Astrocytic pyruvate carboxylation: Status after 35 years
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Astrocytic pyruvate carboxylation : Status after 35 years. / Schousboe, Arne; Waagepetersen, Helle S.; Sonnewald, Ursula.
In: Journal of Neuroscience Research, Vol. 97, 01.01.2019, p. 890-896.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Astrocytic pyruvate carboxylation
T2 - Status after 35 years
AU - Schousboe, Arne
AU - Waagepetersen, Helle S.
AU - Sonnewald, Ursula
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The first two publications dealing with the question of the cellular localization of the enzyme pyruvate carboxylase (PC) which in the brain represents the most important metabolic pathway to allow anaplerosis of TCA cycle constituents were published in 1983 and 1985. Hence, 2018 marks the 35th anniversary of the notion based on the results of the publications provided above that PC-catalyzed anaplerosis in the brain is an astrocytic process. This review will provide the background for investigating this enzymatic pathway as well as a discussion of cataplerosis, the degradation of products from anaplerosis, and the current status of the functional significance of pyruvate carboxylation in brain metabolism.
AB - The first two publications dealing with the question of the cellular localization of the enzyme pyruvate carboxylase (PC) which in the brain represents the most important metabolic pathway to allow anaplerosis of TCA cycle constituents were published in 1983 and 1985. Hence, 2018 marks the 35th anniversary of the notion based on the results of the publications provided above that PC-catalyzed anaplerosis in the brain is an astrocytic process. This review will provide the background for investigating this enzymatic pathway as well as a discussion of cataplerosis, the degradation of products from anaplerosis, and the current status of the functional significance of pyruvate carboxylation in brain metabolism.
KW - anaplerosis
KW - astrocytes
KW - cataplerosis
KW - glutamate
KW - glutamine
KW - neurons
UR - http://www.scopus.com/inward/record.url?scp=85061987603&partnerID=8YFLogxK
U2 - 10.1002/jnr.24402
DO - 10.1002/jnr.24402
M3 - Review
C2 - 30801795
AN - SCOPUS:85061987603
VL - 97
SP - 890
EP - 896
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
SN - 0360-4012
ER -
ID: 222390875