No sweet deal: the antibody-mediated immune response to malaria

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

IgG antibodies are key effector molecules in acquired immunity to Plasmodium falciparum malaria, and the PfEMP1 adhesins expressed on the surface of the infected erythrocytes are crucial immunological targets. The antigen specificity of these antibodies has therefore been a major research focus. However, we recently reported that the Fc domain of naturally induced PfEMP1-specific IgG1 is selectively modified by post-translational omission of fucose from the conserved Fc glycan. The resulting afucosylated IgG has increased affinity for the IgG-Fc-receptor III family (FcγRIII), found on natural killer cells and on subsets of other cells in the immune system. We discuss the implications of these findings for the basic understanding of antimalarial immunity and for the design of improved vaccines against the disease.

TidsskriftTrends in Parasitology
Udgave nummer6
Sider (fra-til)428-434
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
The work in the authors’ laboratories discussed in this article is supported by the Danish International Development Agency [grants 17-02-KU and BSU3-UG ] (L.H.), Danish Medical Research Council [grant 013400123B ] (M.L.P. and L.H.), and Landsteiner Foundation for Blood Transfusion Research (LSBR) [grant 1721 ] (G.V.).

Publisher Copyright:
© 2022 Elsevier Ltd

ID: 305715662