TY - JOUR

T1 - Near-infrared spectroscopy to measure brain oxygenation

T2 - A comparison of measurements on the skin, skull and dura mater

AU - Pedersen, Sofie S.

AU - Sørensen, Martin Kryspin

AU - Olsen, Markus Harboe

AU - Stisen, Zara R.

AU - Lund, Anton

AU - Møller, Kirsten

AU - Skjøth-Rasmussen, Jane

AU - Moltke, Finn B.

AU - Meyhoff, Christian S.

N1 - Publisher Copyright: © 2023 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.

PY - 2024

Y1 - 2024

N2 - Background: The reliability of near-infrared spectroscopy (NIRS) for measuring cerebral oxygenation (ScO2) is controversial due to the possible contamination from extracranial tissues. We compared ScO2 measured with the NIRS optode on the forehead, the skull and the dura mater in anaesthetised patients undergoing craniotomy. We hypothesised that ScO2 measured directly on the skull and the dura mater would differ from ScO2 measured on the skin. Methods: This prospective observational study included 17 adult patients scheduled for elective craniotomy. After induction of general anaesthesia, ScO2 was measured on the forehead skin, as well as on the skull and on the dura mater in the surgical field. The primary comparison was the difference in ScO2 measured on the dura mater and on ScO2 measured on the skin; secondary comparisons were the differences in ScO2 on the skull and ScO2 on the skin and the dura mater, respectively. Data were described with median (5%–95% range) and analysed with the Wilcoxon signed-rank test. Results: ScO2 values on the dura mater were obtained in 11 patients, and median ScO2 (48%, 29%–95%) did not differ significantly from ScO2 on the skin (73%, 49%–92%; p =.052), median difference −25% (−35.6% to −1.2%). ScO2 on the skull (N = 16) was lower than that on the skin (63% [43%–79%] vs. 75% [61%–94%]; p =.0002), median difference −10% (−20.8 to −3.0). Conclusion: In adults undergoing craniotomy, NIRS-based ScO2 measured on the dura mater did not reach statistically significantly lower values than ScO2 measured on the skin, whereas values on the skull were lower than on the skin, indicating a contribution from scalp tissue to the signal.

AB - Background: The reliability of near-infrared spectroscopy (NIRS) for measuring cerebral oxygenation (ScO2) is controversial due to the possible contamination from extracranial tissues. We compared ScO2 measured with the NIRS optode on the forehead, the skull and the dura mater in anaesthetised patients undergoing craniotomy. We hypothesised that ScO2 measured directly on the skull and the dura mater would differ from ScO2 measured on the skin. Methods: This prospective observational study included 17 adult patients scheduled for elective craniotomy. After induction of general anaesthesia, ScO2 was measured on the forehead skin, as well as on the skull and on the dura mater in the surgical field. The primary comparison was the difference in ScO2 measured on the dura mater and on ScO2 measured on the skin; secondary comparisons were the differences in ScO2 on the skull and ScO2 on the skin and the dura mater, respectively. Data were described with median (5%–95% range) and analysed with the Wilcoxon signed-rank test. Results: ScO2 values on the dura mater were obtained in 11 patients, and median ScO2 (48%, 29%–95%) did not differ significantly from ScO2 on the skin (73%, 49%–92%; p =.052), median difference −25% (−35.6% to −1.2%). ScO2 on the skull (N = 16) was lower than that on the skin (63% [43%–79%] vs. 75% [61%–94%]; p =.0002), median difference −10% (−20.8 to −3.0). Conclusion: In adults undergoing craniotomy, NIRS-based ScO2 measured on the dura mater did not reach statistically significantly lower values than ScO2 measured on the skin, whereas values on the skull were lower than on the skin, indicating a contribution from scalp tissue to the signal.

KW - cerebral oxygen saturation

KW - cerebral oxygenation

KW - near-infrared spectroscopy

U2 - 10.1111/aas.14344

DO - 10.1111/aas.14344

M3 - Journal article

C2 - 37877464

AN - SCOPUS:85174595494

VL - 68

SP - 188

EP - 194

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 2

ER -