Christian Aalkjær

Christian Aalkjær

Emeritus


  1. 2023
  2. Published

    Acute, pro-contractile effects of prorenin on rat mesenteric arteries

    Rognant, Salomé, Baldwin, S. N., Pritchard, H. A. T., Greenstein, A., Callø, Kirstine, Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, 2023, In: FASEB Journal. 37, 12, 18 p., e23282.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Colchicine enhances β adrenoceptor-mediated vasodilation in men with essential hypertension

    Ehlers, T. S., van der Horst, Jennifer, Møller, S., Piil, P. K., Gliemann, Lasse, Aalkjær, Christian, Jepps, Thomas Andrew Qvistgaard & Hellsten, Ylva, 2023, In: British Journal of Clinical Pharmacology. 89, 7, p. 2179-2189 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    From pitfalls and pressures to culturing curiosity and creativity in early career physiologists

    Bailey, D. M., Fischer, Mads, Aalkjær, Christian & Secher, Niels H., 2023, In: The Physiological Society Magazine. 130, p. 11-11

    Research output: Contribution to journalComment/debate

  5. Published

    Professor Niels Henry Secher: Celebrating success from boat to bench to bedside

    Aalkjær, Christian, Fischer, Mads & Bailey, D. M., 2023, In: Experimental Physiology. 108, 10, p. 1233-1234

    Research output: Contribution to journalJournal article

  6. Published

    The cardiovascular challenges in giraffes

    Aalkjær, Christian & Wang, T., 2023, In: Journal of Muscle Research and Cell Motility. 44, p. 53–60 8 p.

    Research output: Contribution to journalReviewpeer-review

  7. 2022
  8. Published
  9. Published

    Identification of novel proteins and mechanistic pathways associated with early-onset hypertension by deep proteomic mapping of resistance arteries

    Bastrup, Joakim Armstrong, Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, 2022, In: Journal of Biological Chemistry. 298, 1, 17 p., 101512.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Migraine-Associated Mutation in the Na,K-ATPase Leads to Disturbances in Cardiac Metabolism and Reduced Cardiac Function

    Staehr, C., Rohde, P. D., Krarup, N. T., Ringgaard, S., Laustsen, C., Johnsen, J., Nielsen, R., Beck, H. C., Morth, J. P., Lykke-Hartmann, K., Jespersen, N. R., Abramochkin, D., Nyegaard, M., Botker, H. E., Aalkjær, Christian & Matchkov, V., 2022, In: Journal of the American Heart Association. 11, 7, 47 p., 021814.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    No guidelines for vascular nerves?

    De Mey, J. G. R., Simonsen, U. & Aalkjær, Christian, 2022, In: American Journal of Physiology - Heart and Circulatory Physiology. 322, 4, p. H681-H682

    Research output: Contribution to journalLetterpeer-review

  12. Published

    The microtubule network enables Src kinase interaction with the Na,K-ATPase to generate Ca2+ flashes in smooth muscle cells

    Rognant, Salomé, Kravtsova, V. V., Bouzinova, E. V., Melnikova, E. V., Krivoi, I. I., Pierre, S. V., Aalkjær, Christian, Jepps, Thomas Andrew Qvistgaard & Matchkov, V. V., 2022, In: Frontiers in Physiology. 13, 14 p., 1007340.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    The solution to bicarbonate

    Boedtkjer, E. & Aalkjær, Christian, 2022, In: American Journal of Physiology - Heart and Circulatory Physiology. 322, 4, p. H685-H686

    Research output: Contribution to journalLetterpeer-review

  14. 2021
  15. Published

    Brain capillary pericytes and neurovascular coupling

    Grubb, Søren, Lauritzen, Martin & Aalkjær, Christian, 2021, In: Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology. 254, 7 p., 110893.

    Research output: Contribution to journalReviewpeer-review

  16. Published

    Dynein regulates Kv7.4 channel trafficking from the cell membrane

    van der Horst, Jennifer, Rognant, Salomé, Abbott, G. W., Ozhathil, Lijo Cherian, Hägglund, Per Mårten, Barrese, V., Chuang, Christine, Jespersen, Thomas, Davies, Michael J., Greenwood, I. A., Gourdon, Pontus Emanuel, Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, 2021, In: Journal of General Physiology. 153, 3, 19 p., e202012760.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Mechanism and Consequence of Vasomotion

    Jacobsen, Jens Christian Brings & Aalkjær, Christian, 2021, Physics of Biological Oscillators: New Insights into Non-Equilibrium and Non-Autonomous Systems. Springer, p. 261-272 (Understanding Complex Systems).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  18. Published

