Garnier, S, van Duijvenboden, S, Baldassari, AR, Concas, MP, Duong, T, Foco, L
, Isaksen, JL, Mei, H, Noordam, R
, Nursyifa, C, Richmond, A, Santolalla, ML, Sitlani, CM, Soroush, N, Thériault, S, Trompet, S, Aeschbacher, S, Ahmadizar, F, Alonso, A, Brody, JA, Campbell, A, Correa, A, Darbar, D, De Luca, A, Deleuze, J-F
, Ellervik, C, Fuchsberger, C, Goel, A, Grace, C, Guo, X
, Hansen, T, Heckbert, SR, Jackson, RD, Kors, JA, Lima-Costa, MF
, Linneberg, A, Macfarlane, PW, Morrison, AC, Navarro, P, Porteous, DJ, Pramstaller, PP, Reiner, AP, Risch, L, Schotten, U, Shen, X, Sinagra, G, Soliman, EZ, Stoll, M, Tarazona-Santos, E, Tinker, A, Trajanoska, K, Villard, E, Warren, HR, Whitsel, EA, Wiggins, KL, Arking, DE, Avery, CL, Conen, D, Girotto, G, Grarup, N, Hayward, C, Jukema, JW, Mook-Kanamori, DO
, Olesen, MS, Padmanabhan, S, Psaty, BM, Pattaro, C, Ribeiro, ALP, Rotter, JI, Stricker, BH, van der Harst, P, van Duijn, CM, Verweij, N, Wilson, JG, Orini, M, Charron, P, Watkins, H, Kooperberg, C, Lin, HJ, Wilson, JF
, Kanters, JK, Sotoodehnia, N, Mifsud, B, Lambiase, PD, Tereshchenko, LG & Munroe, PB 2023, '
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease',
Nature Communications, vol. 14, no. 1, 1411.
https://doi.org/10.1038/s41467-023-36997-w
APA
Young, W. J., Haessler, J., Benjamins, J-W., Repetto, L., Yao, J., Isaacs, A., Harper, A. R., Ramirez, J., Garnier, S., van Duijvenboden, S., Baldassari, A. R., Concas, M. P., Duong, T., Foco, L.
, Isaksen, J. L., Mei, H., Noordam, R.
, Nursyifa, C., Richmond, A., ... Munroe, P. B. (2023).
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease.
Nature Communications,
14(1), [1411].
https://doi.org/10.1038/s41467-023-36997-w
Vancouver
Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A et al.
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease.
Nature Communications. 2023 Mar 14;14(1). 1411.
https://doi.org/10.1038/s41467-023-36997-w
Author
Young, William J ; Haessler, Jeffrey ; Benjamins, Jan-Walter ; Repetto, Linda ; Yao, Jie ; Isaacs, Aaron ; Harper, Andrew R ; Ramirez, Julia ; Garnier, Sophie ; van Duijvenboden, Stefan ; Baldassari, Antoine R ; Concas, Maria Pina ; Duong, ThuyVy ; Foco, Luisa ; Isaksen, Jonas L ; Mei, Hao ; Noordam, Raymond ; Nursyifa, Casia ; Richmond, Anne ; Santolalla, Meddly L ; Sitlani, Colleen M ; Soroush, Negin ; Thériault, Sébastien ; Trompet, Stella ; Aeschbacher, Stefanie ; Ahmadizar, Fariba ; Alonso, Alvaro ; Brody, Jennifer A ; Campbell, Archie ; Correa, Adolfo ; Darbar, Dawood ; De Luca, Antonio ; Deleuze, Jean-François ; Ellervik, Christina ; Fuchsberger, Christian ; Goel, Anuj ; Grace, Christopher ; Guo, Xiuqing ; Hansen, Torben ; Heckbert, Susan R ; Jackson, Rebecca D. ; Kors, Jan A ; Lima-Costa, Maria Fernanda ; Linneberg, Allan ; Macfarlane, Peter W ; Morrison, Alanna C ; Navarro, Pau ; Porteous, David J ; Pramstaller, Peter P ; Reiner, Alexander P ; Risch, Lorenz ; Schotten, Ulrich ; Shen, Xia ; Sinagra, Gianfranco ; Soliman, Elsayed Z ; Stoll, Monika ; Tarazona-Santos, Eduardo ; Tinker, Andrew ; Trajanoska, Katerina ; Villard, Eric ; Warren, Helen R ; Whitsel, Eric A ; Wiggins, Kerri L ; Arking, Dan E ; Avery, Christy L ; Conen, David ; Girotto, Giorgia ; Grarup, Niels ; Hayward, Caroline ; Jukema, J Wouter ; Mook-Kanamori, Dennis O ; Olesen, Morten Salling ; Padmanabhan, Sandosh ; Psaty, Bruce M ; Pattaro, Cristian ; Ribeiro, Antonio Luiz P ; Rotter, Jerome I ; Stricker, Bruno H ; van der Harst, Pim ; van Duijn, Cornelia M ; Verweij, Niek ; Wilson, James G ; Orini, Michele ; Charron, Philippe ; Watkins, Hugh ; Kooperberg, Charles ; Lin, Henry J ; Wilson, James F ; Kanters, Jørgen K ; Sotoodehnia, Nona ; Mifsud, Borbala ; Lambiase, Pier D ; Tereshchenko, Larisa G ; Munroe, Patricia B. / Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. In: Nature Communications. 2023 ; Vol. 14, No. 1.
Bibtex
@article{94d9868c793b47e4aa30c1abd557b995,
title = "Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease",
abstract = "The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.",
keywords = "Humans, Cardiovascular Diseases/genetics, Atrioventricular Block, Genome-Wide Association Study, Risk Factors, Arrhythmias, Cardiac/genetics, Electrocardiography/methods, Biomarkers",
author = "Young, {William J} and Jeffrey Haessler and Jan-Walter Benjamins and Linda Repetto and Jie Yao and Aaron Isaacs and Harper, {Andrew R} and Julia Ramirez and Sophie Garnier and {van Duijvenboden}, Stefan and Baldassari, {Antoine R} and Concas, {Maria Pina} and ThuyVy Duong and Luisa Foco and Isaksen, {Jonas L} and Hao Mei and Raymond Noordam and Casia Nursyifa and Anne Richmond and Santolalla, {Meddly L} and Sitlani, {Colleen M} and Negin Soroush and S{\'e}bastien Th{\'e}riault and Stella Trompet and Stefanie Aeschbacher and Fariba Ahmadizar and Alvaro Alonso and Brody, {Jennifer A} and Archie Campbell and Adolfo Correa and Dawood Darbar and {De Luca}, Antonio and Jean-Fran{\c c}ois Deleuze and Christina Ellervik and Christian Fuchsberger and Anuj Goel and Christopher Grace and Xiuqing Guo and Torben Hansen and Heckbert, {Susan R} and Jackson, {Rebecca D.} and Kors, {Jan A} and Lima-Costa, {Maria Fernanda} and Allan Linneberg and Macfarlane, {Peter W} and Morrison, {Alanna C} and Pau Navarro and Porteous, {David J} and Pramstaller, {Peter P} and Reiner, {Alexander P} and Lorenz Risch and Ulrich Schotten and Xia Shen and Gianfranco Sinagra and Soliman, {Elsayed Z} and Monika Stoll and Eduardo Tarazona-Santos and Andrew Tinker and Katerina Trajanoska and Eric Villard and Warren, {Helen R} and Whitsel, {Eric A} and Wiggins, {Kerri L} and Arking, {Dan E} and Avery, {Christy L} and David Conen and Giorgia Girotto and Niels Grarup and Caroline Hayward and Jukema, {J Wouter} and Mook-Kanamori, {Dennis O} and Olesen, {Morten Salling} and Sandosh Padmanabhan and Psaty, {Bruce M} and Cristian Pattaro and Ribeiro, {Antonio Luiz P} and Rotter, {Jerome I} and Stricker, {Bruno H} and {van der Harst}, Pim and {van Duijn}, {Cornelia M} and Niek Verweij and Wilson, {James G} and Michele Orini and Philippe Charron and Hugh Watkins and Charles Kooperberg and Lin, {Henry J} and Wilson, {James F} and Kanters, {J{\o}rgen K} and Nona Sotoodehnia and Borbala Mifsud and Lambiase, {Pier D} and Tereshchenko, {Larisa G} and Munroe, {Patricia B}",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = mar,
