Effect of chemotherapy and aromatase inhibitors in the adjuvant treatment of breast cancer on glucose and insulin metabolism—A systematic review
Research output: Contribution to journal › Review › Research › peer-review
Documents
- Effect of chemotherapy and aromatase inhibitors in the adjuvant treatment of breast cancer on glucose and insulin metabolism—A systematic review
Final published version, 195 KB, PDF document
Introduction: Breast cancer (BC) is the most common cancer among women worldwide. With increasing survival rates, focus has expanded to long-term adverse effects of adjuvant chemotherapy and/or aromatase inhibitors. Weight gain during chemotherapy has been well documented, but the underlying mechanisms remain unclear. A change in glucose and insulin metabolism is a possible consequence. Methods: We searched PubMed on the 4th of May 2018, and found eight articles that compared measurements of glucose and insulin before and after chemotherapy and/or aromatase inhibitors in woman with BC. Results: A general trend of increased glucose and insulin is seen and likely to be caused by weight gain and/or changes in body composition as a consequence of adjuvant treatment of BC. Discussion: Due to methodological limitations including short follow-up times and small sample sizes, further studies are required to better describe metabolic consequences of adjuvant chemotherapy and/or aromatase inhibitors. Future studies could help identify patients in high-risk of developing cardiometabolic disease after BC treatment.
Original language | English |
---|---|
Journal | Cancer Medicine |
Volume | 8 |
Issue number | 1 |
Pages (from-to) | 238-245 |
Number of pages | 8 |
ISSN | 2045-7634 |
DOIs | |
Publication status | Published - 2019 |
- breast cancer, chemotherapy, glucose, insulin, weight gain
Research areas
Number of downloads are based on statistics from Google Scholar and www.ku.dk
ID: 230250328