    The Remarkable Cardiovascular System of Giraffes

    Aalkjær, Christian & Wang, T., 2021, In: Annual Review of Physiology. 83, p. 1-15

    Research output: Contribution to journalReviewpeer-review

  19. 2020
  20. Published

    Abnormal neurovascular coupling as a cause of excess cerebral vasodilaion in familial migarine

    Staehr, C., Rajanathan, R., Postnov, D. D., Hangaard, L., Bouzinova, E., Lykke-Hartmann, K., Bach, F. W., Sandow, S. L., Aalkjær, Christian & Matchkov, V. V., 2020, In: Cardiovascular Research. 116, 12, p. 2009-2020 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  21. 2019
  22. Published

    Perivascular Adipose Tissue Contributes to the Modulation of Vascular Tone in vivo

    Saxton, S. N., Withers, S. B., Nyvad, J., Mazur, A., Matchkov, V., Heagerty, A. M. & Aalkjær, Christian, 2019, In: Journal of Vascular Research. 56, 6, p. 320-332

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Rat mesenteric small artery neurogenic dilatation is predominantly mediated by beta(1)-adrenoceptors in vivo

    Sondergaard, A. M., Overgaard, C. B., Mazur, A., Postnov, D. D., Matchkov, V. V. & Aalkjær, Christian, 2019, In: The Journal of Physiology. 597, 7, p. 1819-1831

    Research output: Contribution to journalJournal articlepeer-review

  24. 2018
  25. Published

    4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances K7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries

    Khammy, M. M., Kim, S., Bentzen, Bo Hjorth, Lee, S., Choi, I., Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, Feb 2018, In: British Journal of Pharmacology. 175, 3, p. 501-516 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Microtubule Regulation of Kv7 Channels Orchestrates cAMP-Mediated Vasorelaxations in Rat Arterial Smooth Muscle

    Lindman, J., Khammy, M. M., Lundegaard, Pia Rengtved, Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, Feb 2018, In: Hypertension. 71, 2, p. 336-345 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. 2017
  28. Published

    Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome

    Thorsen, K., Dam, V. S., Kjaer-Sorensen, K., Pedersen, L. N., Skeberdis, V. A., Jurevicius, J., Treinys, R., Petersen, I. M. B. S., Nielsen, Morten Schak, Oxvig, C., Morth, J. P., Matchkov, V. V., Aalkjær, Christian, Bundgård, Henning & Jensen, H. K., 22 Nov 2017, In: Nature Communications. 8, 10 p., 1696.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Phosphodiesterase 1a inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries

    Khammy, M. M., Dalsgaard, T., Larsen, P. H., Christoffersen, C. T., Clausen, D., Rasmussen, L. K., Folkersen, L., Grunnet, Morten, Kehler, J., Aalkjær, Christian & Nielsen, J., Nov 2017, In: British Journal of Pharmacology. 174, 22, p. 4186-4198 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    Na-K-ATPase regulates intercellular communication in the vascular wall via CSRC Kinase-Dependent connexin43 phosphorylation

    Hangaard, L., Bouzinova, E. V., Staehr, C., Dam, V. S., Kim, S., Xie, Z., Aalkjær, Christian & Matchkov, V. V., Apr 2017, In: American Journal of Physiology - Cell Physiology. 312, 4, p. C385-C397

    Research output: Contribution to journalJournal articlepeer-review

  31. Spontaneous and Evoked Contractility of Human Intestinal Lymphatic Vessels

    Telinius, N., Majgaard, J., Mohanakumar, S., Pahle, E., Nielsen, J., Hjortdal, Vibeke Elisabeth, Aalkjær, Christian & Boedtkjer, D. B., Mar 2017, In: Lymphatic Research and Biology. 15, 1, p. 17-22 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    Increased NBCn1 expression, Na+/HCO- 3 co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension

    Ng, F. L., Boedtkjer, E., Witkowska, K., Ren, M., Zhang, R., Tucker, A., Aalkjær, Christian, Caulfield, M. J. & Ye, S., 2017, In: Human Molecular Genetics. 26, 5, p. 989-1002 14 p., ddx015.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    Intravital investigation of rat mesenteric small artery tone and blood flow

    Nyvad, J., Mazur, A., Postnov, D. D., Straarup, M. S., Soendergaard, A. M., Staehr, C., Brøndum, E., Aalkjær, Christian & Matchkov, V. V., 2017, In: Journal of Physiology. 595, 15, p. 5037-5053 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  34. 2016
  35. Published

    GLP-1 inhibits VEGFA-mediated signaling in isolated human endothelial cells and VEGFA-induced dilation of rat mesenteric arteries

    Rotbøl, C. E., Khammy, M. M., Dalsgaard, T., Mazur, A., Tritsaris, Katerina, Hansen, A. J., Aalkjær, Christian & Dissing, Steen, 1 Nov 2016, In: American Journal of Physiology: Heart and Circulatory Physiology. 311, 5, p. H1214-H1224

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    Negative News: Cl- and HCO3- in the Vascular Wall

    Bødtkjer, E., Matchkov, V. V., Boedtkjer, D. M. B. & Aalkjær, Christian, Sep 2016, In: Physiology. 31, 5, p. 370-383 14 p.

