Nina Mertz
Industrial postdoc
Pharmaceutical Physical and Analytical Chemistry
Universitetsparken 2
2100 København Ø
Teaching
I am teaching (lab exercises and classes) in the Pharmaceutical Physical Chemistry II course (Bachelor level) at Pharma School.
Current research
My current project involves a promising strategy for infection prophylaxis and improvement of post-operative pain control following joint replacement that is focused on local delivery of drugs such as antibiotics and NSAIDs at the surgical site. The drug delivery systems investigatied in this project are primarily in situ formed prodrug suspensions and liquid crystalline phases. Besides minimizing systemic toxicity and maximizing the local drug concentration in the surgical tissue, it is equally important to maintain therapeutic drug concentrations over prolonged periods of time. Therefore, injectable depot formulations enabling localized and sustained delivery of two or more loaded drugs are of high interest. Thus, to improve the outcomes of joint arthroplasties and facilitate patients’ rehabilitation and recovery, there is a need for such efficient drug delivery systems that are able to maintain and sustain therapeutic levels of antibiotics, local anesthetics, and anti-inflammatory agents at the surgical site.
Primary fields of research
My primary area of research concern parental depot formulations for intra-articular injection and the physicochemical characterization of such drug delivery systems. My work also involves the investigation of release mechanisms and kinetics from in situ formed controlled drug delivery systems.
ID: 165032513
Most downloads
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147
downloads
Basic characteristics and kinetics of degradation in aqueous buffer of selected diclofenac prodrugs intended for joint injection
Research output: Contribution to conference › Poster › Research › peer-review
Published -
54
downloads
Investigation of diclofenac release and dynamic structural behavior of non-lamellar liquid crystal formulations during in situ formation by UV–Vis imaging and SAXS
Research output: Contribution to journal › Journal article › Research › peer-review
Published