Kasper Harpsøe

• Presentation
• CV
• Research outputs
• Activities
• Keywords

I have worked within computational medicinal chemistry since I started my PhD in 2003 and have extensive experience with most molecular modeling techniques.

From 2014 to 2021, I was part of the Gloriam Group (gloriamgroup.org), which has G Protein-Coupled Receptors (GPCRs) as the main research focus. My role in the group was as project manager for our activities within computatoional drug design of small molecule and peptide ligands. Most of the work were in multidisciplinary drug discovery projects in close collaboration with medicinal chemists, molecular pharmacologist, structural biologists and data scientists from both academia and industry.

In my current position as manager of the Data and Computing Facility at the department, I manage our small GPU linux cluster and provide project support for the department research groups. 

Selected publications

1. Published

   GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors

   Huang, S., Xu, P., Shen, D., Simon, Icaro A, Mao, C., Tan, Y., Zhang, H., Harpsøe, Kasper, Li, H., Zhang, Y., You, C., Yu, X., Jiang, Y., Zhang, Y., Gloriam, David E. & Xu, H. E., 2022, In: Molecular Cell. 82, 14, p. 2681-2695.e6 15 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

2. Published

   Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139

   Zhou, Y., Daver, H., Trapkov, B., Wu, L., Wu, M., Harpsøe, Kasper, Gentry, P. R., Liu, K., Larionova, M., Liu, J., Chen, N., Bräuner, Hans, Gloriam, David E., Hua, T. & Liu, Z. J., 2022, In: Cell Research. 32, 2, p. 210-213

   Research output: Contribution to journal › Letter › Research › peer-review

3. Published

   Molecular Determinants underlying Delta Selective Compound 2 (DS2) Activity at δ-Containing GABAA Receptors

   Falk-Petersen, C. B., Rostrup, F., Löffler, R., Buchleihtner, S., Harpsøe, Kasper, Gloriam, David E., Frølund, Bente & Wellendorph, Petrine, 2021, In: Molecular Pharmacology. 100, 1, p. 46-56

   Research output: Contribution to journal › Journal article › Research › peer-review

4. Published

   Structural insights into the lipid and ligand regulation of serotonin receptors

   Xu, P., Huang, S., Zhang, H., Mao, C., Zhou, X. E., Cheng, X., Simon, Icaro A, Shen, D., Yen, H., Robinson, C. V., Harpsøe, Kasper, Svensson, B., Guo, J., Jiang, H., Gloriam, David E., Melcher, K., Jiang, Y., Zhang, Y. & Xu, H. E., 2021, In: Nature. 592, p. 469-473

   Research output: Contribution to journal › Journal article › Research › peer-review

5. Published

   Delineation of molecular determinants for FR900359 inhibition of G_q/11 unlocks inhibition of Gα_s

   Boesgaard, M. W., Harpsøe, Kasper, Malmberg, M., Underwood, C. R., Inoue, A., Mathiesen, Jesper M., König, G. M., Kostenis, E., Gloriam, David E. & Bräuner, Hans, 2020, In: Journal of Biological Chemistry. 295, 40, p. 13850-13861

   Research output: Contribution to journal › Journal article › Research › peer-review

6. Published

   5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

   Peng, Y., McCorvy, J. D., Harpsøe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajsen, L. F., Huang, X., Wu, Y., Shen, L., Bjørn-Yoshimoto, W. E., Ding, K., Wacker, D., Han, G. W., Cheng, J., Katritch, V., Jensen, A. A. & 6 others, Hanson, M. A., Zhao, S., Gloriam, David E., Roth, B. L., Stevens, R. C. & Liu, Z., 2018, In: Cell. 172, 4, p. 719-730 P719-730.E14.

   Research output: Contribution to journal › Journal article › Research › peer-review

7. Published

   Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

   Xiong, X., Zhang, H., Underwood, C. R., Harpsøe, Kasper, Gardella, T. J., Wöldike, M. F., Mannstadt, M., Gloriam, David E., Bräuner, Hans & Strømgaard, Kristian, 2016, In: Nature Chemistry. 8, 11, p. 1035-1041 7 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

8. Published

   Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

   Malfacini, D., Patt, J., Annala, S., Harpsøe, Kasper, Eryilmaz, F., Reher, R., Crüsemann, M., Hanke, W., Zhang, H., Tietze, D., Gloriam, David E., Bräuner, Hans, Strømgaard, Kristian, König, G. M., Inoue, A., Gomeza, J. & Kostenis, E., 12 Apr 2019, In: The Journal of Biological Chemistry. 294, 15, p. 5747-5758

   Research output: Contribution to journal › Journal article › Research › peer-review

9. Published

   Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors

   Harpsøe, Kasper, Ahring, P. K., Christensen, J. K., Jensen, M. L., Peters, D. & Balle, T., 27 Jul 2011, In: Journal of Neuroscience. 31, 30, p. 10759-10766

   Research output: Contribution to journal › Journal article › Research › peer-review