    Research output: Contribution to journalReviewpeer-review

  37. Published

    The thick left ventricular wall of the giraffe heart normalises wall tension, but limits stroke volume and cardiac output

    Smerup, M., Damkjær, M., Brøndum, E. T., Baandrup, U. T., Kristiansen, S. B., Nygaard, H., Funder, J. A., Aalkjær, Christian, Sauer, C., Buchanan, R., Bertelsen, Mads Frost, Østergaard, K. H., Grøndahl, C., Candy, G., Hasenkam, J. M., Secher, Niels H., Bie, P. & Wang, T., 2016, In: The Journal of Experimental Biology. 219, 3, p. 457-463 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  38. 2015
  39. Published

    Voltage-gated sodium channels contribute to action potentials and spontaneous contractility in isolated human lymphatic vessels

    Telinius, N., Majgaard, J., Kim, S., Katballe, N., Pahle, E., Nielsen, J., Hjortdal, Vibeke Elisabeth, Aalkjær, Christian & Boedtkjer, D. B., 15 Jul 2015, In: The Journal of Physiology. 593, 14, p. 3109-22 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  40. Published

    GLP-1 and its Analogue Liraglutide Affects Human Endothelial Cell Signaling by Reducing VEGF-A Induced Ca2+ Signaling and Activating Protein Kinases

    Rotbøl, C. E., Hansen, A., Tritsaris, Katerina, Xu, J., Aalkjær, Christian & Dissing, Steen, Apr 2015, In: F A S E B Journal. 29, 1 supplement, 1 p., 642.7.

    Research output: Contribution to journalConference abstract in journalpeer-review

  41. Published

    Role of peripheral vascular resistance for the association between major depression and cardiovascular disease

    Bouzinova, E. V., Wiborg, O., Aalkjær, Christian & Matchkov, V. V., Apr 2015, In: Journal of Cardiovascular Pharmacology. 65, 4, p. 299-307 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Extracellular Calcium-Dependent Modulation of Endothelium Relaxation in Rat Mesenteric Small Artery: The Role of Potassium Signaling

    Hangaard, L., Jessen, P. B., Kamaev, D., Aalkjær, Christian & Matchkov, V. V., 2015, In: BioMed Research International. 2015, p. 1-11 11 p., 758346.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    The giraffe kidney tolerates high arterial blood pressure by high renal interstitial pressure and low glomerular filtration rate

    Damkjær, M., Wang, T., Brøndum, E., Østergaard, K. H., Baandrup, U., Hørlyck, A., Hasenkam, J. M., Smerup, M., Funder, J., Marcussen, N., Danielsen, C. C., Bertelsen, Mads Frost, Grøndahl, C., Pedersen, M., Agger, P., Candy, G., Aalkjær, Christian & Bie, P., 2015, In: Acta Physiologica (Print). 214, 4, p. 497-510 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. 2014
  45. Published

    Human lymphatic vessel contractile activity is inhibited in vitro but not in vivo by the calcium channel blocker nifedipine

    Telinius, N., Mohanakumar, S., Majgaard, J., Kim, S., Pilegaard, H., Pahle, E., Nielsen, J., de Leval, M., Aalkjær, Christian, Hjortdal, Vibeke Elisabeth & Boedtkjer, D. B., 1 Nov 2014, In: The Journal of Physiology. 592, 21, p. 4697-714 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    The contribution of K(+) channels to human thoracic duct contractility

    Telinius, N., Kim, S., Pilegaard, H., Pahle, E., Nielsen, J., Hjortdal, Vibeke Elisabeth, Aalkjær, Christian & Boedtkjer, D. B., 1 Jul 2014, In: A J P: Heart and Circulatory Physiology (Online). 307, 1, p. H33-43

    Research output: Contribution to journalJournal articlepeer-review

  47. Published

    The human thoracic duct is functionally innervated by adrenergic nerves

    Telinius, N., Baandrup, U., Rumessen, J., Pilegaard, H., Hjortdal, Vibeke Elisabeth, Aalkjær, Christian & Boedtkjer, D. B., 15 Jan 2014, In: A J P: Heart and Circulatory Physiology (Online). 306, 2, p. H206-13

