Solid-phase polyamine synthesis using piperazine and piperidine building blocks

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Christian A Olsen, Matthias Witt, Jerzy W Jaroszewski, Henrik Franzyk

[reaction: see text]. Polyamines containing piperidine and piperazine moieties have been synthesized on solid support using SN2 alkylation of resin-bound secondary amines with 2-nitrobenzenesulfonates (nosylates). The effect of solvent on this alkylation was investigated. The methodology was employed for the total synthesis of novel analogues of wasp polyamine toxins (philanthotoxins).
TidsskriftOrganic Letters
Udgave nummer22
Sider (fra-til)4183-5
Antal sider3
StatusUdgivet - 2003

ID: 42385442