Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians
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Originalsprog | Engelsk |
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Artikelnummer | 5064 |
Tidsskrift | Nature Communications |
Vol/bind | 15 |
Udgave nummer | 1 |
Antal sider | 10 |
ISSN | 2041-1723 |
DOI | |
Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:
This research was supported by: the European Union\u2019s Horizon 2020 Research and Innovation Programme: the \u201Cpredicting comorbid cardiovascular disease in individuals with mental disorder by decoding disease mechanisms\u201D project (CoMorMent, grant number 847776, to J.M., J.B., A.B., U.V., D.M., Y.L., T.W., O.A., and F.F.); the Danish National Research Foundation (grant number DNRF148); the US National Institutes of Health study on extreme MDD (R01 MH123724, to J.M., J.R.S., Y.L., and A.B.); the European Research Council (grant agreement ID 101042183, to Y.L.),.the Sir Henry Wellcome Postdoctoral Fellowship (Reference 213674/Z/18/Z, to D.H.); the Research Council of Norway (RCN grants 324499, 324252, 223273, to O.A.); the Stiftelsen Kristian Gerhard Jebsen (grants SKGJ-MED-008 and SKGJ-MED-021, to O.A).; the Laureate Grant Award from the Novo Nordisk Foundation (Grant No: NNF22OC0071010, to N.M.); European Research Council Consolidator grant (StressGene, Grant nr. 726413 to U.V.), and Icelandic Research fund (to U.V.). The iPSYCH Initiative is funded by the Lundbeck Foundation (Grant Nos. R268-2016-3925, R102-A9118, and R155-2014-1724), the Mental Health Services Capital Region of Denmark, University of Copenhagen, Aarhus University, and the University Hospital in Aarhus. Genotyping of iPSYCH samples was supported by grants from the Lundbeck Foundation, the Stanley Foundation, the Simons Foundation (Grant No. SFARI 311789), and the National Institutes of Mental Health (Grant No. 5U01MH094432-02). The iPSYCH Initiative uses the Danish National Biobank resource that is supported by the Novo Nordisk Foundation. We like to thank the Psychiatric Genomics Consortium working groups (major depressive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorder, schizophrenia, bipolar disorder, and eating disorders) for contributing genome-wide association summary statistics data. We like to thank all the senior members of the iPSYCH consortium: Preben Bo Mortensen, Anders B\u00F8rglum, David Hougaard, Thomas Werge, and Merete Nordentoft. Finally, we would like the thank Hakon Heimer for editing the final version of the manuscript and Mischa Lundberg for all-round moral support.
Publisher Copyright:
© The Author(s) 2024.
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