    Research output: Contribution to journalJournal articlepeer-review

  48. 2013
  49. Published

    Protection against high intravascular pressure in giraffe legs

    Petersen, K. K., Hørlyck, A., Østergaard, K. H., Andresen, J., Brøgger, T. H., Jensen, N. S., Telinius, N., Laher, I., Bertelsen, Mads Frost, Grøndahl, C., Smerup, M. H., Secher, Niels H., Brøndum, E. T., Hasenkam, J. M., Wang, T., Baandrup, U. & Aalkjær, Christian, 2013, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 305, 9, p. R1021-R1030 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  50. 2012
  51. NHE1 knockout reduces blood pressure and arterial media/lumen ratio with no effect on resting pH(i) in the vascular wall

    Boedtkjer, E., Damkier, H. H. & Aalkjær, Christian, 15 Apr 2012, In: The Journal of Physiology. 590, Pt 8, p. 1895-906 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  52. 2011
  53. Published

    Maternal smoking and impaired endothelium-dependent nitric oxide-mediated relaxation of uterine small arteries in vitro

    Andersen, M. R., Uldbjerg, N., Stender, Steen, Sandager, K. P. & Aalkjær, Christian, 2011, In: American Journal of Obstetrics and Gynecology. 204, 2, p. 177.e1–177.e7

    Research output: Contribution to journalJournal articlepeer-review

  54. 2010
  55. Published

    NBCn1 and NHE1 expression and activity in DeltaNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance

    Lauritzen, G., Jensen, M. B. F., Bødtkjer, E., Dybboe, R., Aalkjær, Christian, Nylandsted, J. & Pedersen, Stine Helene Falsig, 10 Sep 2010, In: Experimental Cell Research. 316, 15, p. 2538-53 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  56. Published

    Human thoracic duct in vitro: diameter-tension properties, spontaneous and evoked contractile activity

    Telinius, N., Drewsen, N., Pilegaard, H., Kold-Petersen, H., de Leval, M., Aalkjær, Christian, Hjortdal, Vibeke Elisabeth & Boedtkjer, D. B., Sep 2010, In: A J P: Heart and Circulatory Physiology (Online). 299, 3, p. H811-8

    Research output: Contribution to journalJournal articlepeer-review

  57. 2009
  58. Published

    Smoking cessation early in pregnancy and birth weight, length, head circumference, and endothelial nitric oxide synthase activity in umbilical and chorionic vessels: an observational study of healthy singleton pregnancies

    Andersen, M. R., Simonsen, U., Uldbjerg, N., Stender, Steen & Aalkjær, Christian, 2009, In: Circulation. 119, 6, p. 857-64 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  59. 2008
  60. Published

    Heterogeneity and weak coupling may explain the synchronization characteristics of cells in the arterial wall.

    Jacobsen, Jens Christian Brings, Aalkjær, Christian, Matchkov, V. V., Nilsson, H., von Holstein-Rathlou, Niels-Henrik & Freiberg, J. J., 2008, In: Philosophical Transactions. Series A : Mathematical, physical, and engineering science. 366, 1880, p. 3483-502 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  61. 2007
  62. Published

    Variable involvement of the perivascular retinal tissue in carbonic anhydrase inhibitor induced relaxation of porcine retinal arterioles in vitro.

    Kehler, A. K., Holmgaard, K., Hessellund, A., Aalkjær, Christian, Bek, T. & Toft-Kehler, A. K., 1 Oct 2007, In: Investigative Ophthalmology & Visual Science. 48, 10, p. 4688-4693 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  63. Published

    A model of smooth muscle cell synchronization in the arterial wall.

    Jacobsen, Jens Christian Brings, Aalkjær, Christian, Nilsson, H., Matchkov, V. V., Freiberg, J. & von Holstein-Rathlou, Niels-Henrik, 2007, In: American Journal of Physiology: Heart and Circulatory Physiology. 293, 1, p. H229-37

    Research output: Contribution to journalJournal articlepeer-review

  64. Published

    Activation of a cGMP-sensitive calcium-dependent chloride channel may cause transition from calcium waves to whole cell oscillations in smooth muscle cells.

    Jacobsen, Jens Christian Brings, Aalkjær, Christian, Nilsson, H., Matchkov, V. V., Freiberg, J. & von Holstein-Rathlou, Niels-Henrik, 2007, In: American Journal of Physiology: Heart and Circulatory Physiology. 293, 1, p. H215-28

    Research output: Contribution to journalJournal articlepeer-review

ID: 40980311