day = "14",
doi = "10.1038/s41467-023-36997-w",
language = "English",
volume = "14",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",
}
RIS
TY - JOUR
T1 - Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
AU - Young, William J
AU - Haessler, Jeffrey
AU - Benjamins, Jan-Walter
AU - Repetto, Linda
AU - Yao, Jie
AU - Isaacs, Aaron
AU - Harper, Andrew R
AU - Ramirez, Julia
AU - Garnier, Sophie
AU - van Duijvenboden, Stefan
AU - Baldassari, Antoine R
AU - Concas, Maria Pina
AU - Duong, ThuyVy
AU - Foco, Luisa
AU - Isaksen, Jonas L
AU - Mei, Hao
AU - Noordam, Raymond
AU - Nursyifa, Casia
AU - Richmond, Anne
AU - Santolalla, Meddly L
AU - Sitlani, Colleen M
AU - Soroush, Negin
AU - Thériault, Sébastien
AU - Trompet, Stella
AU - Aeschbacher, Stefanie
AU - Ahmadizar, Fariba
AU - Alonso, Alvaro
AU - Brody, Jennifer A
AU - Campbell, Archie
AU - Correa, Adolfo
AU - Darbar, Dawood
AU - De Luca, Antonio
AU - Deleuze, Jean-François
AU - Ellervik, Christina
AU - Fuchsberger, Christian
AU - Goel, Anuj
AU - Grace, Christopher
AU - Guo, Xiuqing
AU - Hansen, Torben
AU - Heckbert, Susan R
AU - Jackson, Rebecca D.
AU - Kors, Jan A
AU - Lima-Costa, Maria Fernanda
AU - Linneberg, Allan
AU - Macfarlane, Peter W
AU - Morrison, Alanna C
AU - Navarro, Pau
AU - Porteous, David J
AU - Pramstaller, Peter P
AU - Reiner, Alexander P
AU - Risch, Lorenz
AU - Schotten, Ulrich
AU - Shen, Xia
AU - Sinagra, Gianfranco
AU - Soliman, Elsayed Z
AU - Stoll, Monika
AU - Tarazona-Santos, Eduardo
AU - Tinker, Andrew
AU - Trajanoska, Katerina
AU - Villard, Eric
AU - Warren, Helen R
AU - Whitsel, Eric A
AU - Wiggins, Kerri L
AU - Arking, Dan E
AU - Avery, Christy L
AU - Conen, David
AU - Girotto, Giorgia
AU - Grarup, Niels
AU - Hayward, Caroline
AU - Jukema, J Wouter
AU - Mook-Kanamori, Dennis O
AU - Olesen, Morten Salling
AU - Padmanabhan, Sandosh
AU - Psaty, Bruce M
AU - Pattaro, Cristian
AU - Ribeiro, Antonio Luiz P
AU - Rotter, Jerome I
AU - Stricker, Bruno H
AU - van der Harst, Pim
AU - van Duijn, Cornelia M
AU - Verweij, Niek
AU - Wilson, James G
AU - Orini, Michele
AU - Charron, Philippe
AU - Watkins, Hugh
AU - Kooperberg, Charles
AU - Lin, Henry J
AU - Wilson, James F
AU - Kanters, Jørgen K
AU - Sotoodehnia, Nona
AU - Mifsud, Borbala
AU - Lambiase, Pier D
AU - Tereshchenko, Larisa G
AU - Munroe, Patricia B
N1 - © 2023. The Author(s).
PY - 2023/3/14
Y1 - 2023/3/14
N2 - The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.
AB - The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.
KW - Humans
KW - Cardiovascular Diseases/genetics
KW - Atrioventricular Block
KW - Genome-Wide Association Study
KW - Risk Factors
KW - Arrhythmias, Cardiac/genetics
KW - Electrocardiography/methods
KW - Biomarkers
U2 - 10.1038/s41467-023-36997-w
DO - 10.1038/s41467-023-36997-w
M3 - Journal article
C2 - 36918541
VL - 14
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 1411
ER -